Circular RNAs and gastrointestinal cancers: Epigenetic regulators with a prognostic and therapeutic role.

[1]  Xiao-Guang Xu,et al.  circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth. , 2020, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[2]  Yulan Yan,et al.  Next-generation sequencing reveals hsa_circ_0058092 being a potential oncogene candidate involved in gastric cancer. , 2020, Gene.

[3]  Lan Liu,et al.  Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway. , 2020, Biochemical and biophysical research communications.

[4]  Anding Xu,et al.  The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function , 2020, Journal of neuroscience research.

[5]  Meijuan Huang,et al.  Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway. , 2019, Hepatobiliary & pancreatic diseases international : HBPD INT.

[6]  Xiao-Ya Su,et al.  Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182/NPTX1 axis. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[7]  Yingwei Xue,et al.  Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer , 2019, Journal of Investigative Medicine.

[8]  F. Qi,et al.  Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer , 2019, Cancer Cell International.

[9]  Peng Zhang,et al.  Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma , 2019, Cancer Cell International.

[10]  Junming Guo,et al.  Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma , 2019, Cancer medicine.

[11]  Pei Jiang,et al.  Clinical value of circular RNAs and autophagy-related miRNAs in the diagnosis and treatment of pancreatic cancer. , 2019, Hepatobiliary & pancreatic diseases international : HBPD INT.

[12]  Qian Yang,et al.  Identification of hsa_circ_0001821 as a Novel Diagnostic Biomarker in Gastric Cancer via Comprehensive Circular RNA Profiling , 2019, Front. Genet..

[13]  Lin-pei Wang,et al.  Circ_SPECC1 enhances the inhibition of miR-526b on downstream KDM4A/YAP1 pathway to regulate the growth and invasion of gastric cancer cells. , 2019, Biochemical and biophysical research communications.

[14]  Ling Lin,et al.  Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma , 2019, Cell cycle.

[15]  Shegan Gao,et al.  Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic cancer progression through miR-137-3p/PTN axis. , 2019, Life sciences.

[16]  Chang-ming Huang,et al.  Circular RNA hsa_circ_0006848 Related to Ribosomal Protein L6 Acts as a Novel Biomarker for Early Gastric Cancer , 2019, Disease markers.

[17]  Yijiang Chen,et al.  hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[18]  Chen Huang,et al.  Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis , 2019, Molecular Cancer.

[19]  Y. Shao,et al.  Hsa_circ_0065149 is an Indicator for Early Gastric Cancer Screening and Prognosis Prediction , 2019, Pathology & Oncology Research.

[20]  Juan Tian,et al.  Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT , 2019, Journal of clinical laboratory analysis.

[21]  Juan Cai,et al.  circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating β-catenin/c-Myc signaling , 2019, Cell Death & Disease.

[22]  Xue Zhou,et al.  The role of circular RNA hsa_circ_0085616 in proliferation and migration of hepatocellular carcinoma cells , 2019, Cancer management and research.

[23]  Wenjing Chen,et al.  [Role of miRNA-340 in modulating gastric cancer cell proliferation and bioinformatic analysis]. , 2019, Nan fang yi ke da xue xue bao = Journal of Southern Medical University.

[24]  Qiwei Yang,et al.  Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma , 2019, Journal of oncology.

[25]  Y. Shao,et al.  Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues , 2019, Journal of clinical laboratory analysis.

[26]  Guang-lei Qiao,et al.  Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma , 2019, OncoTargets and therapy.

[27]  Guanqun Huang,et al.  Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR‐195/GPRC5A signalling , 2019, Cell proliferation.

[28]  Jianjun Luo,et al.  CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway. , 2019, Clinical science.

[29]  Yu Yang,et al.  Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer. , 2019, Experimental and molecular pathology.

[30]  M. Dong,et al.  Role of circular RNAs in gastric cancer: Recent advances and prospects , 2019, World journal of gastrointestinal oncology.

[31]  D. Gao,et al.  Circular RNA circTRIM33–12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression , 2019, Molecular Cancer.

[32]  Hao Zhou,et al.  CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis. , 2019, Biochemical and biophysical research communications.

[33]  Lei Gao,et al.  Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway , 2019, Bioscience reports.

[34]  Juan Cai,et al.  circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer , 2019, Disease markers.

