Use of metabolically competent human hepatoma cells for the detection of mutagens and antimutagens.
暂无分享,去创建一个
G Williamson | R Sanyal | F Darroudi | T. Langer | A. Natarajan | G. Williamson | V. Mersch-Sundermann | F. Darroudi | S. Knasmüller | W. Parzefall | R. Sanyal | W Parzefall | S Knasmüller | V Mersch-Sundermann | A T Natarajan | S. Ecker | C. Schwab | M. Uhl | G. Hietsch | T Langer | M Uhl | S Ecker | C Schwab | G Hietsch | V. Mersch‐Sundermann | Theo Langer | Sonja Ecker
[1] R Sanyal,et al. Inhibition of the genotoxic effects of heterocyclic amines in human derived hepatoma cells by dietary bioantimutagens. , 1997, Mutagenesis.
[2] V. Mersch-Sundermann,et al. Nitro musks are cogenotoxicants by inducing toxifying enzymes in the rat. , 1996, Mutation research.
[3] A. Natarajan,et al. Detection of aneugenic and clastogenic potential of X-rays, directly and indirectly acting chemicals in human hepatoma (Hep G2) and peripheral blood lymphocytes, using the micronucleus assay and fluorescent in situ hybridization with a DNA centromeric probe. , 1996, Mutagenesis.
[4] H. Glatt,et al. Development and validation of alternative metabolic systems for mutagenicity testing in short-term assays. , 1996, Mutation research.
[5] V. Mersch-Sundermann,et al. A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity. , 1996, Toxicology letters.
[6] E. Davie,et al. Transcriptional Regulation of the Gene Coding for Human Protein C (*) , 1996, The Journal of Biological Chemistry.
[7] R. Ulrich,et al. Identification of dioxin-responsive genes in Hep G2 cells using differential mRNA display RT-PCR. , 1996, Biochemical and biophysical research communications.
[8] R Sanyal,et al. Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4, 5-beta]pyridine (PhIP). , 1996, Mutation research.
[9] H. Nakajima,et al. Enzymic sulphation of dopa and tyrosine isomers by HepG2 human hepatoma cells: stereoselectivity and stimulation by Mn2+. , 1996, The Biochemical journal.
[10] L. Bingle,et al. Characterization of the human surfactant protein D promoter: transcriptional regulation of SP-D gene expression by glucocorticoids. , 1996, American journal of respiratory cell and molecular biology.
[11] C. Rompelberg,et al. Effect of eugenol on the genotoxicity of established mutagens in the liver. , 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
[12] P. Kasper,et al. Evaluation studies on the in vitro rat hepatocyte micronucleus assay. , 1995, Mutation research.
[13] P. Dierickx,et al. Mutagenic activation of aromatic amines by a human hepatoma cell (Hep G2) supernatant tested by means of Salmonella typhimurium strains with different acetyltransferase activities. , 1995, Mutation research.
[14] A. Cederbaum,et al. Increased Cytotoxicity of 3-Morpholinosydnonimine to HepG2 Cells in the Presence of Superoxide Dismutase , 1995, The Journal of Biological Chemistry.
[15] S. Babajko. Transcriptional regulation of insulin-like growth factor binding protein-1 expression by insulin and cyclic AMP. , 1995, Growth regulation.
[16] K. Adeli,et al. Human bioassays to assess environmental genotoxicity: Development of a DNA break bioassay in HepG2 cells☆ , 1995 .
[17] S. Michel,et al. Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. , 1995, Carcinogenesis.
[18] K. Adeli,et al. Human bioassays to assess environmental genotoxicity: development of a DNA break bioassay in HepG2 cells. , 1994, Clinical biochemistry.
[19] G. Koren,et al. Acetaminophen-induced toxicity to human epidermoid cell line A431 and hepatoblastoma cell line Hep G2, in vitro, is diminished by silymarin. , 1995, Skin pharmacology : the official journal of the Skin Pharmacology Society.
[20] H. Glatt,et al. Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells. , 1994, Mutation research.
[21] M. Liu,et al. De novo sulfation of L-tyrosine in HepG2 human hepatoma cells and its possible functional implication. , 1994, European journal of biochemistry.
[22] A. Natarajan,et al. Induction of Sister-chromatid Exchanges, Micronuclei and Gene Mutations by Indirectly Acting Promutagens Using Human Hepatoma Cells as an Activation System , 1994 .
