Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data
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Seda Genc | Isil Aksan Kurnaz | Mustafa Ozilgen | I. Kurnaz | S. Genc | M. Ozilgen | Mustafa Özilgen
[1] A. Halestrap,et al. The Plasma Membrane Lactate Transporter MCT4, but Not MCT1, Is Up-regulated by Hypoxia through a HIF-1α-dependent Mechanism* , 2006, Journal of Biological Chemistry.
[2] S. Moncada,et al. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1 , 2009, Nature Cell Biology.
[3] Aleksander S Popel,et al. A computational model of intracellular oxygen sensing by hypoxia-inducible factor HIF1α , 2006, Journal of Cell Science.
[4] P. Canioni,et al. Glucose and Lactate Metabolism in C6 Glioma Cells: Evidence for the Preferential Utilization of Lactate for Cell Oxidative Metabolism , 1998, Developmental Neuroscience.
[5] D. Rossi,et al. Astrocyte metabolism and signaling during brain ischemia , 2007, Nature Neuroscience.
[6] Albert Gjedde,et al. Oxidative and Nonoxidative Metabolism of Excited Neurons and Astrocytes , 2002, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[7] G. Semenza. Hypoxia-Inducible Factor 1: Control of Oxygen Homeostasis in Health and Disease , 2001, Pediatric Research.
[8] Allan I. Pack,et al. The energy hypothesis of sleep revisited , 2008, Progress in Neurobiology.
[9] Peter Lipton,et al. Do active cerebral neurons really use lactate rather than glucose? , 2001, Trends in Neurosciences.
[10] K. Oyanagi,et al. Degeneration of Astrocytic Processes and Their Mitochondria in Cerebral Cortical Regions Peripheral to the Cortical Infarction: Heterogeneity of Their Disintegration Is Closely Associated With Disseminated Selective Neuronal Necrosis and Maturation of Injury , 2009, Stroke.
[11] I. Kurnaz,et al. An in silico model for HIF‐α regulation and hypoxia response in tumor cells , 2007 .
[12] L. Sokoloff,et al. Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[13] O. Porras,et al. Glutamate Triggers Rapid Glucose Transport Stimulation in Astrocytes as Evidenced by Real-Time Confocal Microscopy , 2003, The Journal of Neuroscience.
[14] R G Shulman,et al. Energy on Demand , 1999, Science.
[15] Shaoqun Zeng,et al. Dynamic analysis of optimality in myocardial energy metabolism under normal and ischemic conditions , 2006, Molecular systems biology.
[16] Á. Almeida,et al. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture , 2002, Journal of neurochemistry.
[17] L. Gladden. Lactate metabolism: a new paradigm for the third millennium , 2004, The Journal of physiology.
[18] 김삼묘,et al. “Bioinformatics” 특집을 내면서 , 2000 .
[19] P. Magistretti,et al. Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging. , 1999, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
[20] Lufang Zhou,et al. Mechanistic model of cardiac energy metabolism predicts localization of glycolysis to cytosolic subdomain during ischemia. , 2005, American journal of physiology. Heart and circulatory physiology.
[21] T. Esmaeilpour,et al. Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. , 2006, Reproduction.
[22] Neil Swainston,et al. Towards a genome-scale kinetic model of cellular metabolism , 2010, BMC Systems Biology.
[23] K. Jungermann,et al. Cross-talk between the signals hypoxia and glucose at the glucose response element of the L-type pyruvate kinase gene. , 2001, Endocrinology.
[24] M. L. Kurnaz,et al. Cytoplasmic‐to‐nuclear volume ratio affects AP‐1 complex formation as an indicator of cell cycle responsiveness , 2005, FEBS letters.
[25] P. Magistretti,et al. Activity‐dependent regulation of energy metabolism by astrocytes: An update , 2007, Glia.
[26] Silvia Mangia,et al. The in vivo neuron‐to‐astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation , 2009, Journal of neurochemistry.
[27] D. Kaufer,et al. Evidence for the Mitochondrial Lactate Oxidation Complex in Rat Neurons: Demonstration of an Essential Component of Brain Lactate Shuttles , 2008, PloS one.
[28] G. Dienel,et al. Glucose and lactate metabolism during brain activation , 2001, Journal of neuroscience research.
[29] A. Aubert,et al. Interaction between Astrocytes and Neurons Studied using a Mathematical Model of Compartmentalized Energy Metabolism , 2005, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[30] Jan W. P. Kuiper,et al. Creatine kinase B deficient neurons exhibit an increased fraction of motile mitochondria , 2008, BMC Neuroscience.
[31] N. Price,et al. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. , 1999, The Biochemical journal.
[32] E. Gilles,et al. Modeling the electron transport chain of purple non-sulfur bacteria , 2008, Molecular systems biology.
[33] J. Martiel,et al. A glia–neuron alanine/ammonium shuttle is central to energy metabolism in bee retina , 2008, The Journal of physiology.
[34] Pierre J Magistretti,et al. Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[35] I. S. Wood,et al. Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes , 2010, Pflügers Archiv - European Journal of Physiology.
[36] Mudita Singhal,et al. COPASI - a COmplex PAthway SImulator , 2006, Bioinform..