[35]  Xiu-feng Cao,et al.  Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[36]  M. Schatz,et al.  Novel circular RNA NF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. , 2019, Endocrine-related cancer.

[37]  Peng Wang,et al.  CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth , 2019, Journal of Experimental & Clinical Cancer Research.

[38]  G. Goodall,et al.  Insights into the biogenesis and potential functions of exonic circular RNA , 2019, Scientific Reports.

[39]  Hansi Liang,et al.  A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. , 2019, Cancer letters.

[40]  Yunfu Cui,et al.  Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294. , 2019, Biochemical and biophysical research communications.

[41]  Q. Cao,et al.  Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis , 2019, Molecular Cancer.

[42]  Hanchen Xu,et al.  RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers , 2019, Molecular Cancer.

[43]  Wei Liu,et al.  Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a–MET pathway , 2019, EBioMedicine.

[44]  Jun Chen,et al.  A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma , 2019, Cancer management and research.

[45]  Liye Ma,et al.  The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma , 2019, Biology Open.

[46]  H. El‐Serag,et al.  Epidemiology and Management of Hepatocellular Carcinoma. , 2019, Gastroenterology.

[47]  A. Jemal,et al.  Cancer statistics, 2019 , 2019, CA: a cancer journal for clinicians.

[48]  Chenyue Zhang,et al.  Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma , 2018, Oncology letters.

[49]  Tao Mao,et al.  Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR‐106b‐5p , 2018, Journal of cellular biochemistry.

[50]  Qian Zhang,et al.  Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma , 2018, Digestive Diseases and Sciences.

[51]  Xiang-Nan Li,et al.  RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer , 2018, Journal of Experimental & Clinical Cancer Research.

[52]  Jiali Yang,et al.  Retraction notice to "Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression" [Cancer Letters 422C (2018) 70-80]. , 2018, Cancer letters.

[53]  Xiaozhou He,et al.  circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer , 2018, Cellular Physiology and Biochemistry.

[54]  Chang-ming Huang,et al.  Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer , 2018, Journal of clinical laboratory analysis.

[55]  P. Gallo,et al.  Promoting genetics in non-alcoholic fatty liver disease: Combined risk score through polymorphisms and clinical variables , 2018, World journal of gastroenterology.

[56]  Xiaodong Guo,et al.  CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR‐186‐5p and modulating NEK2 , 2018, Journal of cellular physiology.

[57]  Liang Wang,et al.  Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1 , 2018, Cell & Bioscience.

[58]  Yuanchun Li,et al.  Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR‐625 and miR‐892b , 2018, Journal of cellular biochemistry.

[59]  Chenyue Zhang,et al.  Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma , 2018, Cellular Physiology and Biochemistry.

[60]  Chungang Liu,et al.  Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge , 2018, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[61]  Xiufeng,et al.  Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression , 2018, Cancer management and research.

[62]  Linbo Liu,et al.  Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR‐136/SH2B1 axis , 2018, Journal of cellular physiology.

[63]  Hui Liu,et al.  Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis , 2018, Molecular Cancer.

[64]  Yan Zhang,et al.  CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer , 2018, Journal of biochemistry.

[65]  Li Yan,et al.  A novel prognostic biomarker for pancreatic ductal adenocarcinoma: hsa_circ_0001649. , 2018, Gene.

[66]  Yan Zhang,et al.  CircRNA CDR1as/miR-7 signals promote tumor growth of osteosarcoma with a potential therapeutic and diagnostic value , 2018, Cancer management and research.

[67]  Yi Sun,et al.  Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p / FOXO4 axis. , 2018, Biochemical and biophysical research communications.

[68]  Yun-Jing Huang,et al.  Circular RNA 101368/miR-200a axis modulates the migration of hepatocellular carcinoma through HMGB1/RAGE signaling , 2018, Cell cycle.

[69]  Weiwei Tang,et al.  CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer , 2018, Molecular Cancer.

[70]  A. Azmi Nuclear export mechanisms of circular RNAs: size does matter. , 2018, Non-coding RNA investigation.

[71]  Jia-hua Hu,et al.  Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. , 2018, Epigenomics.

[72]  Lei Zheng,et al.  The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells , 2018, Cellular Physiology and Biochemistry.

