Fruit Flies in Biomedical Research
暂无分享,去创建一个
Michael F. Wangler | Hugo J Bellen | H. Bellen | Shinya Yamamoto | M. Wangler | Shinya Yamamoto | Michael F Wangler | Shinya Yamamoto
[1] Robert L Moritz,et al. Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins , 2000, Cell.
[2] P. Shannon,et al. Exome sequencing identifies the cause of a Mendelian disorder , 2009, Nature Genetics.
[3] P. Hiesinger,et al. Mapping Drosophila mutations with molecularly defined P element insertions , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[4] J. Abrams. An emerging blueprint for apoptosis in Drosophila. , 1999, Trends in cell biology.
[5] T. Tully,et al. Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene , 1992, Neuron.
[6] Chris P. Ponting,et al. Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System , 2013, Cell reports.
[7] Jim Thurmond,et al. FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations , 2014, Nucleic Acids Res..
[8] Laura Ponting,et al. FlyBase 102—advanced approaches to interrogating FlyBase , 2013, Nucleic Acids Res..
[9] Magalie S Leduc,et al. Clinical whole-exome sequencing for the diagnosis of mendelian disorders. , 2013, The New England journal of medicine.
[10] Benedict M. Sattelle,et al. Ion channels: molecular targets of neuroactive insecticides , 2005, Invertebrate Neuroscience.
[11] E. Popodi,et al. A Molecularly Defined Duplication Set for the X Chromosome of Drosophila melanogaster , 2010, Genetics.
[12] Josefa González,et al. A Transposable Element Insertion Confers Xenobiotic Resistance in Drosophila , 2014, PLoS genetics.
[13] E. Lewis. A gene complex controlling segmentation in Drosophila , 1978, Nature.
[14] J. C. Clemens,et al. Drosophila Dscam Is an Axon Guidance Receptor Exhibiting Extraordinary Molecular Diversity , 2000, Cell.
[15] Jun Wang,et al. Identification and characterization of insect-specific proteins by genome data analysis , 2007, BMC Genomics.
[16] R J Konopka,et al. Clock mutants of Drosophila melanogaster. , 1971, Proceedings of the National Academy of Sciences of the United States of America.
[17] Xiaodong Wang,et al. Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition , 2000, Cell.
[18] Michael J. Lush,et al. HCOP: a searchable database of human orthology predictions , 2006, Briefings Bioinform..
[19] R. Drysdale,et al. A distinct potassium channel polypeptide encoded by the Drosophila eag locus , 1991, Science.
[20] M Hertig,et al. Studies on Rickettsia-Like Micro-Organisms in Insects. , 1924, The Journal of medical research.
[21] Hao Wang,et al. A Mutation in EGF Repeat-8 of Notch Discriminates Between Serrate/Jagged and Delta Family Ligands , 2012, Science.
[22] D. Poulson. Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster. , 1937, Proceedings of the National Academy of Sciences of the United States of America.
[23] B. Barrell,et al. From first base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. , 2001, Genome research.
[24] P. Stankiewicz,et al. The genomic basis of disease, mechanisms and assays for genomic disorders. , 2006, Genome dynamics.
[25] D. Baker,et al. A Vast Repertoire of Dscam Binding Specificities Arises from Modular Interactions of Variable Ig Domains , 2007, Cell.
[26] R. Krumlauf. Hox genes in vertebrate development , 1994, Cell.
[27] Y. Jan,et al. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. , 1987, Science.
[28] K. White,et al. Versatile P(acman) BAC Libraries for Transgenesis Studies in Drosophila melanogaster , 2009, Nature Methods.
[29] Nele A. Haelterman,et al. Large-scale identification of chemically induced mutations in Drosophila melanogaster , 2014, Genome research.
[30] S. Ritchie,et al. The wMel Wolbachia strain blocks dengue and invades caged Aedes aegypti populations , 2011, Nature.
[31] S. Ritchie,et al. Successful establishment of Wolbachia in Aedes populations to suppress dengue transmission , 2011, Nature.
[32] J. Ott,et al. Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.
[33] Saraswati Sukumar,et al. The Hox genes and their roles in oncogenesis , 2010, Nature Reviews Cancer.
[34] T. Markello,et al. NT5E mutations and arterial calcifications. , 2011, The New England journal of medicine.
