论文信息 - Caspase-2 and the oxidative stress response

Caspase-2 and the oxidative stress response

Caspase-2, one of the earliest discovered caspases, has emerged as a multifunctional enzyme with roles that are not limited to cell death. It acts as a tumor suppressor, prevents genetic instability, and protects against aging by playing a crucial role in sensing alterations in cellular redox status and activating the antioxidant defense system. These apparent non-apoptotic functions, only discovered recently, emphasize the importance of this often-neglected protease.

Sharad Kumar | S. Shalini

[1] Sharad Kumar,et al. Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice , 2015, Cell Death and Disease.

[2] Sharad Kumar,et al. Caspase-2 protects against oxidative stress in vivo , 2014, Oncogene.

[3] Sharad Kumar,et al. Old, new and emerging functions of caspases , 2014, Cell Death and Differentiation.

[4] Sharad Kumar,et al. Caspase-2 as a tumour suppressor , 2013, Cell Death and Differentiation.

[5] B. Herman,et al. Loss of caspase-2 accelerates age-dependent alterations in mitochondrial production of reactive oxygen species , 2013, Biogerontology.

[6] S. Kumar,et al. Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability , 2012, Cell Death and Differentiation.

[7] S. Kumar,et al. Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice , 2012, Cell Death and Differentiation.

[8] Sharad Kumar. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more? , 2009, Nature Reviews Cancer.

[9] Arlan Richardson,et al. Caspase-2 deficiency enhances aging-related traits in mice , 2007, Mechanisms of Ageing and Development.

[10] N. Copeland,et al. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. , 1994, Genes & development.