[73]  Bing Hu,et al.  CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/β-catenin signaling. , 2018, Biochemical and biophysical research communications.

[74]  Yuan Yuan,et al.  CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31. , 2018, Biochemical and biophysical research communications.

[75]  Y. Liao,et al.  Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124. , 2018, Biochemical and biophysical research communications.

[76]  Jin Zhu,et al.  Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer. , 2018, Cancer letters.

[77]  A. Asokan,et al.  Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo , 2018, Molecular therapy. Nucleic acids.

[78]  Jianming Zhang,et al.  Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7 , 2018, The Journal of pathology.

[79]  Hao Xu,et al.  Regulatory network of circRNA–miRNA–mRNA contributes to the histological classification and disease progression in gastric cancer , 2018, Journal of Translational Medicine.

[80]  Jinyun Li,et al.  The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer , 2018, Cancer management and research.

[81]  Xiang Li,et al.  The Biogenesis, Functions, and Challenges of Circular RNAs. , 2018, Molecular cell.

[82]  Xiaowu Li,et al.  Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis , 2018, Journal of Experimental & Clinical Cancer Research.

[83]  Xiu-feng Cao,et al.  Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells , 2018, Scientific Reports.

[84]  Jianming Wang,et al.  Profiles of differentially expressed circRNAs in esophageal and breast cancer , 2018, Cancer management and research.

[85]  P. Zhu,et al.  Preliminary investigation of the function of hsa_circ_0006215 in pancreatic cancer. , 2018, Oncology letters.

[86]  Meijuan Huang,et al.  Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma , 2018, Front. Pharmacol..

[87]  Z. Dongsheng,et al.  Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[88]  Haoran Hu,et al.  Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer , 2018, Journal of clinical laboratory analysis.

[89]  Shuhan Sun,et al.  Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma. , 2018, Journal of hepatology.

[90]  Z. Fu,et al.  Gene microarray analysis of the circular RNAs expression profile in human gastric cancer. , 2018, Oncology letters.

[91]  Jiali Yang,et al.  Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression. , 2018, Cancer letters.

[92]  Liying Zhu,et al.  Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway. , 2018, Biochemical and biophysical research communications.

[93]  B. Xiao,et al.  Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis , 2018, Journal of clinical laboratory analysis.

[94]  Weiwei Tang,et al.  Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells , 2018, OncoTargets and therapy.

[95]  B. Xiao,et al.  Clinical values of circular RNA 0000181 in the screening of gastric cancer , 2018, Journal of clinical laboratory analysis.

[96]  D. Tatomer,et al.  A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs , 2018, Genes & development.

[97]  Z. Zeng,et al.  Circular RNAs function as ceRNAs to regulate and control human cancer progression , 2018, Molecular Cancer.

[98]  Jiali Yang,et al.  Microarray expression profile analysis of circular RNAs in pancreatic cancer , 2018, Molecular medicine reports.

[99]  Yu-qin Pan,et al.  RETRACTED ARTICLE: CircHIPK3 promotes colorectal cancer growth and metastasis by sponging miR-7 , 2018, Cell Death & Disease.

[100]  David P. Bartel,et al.  A Network of Noncoding Regulatory RNAs Acts in the Mammalian Brain , 2018, Cell.

[101]  Dongwei Zhang,et al.  CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/β-catenin axis. , 2018, Biochemical and biophysical research communications.

[102]  B. Xiao,et al.  Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance , 2018, Journal of clinical laboratory analysis.

[103]  Peter Schmid,et al.  PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer , 2018, Cell reports.

[104]  Shaofeng Wu,et al.  Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer. , 2018, Biochemical and biophysical research communications.

[105]  Qinjie Chu,et al.  The Circular RNA Profiles of Colorectal Tumor Metastatic Cells , 2018, Front. Genet..

[106]  R. Maciejewski,et al.  Gastric cancer: epidemiology, prevention, classification, and treatment , 2018, Cancer management and research.

[107]  B. Xiao,et al.  Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance , 2018, Journal of clinical laboratory analysis.

[108]  Yanting Shi,et al.  circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma , 2018, Cell Death & Disease.

[109]  Jun Wang,et al.  Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[110]  Xiang-Hu He,et al.  LncRNA MALAT1 regulates sepsis‐induced cardiac inflammation and dysfunction via interaction with miR‐125b and p38 MAPK/NF&kgr;B , 2018, International immunopharmacology.

