Experience with clinical testing of dextran solutions.

THE NECESSITY of submitting data to federal agencies in the process of getting approval for marketing led us to conduct studies in medical student volunteers with several batches of dextran solutions. The size of our study—involving 41 healthy young adults in 59 trials—seems to be sufficiently representative to allow some generalization. The observations made in seven cases point to a type of side effect that might be amenable to premedication with an antihistaminic agent. Design of Study. —The quality control of the dextran solutions, as specified in theDefense Medical Purchase Description,1consisted of the following procedure: (1) measurement of the sublingual temperature; (2) determination of the bleeding time (Ivy method); and (3) thrombocyte count, all being done before intravenous infusion of 500 ml of dextran solution (into an antebrachial vein) over a period of 45 to 60 minutes (approximately 10 ml/min), and again immediately after the infusion, half

[1]  R. C. Klein,et al.  Dextran-induced anaphylaxis. , 1967, JAMA.

[2]  Trefor Owen Morgan,et al.  Renal failure associated with low-molecular-weight dextran infusion. , 1966, British medical journal.

[3]  A. Kliman.  Presently useful plasma volume expanders. , 1966, Anesthesiology.

[4]  M. Atik.  Dextrans, their use in surgery and medicine, with emphasis on the low molecular weight fractions. , 1966, Anesthesiology.

[5]  G. B. West,et al.  Reactivity of rats to dextran , 1965, The Journal of pharmacy and pharmacology.

[6]  R. Swank,et al.  Physico-chemical changes in blood arising from dextran infusions. , 1965, Clinical science.

[7]  P. Langsjoen.  Observations in the Excretion of Low Molecular Dextran , 1965, Angiology.

[8]  R. Walton,et al.  ELEVATION OF PLASMA HISTAMINE LEVELS IN THE DOG FOLLOWING ADMINISTRATION OF MUSCLE RELAXANTS, OPIATES AND MACROMOLECULAR POLYMERS. , 1965, The Journal of pharmacology and experimental therapeutics.

[9]  H. Morrelli.  INFECTIOUS DISEASES OF CHILDREN: Third Edition , 1964 .

[10]  E. Hardenbergh,et al.  Anaphylactoid Reaction of the Mouse to Dextran.∗ , 1964, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[11]  L. Vandam,et al.  CASE REPORTAnaphylaxis Associated with the Use of Dextran , 1964 .

[12]  J. H. Getzen,et al.  ANAPHYLACTIC REACTION TO DEXTRAN. A CASE REPORT. , 1963, Archives of internal medicine.

[13]  V. Adamkiewicz,et al.  PASSIVE TRANSFER OF DEXTRAN ANAPHYLACTOID REACTION IN RATS. , 1963, The American journal of physiology.

[14]  G. B. West,et al.  Rats resistant to the dextran anaphylactoid reaction. , 1963, British journal of pharmacology and chemotherapy.

[15]  W. Beraldo,et al.  Inhibitory effects of carbohydrates on histamine release and mast cell disruption by dextran. , 1962, British journal of pharmacology and chemotherapy.

[16]  L. Adamkiewicz,et al.  Glucose and the dextran 'anaphylactoid' inflammation. , 1960, The American journal of physiology.

[17]  E. Kabat,et al.  The effect of variation in molecular weight on the antigenicity of dextran in man. , 1958, Archives of biochemistry and biophysics.

[18]  G. B. West,et al.  5‐Hydroxytryptamine and the anaphylactoid reaction in the rat , 1957, The Journal of physiology.

[19]  E. Kabat,et al.  Studies on the immunochemical basis of allergic reactions to dextran in man. , 1957, The Journal of clinical investigation.

[20]  W. Paton.  Histamine release by compounds of simple chemical structure. , 1957, Pharmacological reviews.

[21]  J. Squire.  DextranIts Properties and Use in Medicine , 1956 .

[22]  C. Haining.  Histamine release in rabbit blood by dextran and dextran sulphate. , 1955, British journal of pharmacology and chemotherapy.

[23]  M. R. Silva.  Histamine : its role in anaphylaxis and allergy , 1955 .

[24]  Pulaski Ej.  The clinical status of dextran, PVP and gelatin products. , 1952 .

[25]  Bloom Wl,et al.  The effects of antihistaminic agents on the reaction of the rat to dextran. , 1951 .

[26]  A. Voorhees,et al.  Reactions of Albino Rats to Injections of Dextran , 1951, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[27]  R. Macmillan,et al.  The anti-histamine properties of benadryl, beta-di-methylaminoethyl benzhydryl ether hydrochloride. , 1946, The Journal of pharmacology and experimental therapeutics.