[23] H. Rosenkranz,et al. Pathways for the mutagenesis of 1-nitropyrene and dinitropyrenes in the human hepatoma cell line HepG2. , 1994, Environmental health perspectives.
[24] T. Deguchi,et al. Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. , 1994, Cancer research.
[25] T. Walle,et al. Human phenolsulfotransferases: chiral substrates and expression in Hep G2 cells , 1994 .
[26] L. Ferguson. Antimutagens as cancer chemopreventive agents in the diet. , 1994, Mutation research.
[27] C. Takahashi,et al. Cytogenetic effects of the antichagasic benznidazole on human cells in vitro. , 1994, Mutation research.
[28] R. Schulte‐Hermann,et al. Effects of ethanol treatment on DNA damage induced in Escherichia coli K-12 in various organs of mice by N-nitro-sonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosopyrrolidine. , 1994, Carcinogenesis.
[29] G Koren,et al. In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line. , 1993, Biochemical and biophysical research communications.
[30] A. Natarajan,et al. The anticlastogenicity of β-carotene evaluated on human hepatoma cells , 1993 .
[31] P. Dierickx,et al. Metabolic activation by a supernatant from human hepatoma cells: a possible alternative in mutagenic tests. , 1993, Mutation research.
[32] E. Sim,et al. Arylamine N-acetyltransferase activity in human cultured cell lines. , 1993, The Biochemical journal.
[33] C. Wolf,et al. The effects of inducing agents on cytochrome P450 and UDP-glucuronyltransferase activities in human HEPG2 hepatoma cells. , 1993, Biochemical pharmacology.
[34] R. -. Streeck,et al. Mutational analysis of the cysteine residues in the hepatitis B virus small envelope protein , 1993, Journal of virology.
[35] L. Poellinger,et al. Dioxin receptor and C/EBP regulate the function of the glutathione S-transferase Ya gene xenobiotic response element , 1993, Molecular and cellular biology.
[36] A. Pfeifer,et al. Simian virus 40 large tumor antigen-immortalized normal human liver epithelial cells express hepatocyte characteristics and metabolize chemical carcinogens. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[37] R. Burk,et al. Characterization of the role of individual protein binding motifs within the hepatitis B virus enhancer I on X promoter activity using linker scanning mutagenesis. , 1993, Virology.
[38] Tsung-Yun Liu,et al. Differential sensitivity of human hepatoma cell line and primary rat hepatocyte culture to benzo(a)pyrene‐induced unscheduled DNA synthesis and adduct formation. , 1993, Cell biology international.
[39] D. Casciano,et al. HepG2 cells: an in vitro model for P450-dependent metabolism of acetaminophen. , 1993, Biochemical and biophysical research communications.
[40] T. Ohta. Modification of genotoxicity by naturally occurring flavorings and their derivatives. , 1993, Critical reviews in toxicology.
[41] A. Natarajan,et al. Metabolic activation of chemicals to mutagenic carcinogens by human hepatoma microsomal extracts in Chinese hamster ovary cells (in vitro). , 1993, Mutagenesis.
[42] D. Kardassis,et al. Organization of the regulatory elements and nuclear activities participating in the transcription of the human apolipoprotein B gene. , 1992, The Journal of biological chemistry.
[43] E. Roscher,et al. Genotoxicity of 1,3- and 1,6-dinitropyrene: induction of micronuclei in a panel of mammalian test cell lines. , 1992, Mutation research.
[44] R. Weichselbaum,et al. Protection against AZT-induced mutagenesis at the HGPRT locus in a human cell line by WR-151326. , 1992, International journal of radiation oncology, biology, physics.
[45] A. Natarajan,et al. Use of human hepatoma cells for in vitro metabolic activation of chemical mutagens/carcinogens. , 1991, Mutagenesis.
[46] S. Singh,et al. Effect of diallyl sulfide, a naturally occurring anti-carcinogen, on glutathione-dependent detoxification enzymes of female CD-1 mouse tissues. , 1991, Biochemical pharmacology.
[47] H. Wu,et al. Characterization and genetic analysis of alternatively spliced transcripts of hepatitis B virus in infected human liver tissues and transfected HepG2 cells , 1991, Journal of virology.
[48] N. Loprieno,et al. An experimental approach to identifying the genotoxic risk by cooked meat mutagens. , 1991, Advances in experimental medicine and biology.
