Mechanisms of auxin signaling

The plant hormone auxin triggers complex growth and developmental processes. Its underlying molecular mechanism of action facilitates rapid switching between transcriptional repression and gene activation through the auxin-dependent degradation of transcriptional repressors. The nuclear auxin signaling pathway consists of a small number of core components. However, in most plants each component is represented by a large gene family. The modular construction of the pathway can thus produce diverse transcriptional outputs depending on the cellular and environmental context. Here, and in the accompanying poster, we outline the current model for TIR1/AFB-dependent auxin signaling with an emphasis on recent studies. Summary: This poster article provides an overview of the auxin signal transduction pathway, highlighting how it facilitates rapid switching between transcriptional repression and gene activation.

[1]  J. Bowman,et al.  A Simple Auxin Transcriptional Response System Regulates Multiple Morphogenetic Processes in the Liverwort Marchantia polymorpha , 2015, PLoS genetics.

[2]  D. Wagner,et al.  SPLAYED, a Novel SWI/SNF ATPase Homolog, Controls Reproductive Development in Arabidopsis , 2002, Current Biology.

[3]  K. Dreher,et al.  The Arabidopsis Aux/IAA Protein Family Has Diversified in Degradation and Auxin Responsiveness[W] , 2006, The Plant Cell Online.

[4]  Max H Nanao,et al.  Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression , 2014, Proceedings of the National Academy of Sciences.

[5]  G. Hagen,et al.  Composite structure of auxin response elements. , 1995, The Plant cell.

[6]  Christophe Godin,et al.  The auxin signalling network translates dynamic input into robust patterning at the shoot apex , 2011, Molecular systems biology.

[7]  M. Estelle,et al.  The F-box protein TIR1 is an auxin receptor , 2005, Nature.

[8]  Jun Xiao,et al.  Auxin-regulated chromatin switch directs acquisition of flower primordium founder fate , 2015, eLife.

[9]  G. Hagen,et al.  The Roles of Auxin Response Factor Domains in Auxin-Responsive Transcription Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.008417. , 2003, The Plant Cell Online.

[10]  Sateesh Kagale,et al.  EAR motif-mediated transcriptional repression in plants , 2011, Epigenetics.

[11]  D. Weijers,et al.  Auxin control of embryo patterning. , 2009, Cold Spring Harbor perspectives in biology.

[12]  Michal Sharon,et al.  Mechanism of auxin perception by the TIR1 ubiquitin ligase , 2007, Nature.

[13]  M. Terrile,et al.  Nitric oxide influences auxin signaling through S-nitrosylation of the Arabidopsis TRANSPORT INHIBITOR RESPONSE 1 auxin receptor. , 2012, The Plant journal : for cell and molecular biology.

[14]  M. Umeda,et al.  Hormonal control of cell division and elongation along differentiation trajectories in roots. , 2014, Journal of Experimental Botany.

[15]  T. Guilfoyle.  The PB1 Domain in Auxin Response Factor and Aux/IAA Proteins: A Versatile Protein Interaction Module in the Auxin Response[OPEN] , 2015, Plant Cell.

[16]  G. Jürgens,et al.  Patterning the axis in plants--auxin in control. , 2007, Current opinion in genetics & development.

[17]  Yunde Zhao.  Auxin biosynthesis and its role in plant development. , 2010, Annual review of plant biology.

[18]  M. Estelle,et al.  Diversity and specificity: auxin perception and signaling through the TIR1/AFB pathway. , 2014, Current opinion in plant biology.

[19]  Teva Vernoux,et al.  Auxin at the shoot apical meristem. , 2010, Cold Spring Harbor perspectives in biology.

[20]  Iain W. Manfield,et al.  Structural Basis for DNA Binding Specificity by the Auxin-Dependent ARF Transcription Factors , 2014, Cell.

[21]  J. Banks.  Selaginella and 400 million years of separation. , 2009, Annual review of plant biology.

