Rational engineering of glycosaminoglycan-based Dickkopf-1 scavengers to improve bone regeneration.
暂无分享,去创建一个
M. Schnabelrauch | J. Rademann | M. T. Pisabarro | S. Moeller | S. Rother | V. Hintze | Sophie Pählig | C. Hofbauer | K. Balamurugan | J. Salbach-Hirsch | G. Furesi | L. Köhler | M. Pisabarro | Jan-Niklas Dürig | L. Hofbauer | Gloria Ruiz-Gómez | Pedro M. Guillem-Gloria | Sophie-Luise Heidig | J. Salbach‐Hirsch | Giulia Furesi | P. M. Guillem-Gloria
[1] L. Hofbauer,et al. New insights into the role of glycosaminoglycans in the endosteal bone microenvironment , 2021, Biological chemistry.
[2] H. Taipaleenmäki,et al. Osteoporosis Treatment with Anti-Sclerostin Antibodies—Mechanisms of Action and Clinical Application , 2021, Journal of clinical medicine.
[3] A. E. El Haj,et al. Wnt-modified materials mediate asymmetric stem cell division to direct human osteogenic tissue formation for bone repair , 2020, Nature Materials.
[4] Shiaw-Min Hwang,et al. Coactivation of Endogenous Wnt10b and Foxc2 by CRISPR Activation Enhances BMSC Osteogenesis and Promotes Calvarial Bone Regeneration. , 2019, Molecular therapy : the journal of the American Society of Gene Therapy.
[5] S. Djordjević,et al. Dual Action of Sulfated Hyaluronan on Angiogenic Processes in Relation to Vascular Endothelial Growth Factor-A , 2019, Scientific Reports.
[6] J. Takagi,et al. Crystal structure of a mammalian Wnt–frizzled complex , 2019, Nature Structural & Molecular Biology.
[7] F. Siemers,et al. Wnt Pathway in Bone Repair and Regeneration – What Do We Know So Far , 2019, Front. Cell Dev. Biol..
[8] A. Beck‐Sickinger,et al. Syntheses of defined sulfated oligohyaluronans reveal structural effects, diversity and thermodynamics of GAG–protein binding† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc03649g , 2018, Chemical science.
[9] A. V. van Wijnen,et al. A Versatile Protocol for Studying Calvarial Bone Defect Healing in a Mouse Model. , 2017, Tissue engineering. Part C, Methods.
[10] A. Grauer,et al. Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis , 2017, The New England journal of medicine.
[11] Susan Y. Smith,et al. Romosozumab Improves Bone Mass and Strength While Maintaining Bone Quality in Ovariectomized Cynomolgus Monkeys , 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[12] C. Cooper,et al. Identification and management of patients at increased risk of osteoporotic fracture: outcomes of an ESCEO expert consensus meeting , 2017, Osteoporosis International.
[13] L. Hofbauer,et al. Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function. , 2016, Biomaterials.
[14] W. Richards,et al. A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair , 2016, Nature Communications.
[15] D. Huster,et al. Chemoenzymatic Synthesis of Nonasulfated Tetrahyaluronan with a Paramagnetic Tag for Studying Its Complex with Interleukin-10. , 2016, Chemistry.
[16] L. Hofbauer,et al. Structural and functional insights into sclerostin-glycosaminoglycan interactions in bone. , 2015, Biomaterials.
[17] T. Rachner,et al. Glycosaminoglycans and their sulfate derivatives differentially regulate the viability and gene expression of osteocyte-like cell lines , 2014 .
[18] M. Anselmi,et al. Sulfated glycosaminoglycans exploit the conformational plasticity of bone morphogenetic protein-2 (BMP-2) and alter the interaction profile with its receptor. , 2014, Biomacromolecules.
[19] S. Samsonov,et al. Artificial extracellular matrix composed of collagen I and highly sulfated hyaluronan interferes with TGFβ(1) signaling and prevents TGFβ(1)-induced myofibroblast differentiation. , 2013, Acta biomaterialia.
[20] J. Delaissé,et al. Understanding coupling between bone resorption and formation: are reversal cells the missing link? , 2013, The American journal of pathology.
[21] Woody Sherman,et al. Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments , 2013, Journal of Computer-Aided Molecular Design.
[22] T. Rachner,et al. The effect of the degree of sulfation of glycosaminoglycans on osteoclast function and signaling pathways. , 2012, Biomaterials.
[23] Holger Gohlke,et al. MMPBSA.py: An Efficient Program for End-State Free Energy Calculations. , 2012, Journal of chemical theory and computation.
[24] J. Mao,et al. Structural and functional studies of LRP6 ectodomain reveal a platform for Wnt signaling. , 2011, Developmental cell.
[25] W. Weis,et al. Structural basis of Wnt signaling inhibition by Dickkopf binding to LRP5/6. , 2011, Developmental cell.
[26] R. Moon,et al. Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 , 2011, Nature Structural &Molecular Biology.
[27] E. Bourhis,et al. Wnt antagonists bind through a short peptide to the first β-propeller domain of LRP5/6. , 2011, Structure.
[28] Arun K Gosain,et al. Testing the Critical Size in Calvarial Bone Defects: Revisiting the Concept of a Critical-Size Defect , 2010, Plastic and reconstructive surgery.
[29] M. Viola,et al. Modifications of hyaluronan influence the interaction with human bone morphogenetic protein-4 (hBMP-4). , 2009, Biomacromolecules.
[30] Etienne Weiss,et al. Therapeutic antibodies: successes, limitations and hopes for the future , 2009, British journal of pharmacology.
[31] P. Slocombe,et al. Characterization of the Structural Features and Interactions of Sclerostin , 2009, Journal of Biological Chemistry.
[32] Qing Chen,et al. Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis , 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[33] Spencer J. Williams,et al. 'Click' cycloaddition catalysts: copper(I) and copper(II) tris(triazolylmethyl)amine complexes. , 2008, Chemical communications.
[34] Karl Nicholas Kirschner,et al. GLYCAM06: A generalizable biomolecular force field. Carbohydrates , 2008, J. Comput. Chem..
[35] S. Janz,et al. Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF , 2007, Molecular Cancer.
[36] Jeremy R. Greenwood,et al. Epik: a software program for pKa prediction and protonation state generation for drug-like molecules , 2007, J. Comput. Aided Mol. Des..
[37] David E. Shaw,et al. PHASE: a new engine for pharmacophore perception, 3D QSAR model development, and 3D database screening: 1. Methodology and preliminary results , 2006, J. Comput. Aided Mol. Des..
[38] Junmei Wang,et al. Development and testing of a general amber force field , 2004, J. Comput. Chem..
[39] Hege S. Beard,et al. Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening. , 2004, Journal of medicinal chemistry.
[40] Matthew P. Repasky,et al. Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. , 2004, Journal of medicinal chemistry.
[41] P. Kollman,et al. Use of MM-PBSA in reproducing the binding free energies to HIV-1 RT of TIBO derivatives and predicting the binding mode to HIV-1 RT of efavirenz by docking and MM-PBSA. , 2001, Journal of the American Chemical Society.
[42] R. Friesner,et al. Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides† , 2001 .
[43] David S. Goodsell,et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function , 1998, J. Comput. Chem..
[44] K Schulten,et al. VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.
[45] Cornelis Altona,et al. Force field parameters for sulfates and sulfamates based on ab initio calculations: Extensions of AMBER and CHARMm fields , 1995, J. Comput. Chem..
[46] T. Riemer,et al. Sulfated hyaluronan derivatives reduce the proliferation rate of primary rat calvarial osteoblasts , 2009, Glycoconjugate Journal.