[49] M. Bauchinger,et al. Induction of chromosome aberrations and sister chromatid exchange by indirectly acting mutagens in immortal mouse and rat hepatocyte lines. , 1991, Mutagenesis.
[50] R. Pecce,et al. Effect of enzyme inducers on metabolism of 1-nitropyrene in human hepatoma cell line HepG2. , 1991, Chemico-biological interactions.
[51] M Ishidate,et al. Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels. , 1990, Mutation research.
[52] A. Martelli,et al. Human hepatocytes in genotoxicity assays. , 1990, Pharmacological research.
[53] H. Glatt,et al. Stable expression of rat cytochrome P-450IA1 cDNA in V79 Chinese hamster cells and their use in mutagenicity testing. , 1990, Molecular pharmacology.
[54] O. Mcbride,et al. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. , 1990, Biochemistry.
[55] A. Carrano,et al. In vivo cytogenetic effects of cooked food mutagens. , 1989, Mutation research.
[56] P. Labruzzo,et al. Induction of aryl hydrocarbon hydroxylase and demonstration of a specific nuclear receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin in two human hepatoma cell lines. , 1989, Biochemical pharmacology.
[57] A. Bensimon,et al. Regulatory elements controlling the basal and drug-inducible expression of glutathione S-transferase Ya subunit gene. , 1989, DNA.
[58] G. Bárány,et al. Inhibition of N-nitrosodiethylamine carcinogenesis in mice by naturally occurring organosulfur compounds and monoterpenes. , 1989, Cancer research.
[59] B E Butterworth,et al. Use of primary cultures of human hepatocytes in toxicology studies. , 1989, Cancer research.
[60] M. Grant,et al. The influence of culture medium composition on drug metabolising enzyme activities of the human liver derived Hep G2 cell line , 1988, FEBS letters.
[61] S. De Flora,et al. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview. , 1988, Mutation research.
[62] M. Grant,et al. Mixed function oxidase and UDP-glucuronyltransferase activities in the human Hep G2 hepatoma cell line. , 1988, Biochemical pharmacology.
[63] M. Grant,et al. Status of reduced glutathione in the human hepatoma cell line, HEP G2. , 1988, Biochemical pharmacology.
[64] E. Roscher,et al. Mutagenicity, clastogenicity and cytotoxicity of procarcinogens in a rat hepatoma cell line competent for xenobiotic metabolism. , 1988, Mutagenesis.
[65] J. C. Ball,et al. A preliminary study of an iron porphyrin-iodosylbenzene system for activation of mutagens in the Ames assay. , 1988, Mutation research.
[66] R. Meschini,et al. Induction of sister-chromatid exchanges by procarcinogens in metabolically competent Chinese hamster epithelial liver cells. , 1988, Mutation research.
[67] G. Bárány,et al. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. , 1988, Carcinogenesis.
[68] G. Michalopoulos,et al. Induction of sister chromatid exchanges in cultured adult rat hepatocytes by directly and indirectly acting mutagens/carcinogens. , 1987, Carcinogenesis.
[69] H. Rosenkranz,et al. Mutagenicity, unscheduled DNA synthesis, and metabolism of 1-nitropyrene in the human hepatoma cell line HepG2. , 1987, Cancer research.
[70] B H Margolin,et al. Prediction of chemical carcinogenicity in rodents from in vitro genetic toxicity assays. , 1987, Science.
[71] H. Glatt,et al. Rat hepatocyte-mediated bacterial mutagenicity in relation to the carcinogenic potency of benz(a)anthracene, benzo(a)pyrene, and twenty-five methylated derivatives. , 1987, Cancer research.
[72] O. Sugita,et al. Drug metabolism by the human hepatoma cell, Hep G2. , 1987, Biochemical and biophysical research communications.
[73] D. Casciano,et al. Use of the human liver cell line Hep G2 in a modified Salmonella reversion assay. , 1986, Cancer letters.
[74] J. Williams,et al. Induction of sister chromatid exchanges in human and rat hepatoma cell lines by cyclophosphamide and phosphoramide mustard and the effects of cytochrome P-450 inhibitors. , 1986, Biochemical pharmacology.
[75] N. Ikekawa,et al. Detection of natural bio-antimutagens and in vivo and in vitro analysis of their action. , 1986, Progress in clinical and biological research.
[76] E. Gocke,et al. Differential mutagenic activity of IQ (2-amino-3-methylimidazo[4,5-f]quinoline) in Salmonella typhimurium strains in vitro and in vivo, in Drosophila, and in mice. , 1985, Mutation research.