[111]  Shuang Liu,et al.  Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN , 2018, Cancer research and treatment : official journal of Korean Cancer Association.

[112]  Yuanlin Ding,et al.  Overexpression of Circular RNA ciRS‐7 Abrogates the Tumor Suppressive Effect of miR‐7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway , 2018, Journal of cellular biochemistry.

[113]  Peifeng Li,et al.  Biogenesis of circular RNAs and their roles in cardiovascular development and pathology , 2018, The FEBS journal.

[114]  P. Zhu,et al.  Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer , 2017, World journal of gastroenterology.

[115]  W. Gu,et al.  Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis , 2017, EBioMedicine.

[116]  Jianyong Sun,et al.  CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway , 2017, OncoTargets and therapy.

[117]  P. Maiti,et al.  Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin , 2017, Oxidative medicine and cellular longevity.

[118]  L. Holdt,et al.  Molecular roles and function of circular RNAs in eukaryotic cells , 2017, Cellular and Molecular Life Sciences.

[119]  A. Ribeiro-dos-Santos,et al.  The comprehensive expression analysis of circular RNAs in gastric cancer and its association with field cancerization , 2017, Scientific Reports.

[120]  I. Gladhaug,et al.  Pancreatic Cancer Chemoresistance to Gemcitabine , 2017, Cancers.

[121]  Zhixin Chen,et al.  The expression profile and clinical significance of circRNA0003906 in colorectal cancer , 2017, OncoTargets and therapy.

[122]  Wenling Zhang,et al.  Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. , 2017, Cancer biomarkers : section A of Disease markers.

[123]  Z. Qian,et al.  Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b , 2017, Oncotarget.

[124]  J. Kjems,et al.  Circular RNAs in cancer: opportunities and challenges in the field , 2017, Oncogene.

[125]  Xiao-yu Wu,et al.  miR-101-3p Suppresses HOX Transcript Antisense RNA (HOTAIR)-Induced Proliferation and Invasion Through Directly Targeting SRF in Gastric Carcinoma Cells. , 2017, Oncology research.

[126]  Meijuan Huang,et al.  Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer , 2017, World journal of gastroenterology.

[127]  Hui Liu,et al.  Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression , 2017, Molecular Cancer.

[128]  Q. Pan,et al.  circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis , 2017, Oxidative medicine and cellular longevity.

[129]  F. Wang,et al.  Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR‐138 targets TERT and PD‐L1 , 2017, Cell biology international.

[130]  Tao Sun,et al.  Regulatory Role of Circular RNAs and Neurological Disorders , 2017, Molecular Neurobiology.

[131]  E. Wang,et al.  Lasp1 promotes malignant phenotype of non-small-cell lung cancer via inducing phosphorylation of FAK-AKT pathway , 2017, Oncotarget.

[132]  Qiaojia Huang,et al.  Circular RNAs expression profiles in human gastric cancer , 2017, Scientific Reports.

[133]  J. Wilusz Circular RNAs: Unexpected outputs of many protein-coding genes , 2017, RNA biology.

[134]  Fang Tian,et al.  环状RNA CircHIPK3通过miR-379调控IGF1表达促进非小细胞肺癌细胞系NCI-H1299与NCI-H2170的细胞增殖 , 2017, Zhongguo fei ai za zhi = Chinese journal of lung cancer.

[135]  J. Yu,et al.  Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells , 2017, OncoTargets and therapy.

[136]  Zhao-You Tang,et al.  Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma , 2017, Scientific Reports.

[137]  Jun He,et al.  Circular RNAs and cancer. , 2017, Cancer letters.

[138]  Shuijun Zhang,et al.  Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma , 2017, Oncotarget.

[139]  J. Yu,et al.  CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630 , 2017, Aging.

[140]  Y. Shao,et al.  Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[141]  J. Rowe,et al.  Review of hepatocellular carcinoma: Epidemiology, etiology, and carcinogenesis , 2017, Journal of carcinogenesis.

[142]  C. Qian,et al.  Circular RNA circMTO1 acts as the sponge of microRNA‐9 to suppress hepatocellular carcinoma progression , 2017, Hepatology.

[143]  Laising Yen,et al.  Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. , 2017, Cancer research.

