Regulation of sigL Expression by the Catabolite Control Protein CcpA Involves a Roadblock Mechanism in Bacillus subtilis: Potential Connection between Carbon and Nitrogen Metabolism

ABSTRACT A catabolite-responsive element (CRE), a binding site for the CcpA transcription factor, was identified within the sigL structural gene encoding σL in Bacillus subtilis. We show that CcpA binds to this CRE to regulate sigL expression by a “roadblock” mechanism and that this mechanism in part accounts for catabolite repression of σL-directed levD operon expression.

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