The evolutionary origin of genetic instability in cancer development.

[1]  Marshall W. Anderson,et al.  Carcinogen-specific targeting of chromosome 12 for loss of heterozygosity in mouse lung adenocarcinomas: implications for chromosome instability and tumor progression , 2004, Oncogene.

[2]  G. Gaudernack,et al.  Resolving the evolutionary paradox of genetic instability: a cost–benefit analysis of DNA repair in changing environments , 2004, FEBS letters.

[3]  Yasuhiro Matsumura,et al.  Toxic effects of ultraviolet radiation on the skin. , 2004, Toxicology and applied pharmacology.

[4]  Tlj Kelly,et al.  Reproductive epigenetics , 2004, Clinical genetics.

[5]  Carlo Rago,et al.  Inactivation of hCDC4 can cause chromosomal instability , 2004, Nature.

[6]  L. Kersun,et al.  Secondary malignant neoplasms of the bladder after cyclophosphamide treatment for childhood acute lymphocytic leukemia , 2004, Pediatric blood & cancer.

[7]  M. Nowak,et al.  Linear Model of Colon Cancer Initiation , 2004, Cell cycle.

[8]  Raghu Kalluri,et al.  Cancer without disease , 2004, Nature.

[9]  R. Perona,et al.  Control of oncogenesis and cancer therapy resistance , 2004, British Journal of Cancer.

[10]  S. S. Zhang,et al.  DNA repair and cancer: Lessons from mutant mouse models , 2004, Cancer science.

[11]  P. Krammer,et al.  Apoptosis in cancer--implications for therapy. , 2004, Seminars in oncology.

[12]  A. Feinberg,et al.  The history of cancer epigenetics , 2004, Nature Reviews Cancer.

[13]  P. Duesberg,et al.  Aneuploidy, the Primary Cause of the Multilateral Genomic Instability of Neoplastic and Preneoplastic Cells , 2004, IUBMB life.

[14]  A. Jemal,et al.  Cancer Statistics, 2004 , 2004, CA: a cancer journal for clinicians.

[15]  D. Livermore Can better prescribing turn the tide of resistance? , 2004, Nature Reviews Microbiology.

[16]  C. Desmaze,et al.  Telomeres and chromosomal instability , 2004, Cellular and Molecular Life Sciences CMLS.

[17]  M. Digweed Response to environmental carcinogens in DNA-repair-deficient disorders. , 2003, Toxicology.

[18]  O. Sieber,et al.  Genomic instability — the engine of tumorigenesis? , 2003, Nature Reviews Cancer.

[19]  Martin A. Nowak,et al.  The significance of unstable chromosomes in colorectal cancer , 2003, Nature Reviews Cancer.

[20]  M. Surani,et al.  Specification of germ cell fate in mice. , 2003, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[21]  W. Wayt Gibbs,et al.  Untangling the roots of cancer. , 2003, Scientific American.

[22]  R. Ulanowicz On the Ordinality of Causes in Complex Autocatalytic Systems , 2003, Annals of the New York Academy of Sciences.

[23]  C. Wilke,et al.  Evolution of mutational robustness. , 2003, Mutation research.

[24]  D. Brisson The Directed Mutation Controversy in an Evolutionary Context , 2003, Critical reviews in microbiology.

[25]  P. Shields,et al.  Food mutagens. , 2003, Journal of NutriLife.

[26]  D. Gisselsson Chromosome instability in cancer: how, when, and why? , 2003, Advances in cancer research.

[27]  P. Vineis Cancer as an evolutionary process at the cell level: an epidemiological perspective. , 2003, Carcinogenesis.

[28]  Martin A. Nowak,et al.  The role of chromosomal instability in tumor initiation , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[29]  N. Restifo,et al.  Natural selection of tumor variants in the generation of “tumor escape” phenotypes , 2002, Nature Immunology.

[30]  P. Sniegowski,et al.  Fitness evolution and the rise of mutator alleles in experimental Escherichia coli populations. , 2002, Genetics.

[31]  P. Ingvarsson,et al.  Genealogical evidence for epidemics of selfish genes , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[32]  D. Marsh,et al.  Genetic insights into familial cancers-- update and recent discoveries. , 2002, Cancer letters.

[33]  F. Alt,et al.  The Mechanism and Regulation of Chromosomal V(D)J Recombination , 2002, Cell.

[34]  C. Lengauer,et al.  Exploring and Exploiting Instability , 2002, Cancer biology & therapy.

[35]  Hiroyuki Yamamoto,et al.  Gastrointestinal cancer of the microsatellite mutator phenotype pathway , 2002, Journal of Gastroenterology.

[36]  Jarle Breivik,et al.  Self-Organization of Template-Replicating Polymers and the Spontaneous Rise of Genetic Information , 2001, Entropy.

[37]  D. Avgerinos,et al.  Malignant neoplasms: discordance between clinical diagnoses and autopsy findings in 3,118 cases , 2001, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

[38]  M. Blagosklonny,et al.  How carcinogens (or telomere dysfunction) induce genetic instability: associated‐selection model , 2001, FEBS letters.

[39]  S. Palumbi,et al.  Humans as the world's greatest evolutionary force. , 2001, Science.

