Targeting of androgen receptor in bone reveals a lack of androgen anabolic action and inhibition of osteogenesis: a model for compartment-specific androgen action in the skeleton.

[1]  J. W. Stallings,et al.  Lifestyle factors and duration of androgen deprivation affect bone mineral density of patients with prostate cancer during first year of therapy. , 2007, Urology.

[2]  Steven M. Tommasini,et al.  Genetic randomization reveals functional relationships among morphologic and tissue-quality traits that contribute to bone strength and fragility , 2007, Mammalian Genome.

[3]  B. Leder.  Gonadal steroids and bone metabolism in men , 2007, Current opinion in endocrinology, diabetes, and obesity.

[4]  E. Seeman,et al.  Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. , 2007, Endocrine reviews.

[5]  Xiao-wei Zhang,et al.  The Effect of Oxandrolone Treatment on Human Osteoblastic Cells , 2007, Journal of burns and wounds.

[6]  S. Boonen,et al.  Impact of Androgens, Growth Hormone, and IGF‐I on Bone and Muscle in Male Mice During Puberty , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[7]  M. Litwin,et al.  Health care cost associated with prostate cancer, androgen deprivation therapy and bone complications. , 2006, The Journal of urology.

[8]  A. Reddi,et al.  Influence of testosterone and dihydrotestosterone on bone-matrix induced endochondral bone formation , 1989, Calcified Tissue International.

[9]  H. Aguila,et al.  The 3.6 kb DNA fragment from the rat Col1a1 gene promoter drives the expression of genes in both osteoblast and osteoclast lineage cells. , 2006, Bone.

[10]  E. Seeman,et al.  Osteocytes—martyrs for integrity of bone strength , 2006, Osteoporosis International.

[11]  K. Wiren,et al.  Osteoblast and osteocyte apoptosis associated with androgen action in bone: requirement of increased Bax/Bcl-2 ratio. , 2006, Bone.

[12]  K. Wiren.  Androgens and bone growth: it's location, location, location. , 2005, Current opinion in pharmacology.

[13]  J. Reeve,et al.  Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  T. Beck,et al.  Varying contributions of growth and ageing to racial and sex differences in femoral neck structure and strength in old age. , 2005, Bone.

[15]  Alen Braut,et al.  Histological Analysis of GFP Expression in Murine Bone , 2005, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[16]  S. Kato,et al.  Androgen receptor null male mice develop late-onset obesity caused by decreased energy expenditure and lipolytic activity but show normal insulin sensitivity with high adiponectin secretion. , 2005, Diabetes.

[17]  P. Bouloux.  Testim 1% testosterone gel for the treatment of male hypogonadism. , 2005, Clinical therapeutics.

[18]  R. Hays,et al.  Effects of testosterone replacement in human immunodeficiency virus-infected women with weight loss. , 2005, The Journal of clinical endocrinology and metabolism.

[19]  Shalender Bhasin,et al.  Older men are as responsive as young men to the anabolic effects of graded doses of testosterone on the skeletal muscle. , 2005, The Journal of clinical endocrinology and metabolism.

[20]  R. Lindsay,et al.  Males Have Larger Skeletal Size and Bone Mass Than Females, Despite Comparable Body Size , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[21]  G. Cunningham,et al.  Andropause: is androgen replacement therapy indicated for the aging male? , 2005, Annual review of medicine.

[22]  M. Holick,et al.  Testosterone increases bone mineral density in female‐to‐male transsexuals: a case series of 15 subjects , 2004, Clinical endocrinology.

[23]  Wei Zheng,et al.  Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment. , 2004, The Journal of clinical endocrinology and metabolism.

[24]  C. Cowell,et al.  The skeletal phenotype of men with previous constitutional delay of puberty. , 2004, The Journal of clinical endocrinology and metabolism.

[25]  S. Boonen,et al.  Role of the Androgen Receptor in Skeletal Homeostasis: The Androgen‐Resistant Testicular Feminized Male Mouse Model , 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  H. Woitge,et al.  Expression and activity of osteoblast-targeted Cre recombinase transgenes in murine skeletal tissues. , 2004, The International journal of developmental biology.

[27]  D. Chinkes,et al.  Effects of long-term oxandrolone administration in severely burned children. , 2004, Surgery.

[28]  K. Jepsen,et al.  Targeted overexpression of androgen receptor in osteoblasts: unexpected complex bone phenotype in growing animals. , 2004, Endocrinology.

[29]  Takahiro Matsumoto,et al.  Function of androgen receptor in gene regulations , 2004, The Journal of Steroid Biochemistry and Molecular Biology.

[30]  Ali Iranmanesh,et al.  Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men. , 2004, The Journal of clinical endocrinology and metabolism.

[31]  K. Tanne,et al.  Effects of Sex Hormone Disturbances on Craniofacial Growth in Newborn Mice , 2004, Journal of dental research.

[32]  K. Wiren,et al.  Androgen inhibition of MAP kinase pathway and Elk-1 activation in proliferating osteoblasts. , 2004, Journal of molecular endocrinology.

[33]  R. Cassens,et al.  Comparison of Ribogreen ® and 18s Rrna Quantitation for Normalizing Real-time Rt-pcr Expression Analysis , 2022 .