[35] E. Boerwinkle,et al. dbNSFP: A Lightweight Database of Human Nonsynonymous SNPs and Their Functional Predictions , 2011, Human mutation.
[36] T. Jentsch. Neuronal KCNQ potassium channels:physislogy and role in disease , 2000, Nature Reviews Neuroscience.
[37] Julie H. Simpson,et al. Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly , 2011, Neuron.
[38] Jongkyeong Chung,et al. Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. , 2007, Biochemical and biophysical research communications.
[39] W. Sullivan,et al. The genetics and cell biology of Wolbachia-host interactions. , 2008, Annual review of genetics.
[40] Hugo J. Bellen,et al. The C8ORF38 homologue Sicily is a cytosolic chaperone for a mitochondrial complex I subunit , 2013, The Journal of cell biology.
[41] P. Ricciardi-Castagnoli,et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.
[42] E. Green,et al. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.
[43] S. Artavanis-Tsakonas,et al. Notch and disease: a growing field. , 2012, Seminars in cell & developmental biology.
[44] C. Dahmann,et al. Characterization of the Drosophila Ortholog of the Human Usher Syndrome Type 1G Protein Sans , 2009, PloS one.
[45] Melissa M. Harrison,et al. Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease , 2013, Genetics.
[46] D. Haussler,et al. The Somatic Genomic Landscape of Glioblastoma , 2013, Cell.
[47] M. Tessier-Lavigne,et al. DSCAM Is a Netrin Receptor that Collaborates with DCC in Mediating Turning Responses to Netrin-1 , 2008, Cell.
[48] K. Zhu,et al. Transgenesis and paratransgenesis to control insect-borne diseases: current status and future challenges. , 2010, Parasitology international.
[49] A. Sturtevant,et al. Genetic Factors Affecting the Strength of Linkage in Drosophila. , 1917, Proceedings of the National Academy of Sciences of the United States of America.
[50] H. Muller. Types of visible variations induced by X-rays inDrosophila , 1930, Journal of Genetics.
[51] J. Shendure,et al. Exome sequencing as a tool for Mendelian disease gene discovery , 2011, Nature Reviews Genetics.
[52] W. Haining,et al. The proapoptotic function of Drosophila Hid is conserved in mammalian cells. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[53] Peggy Hall,et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations , 2013, Nucleic Acids Res..
[54] Shu Kondo,et al. Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila , 2013, Genetics.
[55] L. Pardo,et al. Ether-à-go-go encodes a voltage-gated channel permeable to K+ and Ca2+ and modulated by cAMP , 1993, Nature.
[56] D. Kleinjan,et al. Long-range control of gene expression: emerging mechanisms and disruption in disease. , 2005, American journal of human genetics.
[57] Nele A. Haelterman,et al. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes , 2011, Nature Methods.
[58] G. Rubin,et al. Molecular characterization of the drosophila trp locus: A putative integral membrane protein required for phototransduction , 1989, Neuron.
[59] T. Maniatis,et al. Clustered protocadherins , 2013, Development.
[60] G M Rubin,et al. A brief history of Drosophila's contributions to genome research. , 2000, Science.
[61] Andreas Hess,et al. A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene , 2010, Cell.
[62] A. Spradling,et al. The Drosophila Gene Disruption Project: Progress Using Transposons With Distinctive Site Specificities , 2011, Genetics.
[63] Param Priya Singh,et al. On the expansion of "dangerous" gene repertoires by whole-genome duplications in early vertebrates. , 2012, Cell reports.
[64] G. Dimopoulos,et al. Engineered Anopheles Immunity to Plasmodium Infection , 2011, PLoS pathogens.
[65] M. MacDonald,et al. Palmitoyl-Protein Thioesterase 1 Deficiency in Drosophila melanogaster Causes Accumulation of Abnormal Storage Material and Reduced Life Span , 2006, Genetics.
[66] Xun Huang,et al. Drosophila models of peroxisomal biogenesis disorder: peroxins are required for spermatogenesis and very-long-chain fatty acid metabolism. , 2010, Human molecular genetics.
[67] K. Marder,et al. RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk , 2013, Neuron.
[68] David R. Murdock,et al. Whole-Genome Sequencing for Optimized Patient Management , 2011, Science Translational Medicine.