[40]  J. Breivik Don't stop for repairs in a war zone: Darwinian evolution unites genes and environment in cancer development , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  K. Kinzler,et al.  Carcinogen-specific induction of genetic instability , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[42]  N. Tuteja,et al.  Unraveling DNA Repair in Human: Molecular Mechanisms and Consequences of Repair Defect , 2001, Critical reviews in biochemistry and molecular biology.

[43]  A. Lindblom Different mechanisms in the tumorigenesis of proximal and distal colon cancers , 2001, Current opinion in oncology.

[44]  A. Meadows Second tumours. , 2001, European journal of cancer.

[45]  T. Johnson,et al.  The evolution of mutation rates: separating causes from consequences , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.

[46]  S. Rodin,et al.  Human lung cancer and p53: the interplay between mutagenesis and selection. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Hervé Le Nagard,et al.  Mutators and sex in bacteria: conflict between adaptive strategies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[48]  C. Adami,et al.  Evolution of Biological Complexity , 2000, Proc. Natl. Acad. Sci. USA.

[49]  J W Arends,et al.  Molecular interactions in the Vogelstein model of colorectal carcinoma , 2000, The Journal of pathology.

[50]  S. Lloyd Ultimate physical limits to computation , 1999, Nature.

[51]  N. Janin A simple model for carcinogenesis of colorectal cancers with microsatellite instability. , 2000, Advances in cancer research.

[52]  K. Kinzler,et al.  Genetic instability and darwinian selection in tumours. , 1999, Trends in cell biology.

[53]  H. Rubin Cell damage, aging and transformation: a multilevel analysis of carcinogenesis. , 1999, Anticancer research.

[54]  G. Gaudernack,et al.  Genomic instability, DNA methylation, and natural selection in colorectal carcinogenesis. , 1999, Seminars in cancer biology.

[55]  S. Hecht,et al.  Tobacco smoke carcinogens and lung cancer. , 1999, Journal of the National Cancer Institute.

[56]  G. Gaudernack,et al.  Carcinogenesis and natural selection: a new perspective to the genetics and epigenetics of colorectal cancer. , 1999, Advances in cancer research.

[57]  K. Kinzler,et al.  Genetic instabilities in human cancers , 1998, Nature.

[58]  I. Arzimanoglou,et al.  Microsatellite instability in human solid tumors , 1998, Cancer.

[59]  C. Adami,et al.  Introduction To Artificial Life , 1997, IEEE Trans. Evol. Comput..

[60]  L. Loeb,et al.  Cancer cells exhibit a mutator phenotype. , 1998, Advances in cancer research.

[61]  G. Klein Foulds' dangerous idea revisited: the multistep development of tumors 40 years later. , 1998, Advances in cancer research.

[62]  A. Børresen-Dale,et al.  Different genetic pathways to proximal and distal colorectal cancer influenced by sex‐related factors , 1997, International journal of cancer.

[63]  S. Rosenberg Mutation for survival. , 1997, Current opinion in genetics & development.

[64]  K. Kinzler,et al.  Genetic instability in colorectal cancers , 1997, Nature.

[65]  E. Mayr,et al.  The objects of selection. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[66]  J C Reed,et al.  Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator Phenotype , 1997, Science.

[67]  K. Kinzler,et al.  Cancer-susceptibility genes. Gatekeepers and caretakers. , 1997, Nature.

[68]  O. Nanni,et al.  Microsatellite instability and mutations of p53 and TGF-‚RII genes in gastric cancer , 1996, Human Genetics.

[69]  J. Doonan,et al.  Why don't plants get cancer? , 1996, Nature.

[70]  P. Karran,et al.  Genomic instability and tolerance to alkylating agents. , 1996, Cancer surveys.

[71]  J. Doonan,et al.  Cell cycle. Why don't plants get cancer? , 1996, Nature.

[72]  V. Bohr DNA repair fine structure and its relations to genomic instability. , 1995, Carcinogenesis.

[73]  D. Dennett Darwin's Dangerous Idea: Evolution and the Meanings of Life , 1995 .

[74]  M. Churchill,et al.  DNA chaperones: A solution to a persistence problem? , 1994, Cell.

[75]  Robin J. Leach,et al.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.

[76]  L. Aaltonen,et al.  Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. , 1993, Cancer research.

[77]  K. Kinzler,et al.  The multistep nature of cancer. , 1993, Trends in genetics : TIG.

[78]  N. Copeland,et al.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. , 1993, Cell.

[79]  G. Chenevix-Trench,et al.  Genomic instability occurs in colorectal carcinomas but not in adenomas , 1993, Human mutation.

[80]  L. Loeb,et al.  Mutator phenotype may be required for multistage carcinogenesis. , 1991, Cancer research.

[81]  H. Jane Brockmann,et al.  The selfish gene (2nd edn) , 1990 .

[82]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[83]  P. Anthony Robbins' Pathologic Basis of Disease , 1990 .

[84]  N. Dubrawsky Cancer statistics , 1989, CA: a cancer journal for clinicians.

[85]  S. Robbins,et al.  Pathologic basis of disease , 1974 .

[86]  W. O. Williams,et al.  NATURAL history of cancer. , 1963, British medical journal.

[87]  L. Foulds,et al.  The natural history of cancer. , 1958, Journal of chronic diseases.