[34]  S. Bhasin,et al.  The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. , 2003, The journals of gerontology. Series A, Biological sciences and medical sciences.

[35]  R. Nuti,et al.  Longitudinal association between sex hormone levels, bone loss, and bone turnover in elderly men. , 2003, The Journal of clinical endocrinology and metabolism.

[36]  J. Gustafsson,et al.  Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Xi Jiang,et al.  Dual reporter transgene driven by 2.3Col1a1 promoter is active in differentiated osteoblasts. , 2003, Croatian medical journal.

[38]  Kozo Nakamura,et al.  Suppressive function of androgen receptor in bone resorption , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[39]  Ego Seeman,et al.  The structural and biomechanical basis of the gain and loss of bone strength in women and men. , 2003, Endocrinology and metabolism clinics of North America.

[40]  Bom-taeck Kim,et al.  The Structural and Hormonal Basis of Sex Differences in Peak Appendicular Bone Strength in Rats , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  D. Schoenfeld,et al.  Differential effects of androgens and estrogens on bone turnover in normal men. , 2003, The Journal of clinical endocrinology and metabolism.

[42]  D. Rowe,et al.  Directing the expression of a green fluorescent protein transgene in differentiated osteoblasts: comparison between rat type I collagen and rat osteocalcin promoters. , 2002, Bone.

[43]  K. Wiren,et al.  Osteoblast differentiation influences androgen and estrogen receptor-alpha and -beta expression. , 2002, The Journal of endocrinology.

[44]  U. Sommer,et al.  Concerted Action of Androgens and Mechanical Strain Shifts Bone Metabolism from High Turnover into an Osteoanabolic Mode , 2002, The Journal of experimental medicine.

[45]  S. Yeh,et al.  Generation and characterization of androgen receptor knockout (ARKO) mice: An in vivo model for the study of androgen functions in selective tissues , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Wit,et al.  Gender differences in expression of androgen receptor in tibial growth plate and metaphyseal bone of the rat. , 2002, Bone.

[47]  D. Rowe,et al.  Use of Type I Collagen Green Fluorescent Protein Transgenes to Identify Subpopulations of Cells at Different Stages of the Osteoblast Lineage , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[48]  A. Kenny,et al.  Mechanisms of bone remodeling: implications for clinical practice. , 2002, The Journal of reproductive medicine.

[49]  C. Turner,et al.  Sexual Dimorphism in Vertebral Fragility Is More the Result of Gender Differences in Age‐Related Bone Gain Than Bone Loss , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[50]  D. E. Pennington,et al.  Bone Brittleness Varies with Genetic Background in A/J and C57BL/6J Inbred Mice , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[51]  D. Rowe,et al.  Col1a1‐Driven Transgenic Markers of Osteoblast Lineage Progression , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[52]  K. Chihara,et al.  Testosterone inhibits osteoclast formation stimulated by parathyroid hormone through androgen receptor , 2001, FEBS letters.

[53]  R. Eastell,et al.  Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men. , 2000, The Journal of clinical investigation.

[54]  D. Grobbee,et al.  Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. , 2000, The Journal of clinical endocrinology and metabolism.

[55]  E. Barrett-Connor,et al.  A two-year, double-blind comparison of estrogen-androgen and conjugated estrogens in surgically menopausal women. Effects on bone mineral density, symptoms and lipid profiles. , 1999, The Journal of reproductive medicine.

[56]  S. Arver,et al.  Bone Mineral Density and Androgen Levels in Elderly Males , 1999, Calcified Tissue International.

[57]  B. Riggs,et al.  Androgens regulate bone resorption activity of isolated osteoclasts in vitro. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[58]  S. Khosla,et al.  Effects of gonadal and adrenal androgens in a novel androgen‐responsive human osteoblastic cell line , 1998, Journal of cellular biochemistry.

[59]  O. Johnell,et al.  Assessment of sex hormones and bone mineral density in relation to occurrence of fracture in men: a prospective population-based study. , 1998, Bone.

[60]  J. Compston,et al.  The localization of androgen receptors in human bone. , 1997, The Journal of clinical endocrinology and metabolism.

[61]  S. Schwartz,et al.  Comparison of the effects of estrogen alone and estrogen plus androgen on biochemical markers of bone formation and resorption in postmenopausal women. , 1996, The Journal of clinical endocrinology and metabolism.

[62]  S. Boonen,et al.  Androgens and bone. , 2004, Calcified tissue international.

[63]  M. Tohkin,et al.  Androgens directly stimulate mineralization and increase androgen receptors in human osteoblast-like osteosarcoma cells. , 1994, Biochemical and biophysical research communications.

[64]  T. Arnett,et al.  Interaction of androgen and 1,25‐dihydroxyvitamin D3: Effects on normal rat bone cells , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[65]  B. Komm,et al.  High-affinity androgen binding and androgenic regulation of alpha 1(I)-procollagen and transforming growth factor-beta steady state messenger ribonucleic acid levels in human osteoblast-like osteosarcoma cells. , 1991, Endocrinology.

[66]  L. Demers,et al.  Differential effects of gonadal function on bone histomorphometry in male and female rats , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[67]  M. Drezner,et al.  Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee , 1987, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[68]  N. Otsu.  A threshold selection method from gray level histograms , 1979 .