[69] M. Fraser. Insect transgenesis: current applications and future prospects. , 2012, Annual review of entomology.
[70] F. Kafatos,et al. Arthropod-borne diseases: vector control in the genomics era , 2005, Nature Reviews Microbiology.
[71] H. Bellen,et al. Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells , 2012, PLoS biology.
[72] G. Mardon,et al. Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress , 2004, Development.
[73] V. Mulligan,et al. Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli , 2005, The Journal of cell biology.
[74] Casey S. Greene,et al. Functional Knowledge Transfer for High-accuracy Prediction of Under-studied Biological Processes , 2013, PLoS Comput. Biol..
[75] E. Larschan,et al. Wisdom from the fly. , 2014, Trends in genetics : TIG.
[76] A. Sturtevant. The Effects of Unequal Crossing over at the Bar Locus in Drosophila. , 1925, Genetics.
[77] B. Nilius,et al. The transient receptor potential family of ion channels , 2011, Genome Biology.
[78] Xiang-Dong Fu,et al. CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration , 2014, Cell.
[79] H. Bellen,et al. Introduction to Notch signaling. , 2014, Methods in molecular biology.
[80] Peter A. Ryan,et al. A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya, and Plasmodium , 2009, Cell.
[81] Thomas C Kaufman,et al. New research resources at the Bloomington Drosophila Stock Center , 2010, Fly.
[82] Takashi Makino,et al. Ohnologs in the human genome are dosage balanced and frequently associated with disease , 2010, Proceedings of the National Academy of Sciences.
[83] G. Rubin,et al. Rescue of the Drosophila phototransduction mutation trp by germline transformation. , 1985, Science.
[84] T. Cho,et al. TRPV4-pathy, a novel channelopathy affecting diverse systems , 2010, Journal of Human Genetics.
[85] J. Kagan,et al. The Dorsoventral Regulatory Gene Cassette spätzle / Toll / cactus Controls the Potent Antifungal Response in Drosophila Adults , 2015 .
[86] M. Tafti,et al. Genetics of sleep and sleep disorders. , 2003, Frontiers in bioscience : a journal and virtual library.
[87] Gang Wu,et al. SGDB: a database of synthetic genes re-designed for optimizing protein over-expression , 2006, Nucleic Acids Res..
[88] T. Kaufman,et al. A New Resource for Characterizing X-Linked Genes in Drosophila melanogaster: Systematic Coverage and Subdivision of the X Chromosome With Nested, Y-Linked Duplications , 2010, Genetics.
[89] S. Fuss,et al. Mechanisms of odorant receptor gene choice in Drosophila and vertebrates , 2009, Molecular and Cellular Neuroscience.
[90] B. Dickson. Molecular Mechanisms of Axon Guidance , 2002, Science.
[91] Y. Jan,et al. Cloning of a probable potassium channel gene from mouse brain , 1988, Nature.
[92] M. Mathews,et al. An Interview with , 2009 .
[93] M. Field,et al. Rare Diseases and Orphan Products: Accelerating Research and Development , 2010 .
[94] B. Moussian. The apical plasma membrane of chitin‐synthesizing epithelia , 2012, Insect science.
[95] C. Janeway,et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity , 1997, Nature.
[96] A. Sturtevant,et al. REVERSE MUTATION OF THE BAR GENE CORRELATED WITH CROSSING OVER. , 1923, Science.
[97] R. Masland,et al. Neurite arborization and mosaic spacing in the mouse retina require DSCAM , 2008, Nature.
[98] G. Tear,et al. The Batten disease gene CLN3 is required for the response to oxidative stress , 2011, Human molecular genetics.
[99] J. Lupski,et al. Human CLP1 Mutations Alter tRNA Biogenesis, Affecting Both Peripheral and Central Nervous System Function , 2014, Cell.
[100] J. Ott,et al. Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.
[101] Emily H Turner,et al. Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome , 2010, Nature Genetics.
[102] S. Bray. Notch signalling: a simple pathway becomes complex , 2006, Nature Reviews Molecular Cell Biology.
[103] C. Nüsslein-Volhard,et al. Mutations affecting segment number and polarity in Drosophila , 1980, Nature.