[77] J. DiGiovanni,et al. Comparison of the metabolic activation of 7, 12-dimethylbenz(a)anthracene by a human hepatoma cell line (HepG2) and low passage hamster embryo cells. , 1984, Cancer research.
[78] J. DiGiovanni,et al. Mutagenic activity of methyl- and fluoro-substituted derivatives of polycyclic aromatic hydrocarbons in a human hepatoma (HepG2) cell-mediated assay. , 1984, Mutation research.
[79] G. Williams,et al. Differences in responses of 4 adult rat-liver epithelial cell lines to a spectrum of chemical mutagens. , 1984, Mutation research.
[80] K. Lindahl-Kiessling,et al. Frequency of sister chromatid exchanges in human lymphocytes cultivated with a human hepatoma cell line as an indicator of the carcinogenic potency of two cyclopenta[a]phenanthrenes. , 1984, Carcinogenesis.
[81] R. Bos,et al. Mutagenicity testing with the Salmonella/hepatocyte and the Salmonella/microsome assays. A comparative study with some known genotoxic compounds. , 1983, Mutation research.
[82] R. Dean,et al. Activation of polycyclic hydrocarbons in Reuber H4-II-E hepatoma cells. An in vitro system for the induction of SCEs. , 1983, Mutation research.
[83] S. Limbosch. Benzo[a]pyrene- and aldrin-metabolizing activities in cultured human and rat hepatoma cell lines. , 1983, Journal of the National Cancer Institute.
[84] B. Ames,et al. Revised methods for the Salmonella mutagenicity test. , 1983, Mutation research.
[85] J. Williams,et al. Evaluation of a human hepatoma cell line as a target cell in genetic toxicology. , 1983, Mutation research.
[86] J. DiGiovanni,et al. Mutagenesis in Chinese hamster cells by cyclopenta(a)phenanthrenes activated by a human hepatoma cell line. , 1983, Cancer research.
[87] J. R. McLain,et al. Isolation, culture, and transplantation of human hepatocytes. , 1982, Journal of the National Cancer Institute.
[88] L. Wattenberg,et al. Glutathione S-transferase activity: enhancement by compounds inhibiting chemical carcinogenesis and by dietary constituents. , 1982, Journal of the National Cancer Institute.
[89] G. Williams,et al. Sister-chromatid exchange induction by polycyclic aromatic hydrocarbons in an intact cell system of adult rat-liver epithelial cells. , 1981, Mutation research.
[90] M. Lipkin,et al. Inhibition of Tumor Induction and Development , 1981 .
[91] L. Wattenberg,et al. Inhibition of Chemical Carcinogenesis by Phenols, Coumarins, Aromatic Isothiocyanates, Flavones, and Indoles , 1981 .
[92] E. Schneider,et al. Sister-chromatid exchange induction by carcinogens in HTC cells: an in vitro system which does not require addition of activating factors. , 1980, Mutation research.
[93] W. Baird,et al. Metabolic activation of benzo[a]pyrene by a human hepatoma cell line. , 1980, Carcinogenesis.
[94] A. Dipple,et al. Limitations of metabolic activation systems used with in vitro tests for carcinogens. , 1980, Science.
[95] C C Howe,et al. Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. , 1980, Science.
[96] L. Sultatos,et al. Enhanced drug-metabolizing capacity within liver adjacent to human and rat liver tumors. , 1980, Proceedings of the National Academy of Sciences of the United States of America.
[97] Ivan Damjanov,et al. Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line , 1979, Nature.
[98] J. Selkirk. Divergence of metabolic activation systems for short-term mutagenesis assays , 1977, Nature.
[99] T. Sugimura,et al. Mutagenicities of N-nitrosamines on Salmonella. , 1977, Mutation research.
[100] G. Ficsor,et al. Mammalian host- and fluid-mediated mutagenicity assays of captan and streptozotocin in Salmonella typhimurium. , 1977, Mutation research.
[101] E. Farber,et al. A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. , 1976, Cancer research.
[102] G. Michalopoulos,et al. Maintenance of microsomal cytochromes b5 and P-450 in primary cultures of parenchymal liver cells on collagen membranes. , 1976, Life sciences.
[103] W B Jakoby,et al. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. , 1974, The Journal of biological chemistry.
[104] E. Gebhart. Antimutagens. Data and problems. , 1974, Humangenetik.