[22]  J. Nemhauser,et al.  Untethering the TIR1 auxin receptor from the SCF complex increases its stability and inhibits auxin response. , 2015, Nature plants.

[23]  Iktae Kim,et al.  Structural basis for the auxin-induced transcriptional regulation by Aux/IAA17 , 2014, Proceedings of the National Academy of Sciences.

[24]  J. Long,et al.  TOPLESS Mediates Auxin-Dependent Transcriptional Repression During Arabidopsis Embryogenesis , 2008, Science.

[25]  M. Braun,et al.  Plasma Membrane-Targeted PIN Proteins Drive Shoot Development in a Moss , 2014, Current Biology.

[26]  M. Estelle,et al.  SCFTIR1/AFB-Based Auxin Perception: Mechanism and Role in Plant Growth and Development , 2015, Plant Cell.

[27]  C. D. de Oliveira,et al.  A combinatorial TIR1/AFB-Aux/IAA co-receptor system for differential sensing of auxin , 2012, Nature chemical biology.

[28]  L. Strader,et al.  Refining the nuclear auxin response pathway through structural biology. , 2015, Current opinion in plant biology.

[29]  C. Perrot-Rechenmann,et al.  Cellular responses to auxin: division versus expansion. , 2010, Cold Spring Harbor perspectives in biology.

[30]  Stefan Kepinski,et al.  HSP90 regulates temperature-dependent seedling growth in Arabidopsis by stabilizing the auxin co-receptor F-box protein TIR1 , 2016, Nature Communications.

[31]  A. Murphy,et al.  Auxin transporters--why so many? , 2010, Cold Spring Harbor perspectives in biology.

[32]  Ottoline Leyser,et al.  The Arabidopsis F-box protein TIR1 is an auxin receptor , 2005, Nature.

[33]  T. Kohchi,et al.  Auxin-Mediated Transcriptional System with a Minimal Set of Components Is Critical for Morphogenesis through the Life Cycle in Marchantia polymorpha , 2015, PLoS genetics.

[34]  J. Nemhauser,et al.  Rate Motifs Tune Auxin/Indole-3-Acetic Acid Degradation Dynamics1[OPEN] , 2015, Plant Physiology.

[35]  M. Terrile,et al.  MiR393 Regulation of Auxin Signaling and Redox-Related Components during Acclimation to Salinity in Arabidopsis , 2014, PloS one.

[36]  Teva Vernoux,et al.  Reporters for sensitive and quantitative measurement of auxin response , 2015, Nature Methods.

[37]  G. Hagen,et al.  Activation and repression of transcription by auxin-response factors. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[38]  Xiaolu Yang,et al.  Peptidyl-prolyl isomerization targets rice Aux/IAAs for proteasomal degradation during auxin signalling , 2015, Nature Communications.

[39]  T. A. Walsh,et al.  Mutations in an Auxin Receptor Homolog AFB5 and in SGT1b Confer Resistance to Synthetic Picolinate Auxins and Not to 2,4-Dichlorophenoxyacetic Acid or Indole-3-Acetic Acid in Arabidopsis[W] , 2006, Plant Physiology.

[40]  Ben Scheres,et al.  Auxin: the looping star in plant development. , 2008, Annual review of plant biology.

[41]  J. Bowman,et al.  The Arabidopsis thaliana SNF2 homolog AtBRM controls shoot development and flowering , 2004, Development.

[42]  M. Estelle,et al.  Report Physcomitrella Patens Auxin-resistant Mutants Affect Conserved Elements of an Auxin-signaling Pathway , 2022 .

[43]  miR393: Integrator of environmental cues in auxin signaling? , 2011, Plant signaling & behavior.

[44]  Eric Klavins,et al.  A Synthetic Approach Reveals Extensive Tunability of Auxin Signaling1[C][W][OA] , 2012, Plant Physiology.