[104] J. Lupski,et al. Clan Genomics and the Complex Architecture of Human Disease , 2011, Cell.
[105] N. Perrimon,et al. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. , 1993, Development.
[106] Hugo J. Bellen,et al. 100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future , 2010, Nature Reviews Neuroscience.
[107] Euan A Ashley,et al. Clinical interpretation and implications of whole-genome sequencing. , 2014, JAMA.
[108] K. F. Fajardo,et al. Three rare diseases in one Sib pair: RAI1, PCK1, GRIN2B mutations associated with Smith-Magenis Syndrome, cytosolic PEPCK deficiency and NMDA receptor glutamate insensitivity. , 2014, Molecular genetics and metabolism.
[109] J. C. Clemens,et al. Alternative Splicing of Drosophila Dscam Generates Axon Guidance Receptors that Exhibit Isoform-Specific Homophilic Binding , 2004, Cell.
[110] A. De Loof. Ecdysteroids, juvenile hormone and insect neuropeptides: Recent successes and remaining major challenges. , 2008, General and comparative endocrinology.
[111] M. Gerstein,et al. The Centers for Mendelian Genomics: A new large‐scale initiative to identify the genes underlying rare Mendelian conditions , 2012, American journal of medical genetics. Part A.
[112] Alfonso Martinez Arias,et al. Drosophila melanogaster and the development of biology in the 20th century. , 2008, Methods in molecular biology.
[113] H J Muller,et al. The Production of Mutations by X-Rays. , 1928, Proceedings of the National Academy of Sciences of the United States of America.
[114] N. Perrimon,et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. , 2014, Human molecular genetics.
[115] M. Field,et al. Rare Diseases and Orphan Products , 2010 .
[116] J. Chilton. Molecular mechanisms of axon guidance. , 2006, Developmental biology.
[117] Bo Zhang,et al. Highly Efficient Genome Modifications Mediated by CRISPR/Cas9 in Drosophila , 2013, Genetics.
[118] Stephen M. Mount,et al. The genome sequence of Drosophila melanogaster. , 2000, Science.
[119] Jean-Pierre Bouchard,et al. Mutations in the Mitochondrial Methionyl-tRNA Synthetase Cause a Neurodegenerative Phenotype in Flies and a Recessive Ataxia (ARSAL) in Humans , 2012, PLoS biology.
[120] Emily H Turner,et al. Targeted Capture and Massively Parallel Sequencing of Twelve Human Exomes , 2009, Nature.
[121] K. Matsuno,et al. Drosophila Carrying Pex3 or Pex16 Mutations Are Models of Zellweger Syndrome That Reflect Its Symptoms Associated with the Absence of Peroxisomes , 2011, PloS one.
[122] C. Nüsslein-Volhard,et al. Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster , 1984, Wilhelm Roux's archives of developmental biology.
[123] R. Schwabe,et al. The Yin and Yang of Toll-like receptors in cancer , 2014, Oncogene.
[124] M. Olson,et al. New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting. , 2006, Genetics.
[125] David P Bick,et al. Making a definitive diagnosis: Successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease , 2011, Genetics in Medicine.
[126] Michael Ashburner,et al. Drosophila: A laboratory handbook , 1990 .
[127] Ye Yin,et al. Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes , 2014, Genome Biology.
[128] B. Lemaître,et al. The Dorsoventral Regulatory Gene Cassette spätzle/Toll/cactus Controls the Potent Antifungal Response in Drosophila Adults , 1996, Cell.
[129] S. Kornbluth,et al. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm) , 2005, Journal of Cell Science.
[130] H. Jinnah,et al. Sleep Fragmentation and Motor Restlessness in a Drosophila Model of Restless Legs Syndrome , 2012, Current Biology.
[131] Bassem A. Hassan,et al. A fruitfly's guide to keeping the brain wired , 2007, EMBO reports.
[132] S. Akira,et al. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. , 1999, Journal of immunology.
[133] Masahito Yamagata,et al. Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina , 2008, Nature.
[134] C. Nüsslein-Volhard,et al. Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster , 1984, Wilhelm Roux's archives of developmental biology.
[135] Hervé Isambert,et al. Human Dominant Disease Genes Are Enriched in Paralogs Originating from Whole Genome Duplication , 2014, PLoS Comput. Biol..