[144]  Zhigang Wang,et al.  MiR‐145 inhibits human colorectal cancer cell migration and invasion via PAK4‐dependent pathway , 2017, Cancer medicine.

[145]  R. Sood,et al.  Role of RUNX1 in hematological malignancies. , 2017, Blood.

[146]  Jianming Xu,et al.  Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7 , 2017, OncoTargets and therapy.

[147]  N. Rajewsky,et al.  Translation of CircRNAs , 2017, Molecular cell.

[148]  Junming Guo,et al.  Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma , 2017, Oncotarget.

[149]  Junming Guo,et al.  Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[150]  Yun Chen,et al.  Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer. , 2017, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[151]  Junming Guo,et al.  Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma , 2017, Oncotarget.

[152]  Peng Zhang,et al.  ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways , 2017, Molecular oncology.

[153]  Jianbo Wu,et al.  Identification of differentially expressed circular RNAs in human colorectal cancer , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[154]  Fuhua Liu,et al.  Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology. , 2017, Oncology reports.

[155]  B. Xiao,et al.  Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. , 2017, Clinica chimica acta; international journal of clinical chemistry.

[156]  M. Krasna,et al.  Overview of esophageal cancer. , 2017, Annals of cardiothoracic surgery.

[157]  Jie Chen,et al.  Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer. , 2017, Cancer letters.

[158]  H. Kuwano,et al.  Current Status and Future Prospects for Esophageal Cancer Treatment. , 2017, Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia.

[159]  G. Bernal,et al.  Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells , 2017, World journal of gastrointestinal oncology.

[160]  Toshiyoshi Fujiwara,et al.  Circular RNA ciRS-7—A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer , 2017, Clinical Cancer Research.

[161]  Hao Zhang,et al.  Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance , 2017, Disease markers.

[162]  B. Xiao,et al.  Circular RNA 0000096 affects cell growth and migration in gastric cancer , 2017, British Journal of Cancer.

[163]  M. Hegde,et al.  Detecting APC Gene Mutations in Familial Adenomatous Polyposis (FAP) , 2017, Current protocols in human genetics.

[164]  Elena Cerrada,et al.  Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer , 2017, International journal of molecular sciences.

[165]  Jiani Guo,et al.  Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer , 2016, OncoTargets and therapy.

[166]  Zhengcai Liu,et al.  Circular RNA Expression Profile of Pancreatic Ductal Adenocarcinoma Revealed by Microarray , 2016, Cellular Physiology and Biochemistry.

[167]  R. Chen,et al.  Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation , 2016, Scientific Reports.

[168]  D. Xie,et al.  Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells , 2016, Journal of Translational Medicine.

[169]  Lei Yu,et al.  The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression , 2016, PloS one.

[170]  Jun Zhang,et al.  Diverse alternative back-splicing and alternative splicing landscape of circular RNAs , 2016, Genome research.

[171]  Fengling Wang,et al.  Circular RNAs as potential biomarkers for cancer diagnosis and therapy. , 2016, American journal of cancer research.

[172]  Chuanxin Wang,et al.  Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development , 2016, Medicine.

[173]  Wei Li,et al.  Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling , 2016, Oncogene.

[174]  M. Dinger,et al.  Endogenous microRNA sponges: evidence and controversy , 2016, Nature Reviews Genetics.

[175]  H. Lynch,et al.  Lynch syndrome in the 21st century: clinical perspectives. , 2016, QJM : monthly journal of the Association of Physicians.

[176]  M. Nagai Pleckstrin homology-like domain, family A, member 1 (PHLDA1) and cancer. , 2016, Biomedical reports.

[177]  Dawood B. Dudekula,et al.  CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs , 2016, RNA biology.

[178]  Igor Ulitsky,et al.  Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor , 2015, Nucleic acids research.

[179]  Xuning Wang,et al.  Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances. , 2015, International journal of clinical and experimental pathology.

[180]  N. Pyrsopoulos,et al.  Hepatocellular carcinoma: A comprehensive review. , 2015, World journal of hepatology.

[181]  M. Ragusa,et al.  Non-coding landscapes of colorectal cancer. , 2015, World journal of gastroenterology.

[182]  Nikolaus Rajewsky,et al.  Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood , 2015, PloS one.

[183]  A. Nebreda,et al.  The Stress Kinase p38α as a Target for Cancer Therapy. , 2015, Cancer research.

