A method of retinal vessel width measurement

According to Gaussian model of retinal blood vessel profile, a retinal vessel blood diameter automatic measurement method is proposed based on the gray-scale image. This method does not need segment and binary operation, it directly finds the rough location of the center points of ROI region, which is operated in column and row respectively, and then using the eigenvectors of Hessian matrix to determine the blood vessels radial direction, at last fitting its radial gray values with least-squares. The process is repeated until the central point convergence. Finally the diameter of blood vessel is determined by finding the knee point. To enhance the robustness of the algorithm, the weighted average of five adjacent diameters are used to replace the diameter of the test points. Experimental results show that the method is stable, simple and effective.