Photonic Sensing of Electrophysiological Activity for Wearable Applications

Photonic biosensors, featuring small size, lightweight, and remote sensing ability through optical fibers, show huge potential for wearable bioelectric applications. Electro-optic (EO) devices have high-input impedance and can achieve small-driving voltages, just what is required for a sensor targeting bioelectric activity monitoring. This paper proposes a multi-parameter bioelectric acquisition platform with a photonic sensor based on EO methods, and electronic circuitry for signal conditioning, filtering and amplification. The core sensing technology is based on a Lithium Niobate Mach-Zehnder interferometer modulator, which responds to the bioelectric signal by modulating the input light intensity. The photonic sensor performance was compared with standard acquisition systems. Results have shown that the developed sensor is reliable and allows multi-parameter acquisition with acceptable gain (from 1 to 4 mV/μV), sensitivity (minimum detected field of 20 μV), frequency content, and clinical relevance.

[1]  E.L. Wooten,et al.  A review of lithium niobate modulators for fiber-optic communications systems , 2000, IEEE Journal of Selected Topics in Quantum Electronics.

[2]  Ai-ichiro Sasaki,et al.  Study of semiconductor electro-optic modulators for sensing extremely-low-frequency electrical signals , 2009 .

[3]  P. M. Mendes,et al.  Flexible PDMS -based dry electrodes for electro-optic acquisition of ECG signals in wearable devices , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[4]  M. Velasco-Garcia,et al.  Optical biosensors for probing at the cellular level: a review of recent progress and future prospects. , 2009, Seminars in cell & developmental biology.

[5]  Guo-Qiang Lo,et al.  Highly sensitive Mach–Zehnder interferometer biosensor based on silicon nitride slot waveguide , 2013 .

[6]  Marco Tartagni,et al.  Noise Limits of CMOS Current Interfaces for Biosensors: A Review , 2014, IEEE Transactions on Biomedical Circuits and Systems.

[7]  Yuze Sun,et al.  Sensitive optical biosensors for unlabeled targets: a review. , 2008, Analytica chimica acta.

[8]  Panayiotis A. Kyriacou,et al.  Investigation of new electro optical techniques for monitoring patients with compromised peripheral perfusion in anaesthesia. , 2001 .

[9]  B. Culshaw Fiber optics in sensing and measurement , 2000, IEEE Journal of Selected Topics in Quantum Electronics.

[10]  Hugo Hoekstra,et al.  Noise and resolution in IO interferometric sensing , 2007 .

[11]  P. Shankar,et al.  A review of fiber-optic biosensors , 2007 .

[12]  A. MacDiarmid,et al.  Fiber Optic Sensors and Smart Fabrics , 2000 .

[13]  Stuart A. Kingsley,et al.  Photrodes for physiological sensing , 2004, SPIE BiOS.

[14]  Clay K. Kirkendall,et al.  Overview of high performance fibre-optic sensing , 2004 .

[15]  Michael Norris,et al.  Design and development of medical electronic instrumentation : a practical perspective of the design, construction, and test of medical devices , 2004 .

[16]  Mahmoud El-Sherif Smart fabrics: integrating fiber optic sensors and information networks. , 2004, Studies in health technology and informatics.

[17]  Maria Morant,et al.  Dual-drive LiNbO3 interferometric Mach-Zehnder architecture with extended linear regime for high peak-to-average OFDM-based communication systems. , 2011, Optics express.

[18]  Stuart A. Kingsley,et al.  Revolutionary optical sensor for physiological monitoring in the battlefield , 2004, SPIE Defense + Commercial Sensing.

[19]  Ai-ichiro Sasaki,et al.  Principle and Application of a Sensitive Handy Electrooptic Probe for Sub-100-MHz Frequency Range Signal Measurements , 2008, IEEE Transactions on Instrumentation and Measurement.

[20]  M. Morse,et al.  High speed silicon Mach-Zehnder modulator. , 2005, Optics express.

[21]  Mounir Boukadoum,et al.  A dual-mode, low-power and low-noise 0.18µm CMOS front-end for optical biosensors , 2012, 2012 IEEE International Symposium on Circuits and Systems.

[22]  A. Walker Electroencephalography, Basic Principles, Clinical Applications and Related Fields , 1982 .

[23]  A. Bakar,et al.  Electrocardiographic signal detection using self-mixing interferometer technique with customized electro-optic phase modulator , 2012, 2012 IEEE 3rd International Conference on Photonics.

[24]  Paulo Mateus Mendes,et al.  A Smart Skin PVC Foil Based on FBG Sensors for Monitoring Strain and Temperature , 2011, IEEE Transactions on Industrial Electronics.

[25]  Dan Wu,et al.  Graphene-Based Optical and Electrochemical Biosensors: A Review , 2013 .

[26]  John Michael Wyrwas Linear, Low Noise Microwave Photonic Systems using Phase and Frequency Modulation , 2012 .

[27]  S. Jha,et al.  Optical biosensors for food quality and safety assurance—a review , 2012, Journal of Food Science and Technology.

[28]  Dimitrios I. Fotiadis,et al.  Wearable Devices in Healthcare , 2005 .

[29]  Luís Bica Oliveira,et al.  Noise Performance of a Regulated Cascode Transimpedance Amplifier for Radiation Detectors , 2012, IEEE Transactions on Circuits and Systems I: Regular Papers.

[30]  Wei Chen,et al.  Electrically conductive yarns based on PVA/carbon nanotubes , 2007 .

[31]  Jerald Graeme,et al.  Photodiode Amplifiers: OP AMP Solutions , 1995 .

[32]  Joel Santos-Aguilar,et al.  An all-fibre and integrated optics electric field sensing scheme using matched optical delays and coherence modulation of light , 2007 .

[33]  J. Cram,et al.  Introduction to Surface Electromyography , 1998 .

[34]  V. K. Murthy,et al.  Clinical Usefulness Of ECG Frequency Spectrum Analysis , 1978 .

[35]  S. B. Qadri,et al.  Optimal electro-optic sensor configuration for phase noise limited, remote field sensing applications , 2009 .

[36]  José Higino Correia,et al.  PVC formulation study for the manufacturing of a skin smart structure based in optical fiber elements , 2012 .

[37]  Seulki Lee,et al.  A Wearable ECG Acquisition System With Compact Planar-Fashionable Circuit Board-Based Shirt , 2009, IEEE Transactions on Information Technology in Biomedicine.

[38]  Frank Bucholtz,et al.  Ultra-low-drift, sub-microvolt low-frequency fiber optic voltage sensor , 1994, Other Conferences.

[39]  Rita Paradiso,et al.  A wearable health care system based on knitted integrated sensors , 2005, IEEE Transactions on Information Technology in Biomedicine.

[40]  Vittorio M. N. Passaro,et al.  Recent Advances in Integrated Photonic Sensors , 2012, Sensors.

[41]  J. Webster Encyclopedia of Medical Devices and Instrumentation , 1988 .

[42]  Bozena Kaminska,et al.  Mechanically Flexible Wireless Multisensor Platform for Human Physical Activity and Vitals Monitoring , 2010, IEEE Transactions on Biomedical Circuits and Systems.

[43]  M. El-Sherif 6 – Integration of fibre optic sensors and sensing networks into textile structures , 2005 .