[184]  T. Shen,et al.  An intriguing RNA species—perspectives of circularized RNA , 2015, Protein & Cell.

[185]  R. Kanthan,et al.  Gallbladder Cancer in the 21st Century , 2015, Journal of oncology.

[186]  Long Gao,et al.  Runx1 Deficiency Decreases Ribosome Biogenesis and Confers Stress Resistance to Hematopoietic Stem and Progenitor Cells. , 2015, Cell stem cell.

[187]  Haimin Li,et al.  Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma , 2015, Genomics data.

[188]  María José Domper Arnal,et al.  Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries. , 2015, World journal of gastroenterology.

[189]  Zhiyong Guo,et al.  Interaction between microRNA-181a and TNFAIP1 regulates pancreatic cancer proliferation and migration , 2015, Tumor Biology.

[190]  Huajie Cai,et al.  cir-ITCH Plays an Inhibitory Role in Colorectal Cancer by Regulating the Wnt/β-Catenin Pathway , 2015, PloS one.

[191]  Guoxin Zhang,et al.  Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer , 2015, Scientific Reports.

[192]  Petar Glažar,et al.  Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed. , 2015, Molecular cell.

[193]  Xiaoyan Mo,et al.  Using circular RNA as a novel type of biomarker in the screening of gastric cancer. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[194]  Andreas W. Schreiber,et al.  The RNA Binding Protein Quaking Regulates Formation of circRNAs , 2015, Cell.

[195]  Yifeng Zhou,et al.  Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway , 2015, Oncotarget.

[196]  I. Tomlinson,et al.  Clinical management of hereditary colorectal cancer syndromes , 2015, Nature Reviews Gastroenterology &Hepatology.

[197]  B. Jiang,et al.  Low miR-145 expression level is associated with poor pathological differentiation and poor prognosis in non-small cell lung cancer. , 2015, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[198]  R. Zeillinger,et al.  Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues , 2015, Scientific Reports.

[199]  L. Carcas Gastric cancer review , 2014, Journal of carcinogenesis.

[200]  R. Parker,et al.  Circular RNAs: diversity of form and function , 2014, RNA.

[201]  Petar Glažar,et al.  circBase: a database for circular RNAs , 2014, RNA.

[202]  N. Rajewsky,et al.  circRNA biogenesis competes with pre-mRNA splicing. , 2014, Molecular cell.

[203]  E. Westhof,et al.  Biogenesis of Circular RNAs , 2014, Cell.

[204]  Ling-Ling Chen,et al.  Complementary Sequence-Mediated Exon Circularization , 2014, Cell.

[205]  Liang Zhao,et al.  LIM and SH3 Protein 1 Induces TGFβ-Mediated Epithelial–Mesenchymal Transition in Human Colorectal Cancer by Regulating S100A4 Expression , 2014, Clinical Cancer Research.

[206]  Xin Liu,et al.  E-Cadherin and Gastric Cancer: Cause, Consequence, and Applications , 2014, BioMed research international.

[207]  D. Bartel,et al.  Expanded identification and characterization of mammalian circular RNAs , 2014, Genome Biology.

[208]  G. Malaguarnera,et al.  Hepatocellular Carcinoma: Novel Molecular Targets in Carcinogenesis for Future Therapies , 2014, BioMed research international.

[209]  Eva Negri,et al.  Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. , 2014, European journal of cancer.

[210]  N. Sharpless,et al.  Detecting and characterizing circular RNAs , 2014, Nature Biotechnology.

[211]  J. Piriyapongsa,et al.  Identification of a tumor-suppressive human-specific microRNA within the FHIT tumor-suppressor gene. , 2014, Cancer research.

[212]  R. Hundal,et al.  Gallbladder cancer: epidemiology and outcome , 2014, Clinical epidemiology.

[213]  P. Bie,et al.  miR-15a inhibits cell proliferation and epithelial to mesenchymal transition in pancreatic ductal adenocarcinoma by down-regulating Bmi-1 expression. , 2014, Cancer letters.

[214]  F. Ciardiello,et al.  Treatment of gastric cancer. , 2014, World journal of gastroenterology.

[215]  Linfu Xie,et al.  MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1 , 2013, Journal of Translational Medicine.

