apoE 4 allele and the natural history of cardiovascular risk factors

Angelo Scuteri, Samer S. Najjar, Denis Muller, Reubin Andres, Christopher H. Morrell, Alan B. Zonderman, and Edward G. Lakatta Laboratory of Cardiovascular Science, Clinical Research Branch, Laboratory of Clinical Investigation, and Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Baltimore, Maryland; Unità Operativa Geriatria, Istituto Nazionale Ricovero e Cura per Anziani Rome, Italy; and Loyola College in Maryland, Baltimore, Maryland

[1]  P. Stiefel,et al.  Apolipoprotein E gene polymorphism is related to metabolic abnormalities, but does not influence erythrocyte membrane lipid composition or sodium-lithium countertransport activity in essential hypertension. , 2001, Metabolism: clinical and experimental.

[2]  J. Ordovás,et al.  The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle. , 1999, Atherosclerosis.

[3]  D. Singer,et al.  Apolipoprotein E isoform polymorphisms are not associated with insulin resistance: the Framingham Offspring Study. , 2000, Diabetes care.

[4]  V. Ord,et al.  ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[5]  Charles F. Sing,et al.  An ecological study of association between coronary heart disease mortality rates in men and the relative frequencies of common allelic variations in the gene coding for apolipoprotein E , 1998, Human Genetics.

[6]  J. Thijssen,et al.  Extensive islet amyloid formation is induced by development of Type II diabetes mellitus and contributes to its progression: pathogenesis of diabetes in a mouse model , 1999, Diabetologia.

[7]  M. Linton,et al.  Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[8]  T. Arinami,et al.  Methylenetetrahydrofolate reductase and apolipoprotein E polymorphisms are independent risk factors for coronary heart disease in Japanese: a case-control study. , 1998, Atherosclerosis.

[9]  F. Baralle,et al.  Polymorphism of the apolipoprotein E gene and early carotid atherosclerosis defined by ultrasonography in asymptomatic adults. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[10]  Y. Kesäniemi,et al.  Gallstone cholesterol content is related to apolipoprotein E polymorphism. , 1993, Gastroenterology.

[11]  Christopher H. Morrell,et al.  Linear Transformations of Linear Mixed-Effects Models , 1997 .

[12]  T. Hayek,et al.  Increased plasma and lipoprotein lipid peroxidation in apo E-deficient mice. , 1994, Biochemical and biophysical research communications.

[13]  E. Barrett-Connor,et al.  Apolipoprotein E polymorphism and lipid levels differ by gender and family history of diabetes: the Rancho Bernardo Study , 2001, Clinical genetics.

[14]  J. Hixson.  Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

[15]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[16]  E. D. de Koning,et al.  Intra- and extracellular amyloid fibrils are formed in cultured pancreatic islets of transgenic mice expressing human islet amyloid polypeptide. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[17]  P A Wolf,et al.  Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study. , 1994, JAMA.

[18]  L. Kuller,et al.  Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. , 1993, The American journal of cardiology.

[19]  T. Wisniewski,et al.  The interaction between apolipoprotein E and Alzheimer's amyloid beta-peptide is dependent on beta-peptide conformation. , 1996, The Journal of biological chemistry.

[20]  Ana Ivelisse Avilés,et al.  Linear Mixed Models for Longitudinal Data , 2001, Technometrics.

[21]  J. Krystal,et al.  Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. , 2004, Archives of general psychiatry.

[22]  T Vogel,et al.  Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro. , 1994, The American journal of pathology.

[23]  J. Bernhagen,et al.  Contribution of advanced glycosylation to the amyloidogenicity of islet amyloid polypeptide. , 1998, European journal of biochemistry.

[24]  B. Ahrén,et al.  Islet amyloid and type 2 diabetes mellitus. , 2000, The New England journal of medicine.

[25]  M. Woodward,et al.  Blood glucose and risk of cardiovascular disease in the Asia Pacific region. , 2004, Diabetes care.

[26]  R. Frikke-Schmidt,et al.  Apolipoprotein E genotype: epsilon32 women are protected while epsilon43 and epsilon44 men are susceptible to ischemic heart disease: the Copenhagen City Heart Study. , 2000, Journal of the American College of Cardiology.

[27]  C. Sing,et al.  Apolipoprotein E polymorphism and atherosclerosis. , 1988, Arteriosclerosis.

[28]  J. Stengård,et al.  Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. , 1995, Circulation.

[29]  D. T. Vernier,et al.  Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. , 1990, Journal of lipid research.

[30]  I. Rossman,et al.  Normal Human Aging: The Baltimore Longitudinal Study of Aging , 1986 .

[31]  M. Hayden,et al.  Islet amyloid, metabolic syndrome, and the natural progressive history of type 2 diabetes mellitus. , 2002, JOP : Journal of the pancreas.

[32]  J. Fleg,et al.  Is the apoE4 allele an independent predictor of coronary events? , 2001, The American journal of medicine.

[33]  R. T. Carroll,et al.  Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. , 1997, The American journal of pathology.

[34]  H. Blackburn,et al.  Cardiovascular survey methods. , 1969, East African medical journal.

[35]  Michele Muggeo,et al.  Population-based incidence rates and risk factors for type 2 diabetes in white individuals: the Bruneck study. , 2004, Diabetes.

[36]  J. Dallongeville.  Apolipoprotéine E: propriétés physiologiques, polymorphisme et athérosclérose , 1993 .

[37]  S. Laurent,et al.  Glucose level is a major determinant of carotid intima–media thickness in patients with hypertension and hyperglycemia , 2004, Journal of hypertension.

[38]  D. Gómez-Coronado,et al.  Apolipoprotein E polymorphism in men and women from a Spanish population: allele frequencies and influence on plasma lipids and apolipoproteins. , 1999, Atherosclerosis.

[39]  G. Siest,et al.  Early-glycation of apolipoprotein E: effect on its binding to LDL receptor, scavenger receptor A and heparan sulfates. , 2002, Biochimica et biophysica acta.

[40]  L. Bernier,et al.  Apolipoprotein E and atherosclerosis: insight from animal and human studies. , 1999, Clinica chimica acta; international journal of clinical chemistry.