[136] Janet Hemingway,et al. The molecular basis of insecticide resistance in mosquitoes. , 2004, Insect biochemistry and molecular biology.
[137] A. Sturtevant,et al. The Spatial Relations of Genes. , 1919, Proceedings of the National Academy of Sciences of the United States of America.
[138] Eric Boerwinkle,et al. A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases , 2014, Cell.
[139] Claude Bouchard,et al. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders , 2014 .
[140] H. Horvitz,et al. Genetic control of programmed cell death in the nematode C. elegans , 1986, Cell.
[141] Bodil N. Cass,et al. Stable Introduction of a Life-Shortening Wolbachia Infection into the Mosquito Aedes aegypti , 2009, Science.
[142] Karen Ocorr,et al. A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function , 2010, Cell.
[143] Sydney Brenner,et al. An interview with... Sydney Brenner. Interview by Errol C. Friedberg. , 2008, Nature reviews. Molecular cell biology.
[144] Emily H Turner,et al. Targeted Capture and Massively Parallel Sequencing of Twelve Human Exomes , 2009, Nature.
[145] D. Goldstein,et al. Genic Intolerance to Functional Variation and the Interpretation of Personal Genomes , 2013, PLoS genetics.
[146] J. Gusella,et al. dtorsin, the Drosophila Ortholog of the Early-Onset Dystonia TOR1A (DYT1), Plays a Novel Role in Dopamine Metabolism , 2011, PloS one.
[147] Kriston L. McGary,et al. Systematic discovery of nonobvious human disease models through orthologous phenotypes , 2010, Proceedings of the National Academy of Sciences.
[148] H. Jacob,et al. A timely arrival for genomic medicine , 2011, Genetics in Medicine.
[149] M. Vega,et al. The significance of toll-like receptors in human diseases. , 2009, Allergologia et immunopathologia.
[150] Jonathan E. Dickerson,et al. On the Origins of Mendelian Disease Genes in Man: The Impact of Gene Duplication , 2011, Molecular biology and evolution.
[151] J. Sanes,et al. Chemoaffinity Revisited: Dscams, Protocadherins, and Neural Circuit Assembly , 2010, Cell.
[152] M. Paine,et al. Directionally selected cytochrome P450 alleles are driving the spread of pyrethroid resistance in the major malaria vector Anopheles funestus , 2012, Proceedings of the National Academy of Sciences.
[153] Ali Bashir,et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster , 2011, Proceedings of the National Academy of Sciences.
[154] M. Affolter,et al. Fluorescent fusion protein knockout mediated by anti-GFP nanobody , 2011, Nature Structural &Molecular Biology.
[155] Errol C. Friedberg,et al. Sydney Brenner , 2008, Nature Reviews Molecular Cell Biology.
[156] G. Rubin,et al. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses , 2005, Neurobiology of Disease.
[157] M. Lyon. An Interview With... , 2004, Nature Reviews Genetics.
[158] H. Bellen,et al. Drosophila Tempura, a Novel Protein Prenyltransferase α Subunit, Regulates Notch Signaling Via Rab1 and Rab11 , 2014, PLoS biology.
[159] Ethan Bier,et al. Drosophila, the golden bug, emerges as a tool for human genetics , 2005, Nature Reviews Genetics.
[160] Taylor J. Maxwell,et al. Deep resequencing reveals excess rare recent variants consistent with explosive population growth , 2010, Nature communications.
[161] Daisuke Hattori,et al. Dscam-mediated cell recognition regulates neural circuit formation. , 2008, Annual review of cell and developmental biology.
[162] N. Perrimon,et al. Stringent Analysis of Gene Function and Protein–Protein Interactions Using Fluorescently Tagged Genes , 2012, Genetics.
[163] J. Lupski,et al. Human genome sequencing in health and disease. , 2012, Annual review of medicine.
[164] J. Shendure,et al. Adenylate cyclase 1 (ADCY1) mutations cause recessive hearing impairment in humans and defects in hair cell function and hearing in zebrafish. , 2014, Human molecular genetics.
[165] R. Ray,et al. The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. , 2008, Developmental biology.
[166] E. Vassos,et al. Ohnologs are overrepresented in pathogenic copy number mutations , 2013, Proceedings of the National Academy of Sciences.