[216]  M. Zali,et al.  MUTYH the base excision repair gene family member associated with colorectal cancer polyposis , 2013, Gastroenterology and hepatology from bed to bench.

[217]  H. Eguchi,et al.  Involvement of microRNA-181b in the gemcitabine resistance of pancreatic cancer cells. , 2013, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[218]  Julia Salzman,et al.  Cell-Type Specific Features of Circular RNA Expression , 2013, PLoS genetics.

[219]  L. DesGroseillers Faculty Opinions recommendation of Natural RNA circles function as efficient microRNA sponges. , 2013 .

[220]  Yoshiaki Ito,et al.  RUNX family: Regulation and diversification of roles through interacting proteins , 2013, International journal of cancer.

[221]  X. Bian,et al.  MicroRNA-137, an HMGA1 target, suppresses colorectal cancer cell invasion and metastasis in mice by directly targeting FMNL2. , 2013, Gastroenterology.

[222]  Sebastian D. Mackowiak,et al.  Circular RNAs are a large class of animal RNAs with regulatory potency , 2013, Nature.

[223]  J. Pérez-Fidalgo,et al.  Current questions for the treatment of advanced gastric cancer. , 2013, Cancer treatment reviews.

[224]  Michael K. Slevin,et al.  Circular RNAs are abundant, conserved, and associated with ALU repeats. , 2013, RNA.

[225]  Enni Markkanen,et al.  MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNA , 2013, Front. Genet..

[226]  N. Henry,et al.  Cancer biomarkers , 2012, Molecular oncology.

[227]  H A Kestler,et al.  Chitinase enzyme activity in CSF is a powerful biomarker of Alzheimer disease , 2012, Neurology.

[228]  Charles Gawad,et al.  Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types , 2012, PloS one.

[229]  J. Dagorn,et al.  Current Knowledge on Pancreatic Cancer , 2012, Front. Oncol..

[230]  Jørgen Kjems,et al.  miRNA‐dependent gene silencing involving Ago2‐mediated cleavage of a circular antisense RNA , 2011, The EMBO journal.

[231]  R. Hruban,et al.  Pancreatic cancer , 2011, The Lancet.

[232]  M. Selbach,et al.  Global quantification of mammalian gene expression control , 2011, Nature.

[233]  Y. Chung,et al.  A potential oncogenic role of the commonly observed E2F5 overexpression in hepatocellular carcinoma. , 2011, World journal of gastroenterology.

[234]  Yanqing Ding,et al.  FMNL2 Enhances Invasion of Colorectal Carcinoma by Inducing Epithelial-Mesenchymal Transition , 2010, Molecular Cancer Research.

[235]  R. Vibhakar,et al.  Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma , 2008, Journal of Neuro-Oncology.

[236]  W. Lau,et al.  Gallbladder cancer--a comprehensive review. , 2008, The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland.

[237]  Daniel Thomas,et al.  Recognition and Degradation of Myelin Basic Protein Peptides by Serum Autoantibodies: Novel Biomarker for Multiple Sclerosis1 , 2008, The Journal of Immunology.

[238]  S. Steinberg,et al.  BAG-4/SODD and Associated Antiapoptotic Proteins Are Linked to Aggressiveness of Epithelial Ovarian Cancer , 2007, Clinical Cancer Research.

[239]  Ariel Miller,et al.  Serum anti-Glc(α1,4)Glc(α) antibodies as a biomarker for relapsing–remitting multiple sclerosis , 2006, Journal of the Neurological Sciences.

[240]  S. Zeuzem,et al.  Inhibition of RNAse A family enzymes prevents degradation and loss of silencing activity of siRNAs in serum. , 2006, Biochemical pharmacology.

[241]  ジー. アーランダー,マーク,et al.  The identification of tumor , 2005 .

[242]  W. Foulkes,et al.  Germline E-cadherin mutations in hereditary diffuse gastric cancer: assessment of 42 new families and review of genetic screening criteria , 2004, Journal of Medical Genetics.

[243]  R. Mayeux Biomarkers: Potential uses and limitations , 2004, NeuroRX.

[244]  Alison P. Klein,et al.  Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds , 2004, Cancer Research.

[245]  S. Naylor,et al.  Biomarkers: current perspectives and future prospects , 2003, Expert review of molecular diagnostics.

[246]  P. Zaphiropoulos,et al.  Circular RNAs from transcripts of the rat cytochrome P450 2C24 gene: correlation with exon skipping. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[247]  Peter Goodfellow,et al.  Circular transcripts of the testis-determining gene Sry in adult mouse testis , 1993, Cell.

[248]  P. Zaphiropoulos,et al.  Differential expression of cytochrome P450 2C24 transcripts in rat kidney and prostate: evidence indicative of alternative and possibly trans splicing events. , 1993, Biochemical and biophysical research communications.

[249]  C. Cocquerelle,et al.  Mis‐splicing yields circular RNA molecules , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[250]  H Berndt,et al.  [Epidemiology of colorectal cancer]. , 1991, Zeitschrift fur arztliche Fortbildung.

[251]  Kathleen R. Cho,et al.  Scrambled exons , 1991, Cell.

[252]  H. Schellekens,et al.  The hepatitis delta (δ) virus possesses a circular RNA , 1986, Nature.

[253]  H. Domdey,et al.  Nucleotide sequence and secondary structure of potato spindle tuber viroid , 1978, Nature.

[254]  D. Riesner,et al.  Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[255]  Wenze Tian,et al.  Dysregulated circRNAs and ceRNA network in esophageal squamous cell carcinoma. , 2019, Frontiers in bioscience.

[256]  Junming Guo,et al.  Identification of hsa_circ_0005654 as a new early biomarker of gastric cancer. , 2019, Cancer biomarkers : section A of Disease markers.

[257]  Haimin Li,et al.  Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer. , 2019, Epigenomics.

[258]  R. Akhter Circular RNA and Alzheimer's Disease. , 2018, Advances in experimental medicine and biology.

[259]  X Wang,et al.  Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells. , 2018, European review for medical and pharmacological sciences.

[260]  R. Ain,et al.  Regulation of Transcription by Circular RNAs. , 2018, Advances in experimental medicine and biology.

[261]  Ning Zhang,et al.  Circ5379-6, a circular form of tumor suppressor PPARα, participates in the inhibition of hepatocellular carcinoma tumorigenesis and metastasis. , 2018, American journal of translational research.

[262]  Y. Shao,et al.  Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. , 2018, Biomarkers in medicine.

[263]  Junqiang Yan,et al.  Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines. , 2017, American journal of translational research.

[264]  Junming Guo,et al.  Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection , 2017, Journal of Molecular Medicine.

[265]  Liangliang Xu,et al.  The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma , 2016, Journal of Cancer Research and Clinical Oncology.

[266]  Lei Liu,et al.  Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma. , 2016, Cancer biomarkers : section A of Disease markers.

[267]  Feng Li,et al.  The landscape of microRNA, Piwi-interacting RNA, and circular RNA in human saliva. , 2015, Clinical chemistry.

[268]  Kenneth W Witwer,et al.  Circulating microRNA biomarker studies: pitfalls and potential solutions. , 2015, Clinical chemistry.

[269]  E. Kuipers,et al.  Colorectal cancer , 2015, Nature Reviews Disease Primers.

[270]  Mohamad Amin Pourhoseingholi,et al.  Burden of gastrointestinal cancer in Asia; an overview , 2015, Gastroenterology and hepatology from bed to bench.

[271]  Long Cui,et al.  Down-regulation of fecal miR-143 and miR-145 as potential markers for colorectal cancer. , 2012, Saudi medical journal.

[272]  M. Páez de la Cadena,et al.  Identification of hydrophobic proteins as biomarker candidates for colorectal cancer. , 2007, The international journal of biochemistry & cell biology.

[273]  S. Law,et al.  The current management of esophageal cancer. , 2007, Advances in surgery.

[274]  Fearon Er,et al.  The deleted in colorectal cancer (DCC) gene: A candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules , 1995 .

[275]  W. Pierceall,et al.  The deleted in colorectal cancer (DCC) gene: a candidate tumour suppressor gene encoding a cell surface protein with similarity to neural cell adhesion molecules. , 1995, Cancer surveys.

[276]  L. Moreira,et al.  The Application of Clinical Genetics Dovepress the Genetic Basis of Familial Adenomatous Polyposis and Its Implications for Clinical Practice and Risk Management , 2022 .