Cancer prevention by tea: Evidence from laboratory studies.

The cancer preventive activities of tea (Camellia sinensis Theaceae) have been studied extensively. Inhibition of tumorigenesis by green tea extracts and tea polyphenols has been demonstrated in different animal models, including those for cancers of the skin, lung, oral cavity, esophagus, stomach, small intestine, colon, bladder, liver, pancreas, prostate, and mammary glands. Many studies in cell lines have demonstrated the modulation of signal transduction and metabolic pathways by (-)-epigallocatechin-3-gallate (EGCG), the most abundant and active polyphenol in green tea. These molecular events can result in cellular changes, such as enhancement of apoptosis, suppression of cell proliferation, and inhibition of angiogenesis. Nevertheless, the molecular mechanisms of inhibition of carcinogenesis in animals and humans remain to be further investigated. Future research directions in this area are discussed.

[1]  C. Blum,et al.  Suppression of tumorigenesis in the Apc(min) mouse: down-regulation of beta-catenin signaling by a combination of tea plus sulindac. , 2003, Carcinogenesis.

[2]  Ni Ai,et al.  Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. , 2003, Cancer research.

[3]  W. Shih,et al.  Inhibition of intestinal tumorigenesis in Apcmin/+ mice by (-)-epigallocatechin-3-gallate, the major catechin in green tea. , 2005, Cancer research.

[4]  M. You,et al.  Effect of Dietary Polyphenon E and EGCG on Lung Tumorigenesis in A/J Mice , 2010, Pharmaceutical Research.

[5]  William H. Bisson,et al.  Tea catechins as inhibitors of receptor tyrosine kinases: mechanistic insights and human relevance. , 2010, Pharmacological research.

[6]  E. A. Rogozin,et al.  Direct Inhibition of Insulin-Like Growth Factor-I Receptor Kinase Activity by (−)−Epigallocatechin-3-Gallate Regulates Cell Transformation , 2007, Cancer Epidemiology Biomarkers & Prevention.

[7]  M. Matsushima,et al.  Preventive effects of urinary bladder tumors induced by N‐butyl‐N‐(4‐hydroxybutyl)‐nitrosamine in rat by green tea leaves , 2003, International journal of urology : official journal of the Japanese Urological Association.

[8]  Jun-yan Hong,et al.  Inhibition of N-nitrosodiethylamine- and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced tumorigenesis in A/J mice by green tea and black tea. , 1992, Cancer research.

[9]  D. Sato.  Inhibition of urinary bladder tumors induced by N‐butyl‐N‐(4‐hydroxybutyl)‐nitrosamine in rats by green tea , 1999, International journal of urology : official journal of the Japanese Urological Association.

[10]  Z. Dong,et al.  Inhibition of activator protein 1 activity and cell growth by purified green tea and black tea polyphenols in H-ras-transformed cells: structure-activity relationship and mechanisms involved. , 1999, Cancer research.

[11]  I. Weinstein,et al.  EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells. , 2008, Cancer letters.

[12]  E. Choi,et al.  (-)-Epigallocatechin-3-gallate (EGCG) inhibits HGF-induced invasion and metastasis in hypopharyngeal carcinoma cells. , 2008, Cancer letters.

[13]  A. Biggeri,et al.  Effects of black tea, green tea and wine extracts on intestinal carcinogenesis induced by azoxymethane in F344 rats. , 2000, Carcinogenesis.

[14]  M. Brausi,et al.  The chemopreventive action of catechins in the TRAMP mouse model of prostate carcinogenesis is accompanied by clusterin over-expression. , 2004, Carcinogenesis.

[15]  Chung S. Yang,et al.  Green tea polyphenols inhibit colorectal aberrant crypt foci (ACF) formation and prevent oncogenic changes in dysplastic ACF in azoxymethane-treated F344 rats. , 2007, Carcinogenesis.

[16]  Ming You,et al.  A gene expression signature that can predict green tea exposure and chemopreventive efficacy of lung cancer in mice. , 2006, Cancer research.

[17]  M. Hung,et al.  Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival , 2006, British Journal of Cancer.

[18]  Hui You,et al.  Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and Atorvastatin , 2008, Clinical Cancer Research.

[19]  Helgi I. Ingólfsson,et al.  The inhibitory effect of (-)-epigallocatechin gallate on activation of the epidermal growth factor receptor is associated with altered lipid order in HT29 colon cancer cells. , 2007, Cancer research.

[20]  A. E. Rogers,et al.  Black tea and mammary gland carcinogenesis by 7,12-dimethylbenz[a]anthracene in rats fed control or high fat diets. , 1998, Carcinogenesis.

[21]  Y. Lou,et al.  Effects of tea, decaffeinated tea, and caffeine on UVB light-induced complete carcinogenesis in SKH-1 mice: demonstration of caffeine as a biologically important constituent of tea. , 1997, Cancer research.

[22]  J. Liao,et al.  Inhibition of Lung Carcinogenesis and Effects on Angiogenesis and Apoptosis in A/J Mice by Oral Administration of Green Tea , 2004, Nutrition and cancer.

[23]  A. Conney,et al.  Effects of Green Tea and High-Fat Diet on Arachidonic Acid Metabolism and Aberrant Crypt Foci Formation in an Azoxymethane-Induced Colon Carcinogenesis Mouse Model , 2003, Nutrition and cancer.

[24]  T. Kuzuhara,et al.  DNA and RNA as New Binding Targets of Green Tea Catechins* , 2006, Journal of Biological Chemistry.

[25]  Joshua J. Steffan,et al.  The Green Tea Polyphenol EGCG Potentiates the Antiproliferative Activity of c-Met and Epidermal Growth Factor Receptor Inhibitors in Non–small Cell Lung Cancer Cells , 2009, Clinical Cancer Research.

[26]  P. Maliakal,et al.  Inhibition of carcinogenesis by tea. , 1997, Nature.

[27]  Takuji Tanaka,et al.  (−)-Epigallocatechin Gallate Suppresses Azoxymethane-Induced Colonic Premalignant Lesions in Male C57BL/KsJ-db/db Mice , 2008, Cancer Prevention Research.

[28]  David M. Smith,et al.  Ester Bond-containing Tea Polyphenols Potently Inhibit Proteasome Activity in Vitro and in Vivo * , 2001, The Journal of Biological Chemistry.

[29]  V. Adhami,et al.  Effective Prostate Cancer Chemopreventive Intervention with Green Tea Polyphenols in the TRAMP Model Depends on the Stage of the Disease , 2009, Clinical Cancer Research.

[30]  S. Sang,et al.  Bioavailability issues in studying the health effects of plant polyphenolic compounds. , 2008, Molecular nutrition & food research.

[31]  S. Cai,et al.  (-)-Epigallocatechin-3-gallate inhibits growth of gastric cancer by reducing VEGF production and angiogenesis. , 2007, World journal of gastroenterology.

[32]  R. Schmoyer,et al.  Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. , 2004, Lung cancer.

[33]  M. You,et al.  A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. , 2000, Cancer research.

[34]  L. Wang,et al.  Inhibition of N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats by green and black tea. , 1995, Carcinogenesis.

[35]  V. Adhami,et al.  Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I–Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer , 2004, Cancer Research.

[36]  Shujun Cheng,et al.  Experimental studies of the inhibitory effects of green tea catechin on mice large intestinal cancers induced by 1,2-dimethylhydrazine. , 1994, Cancer letters.

[37]  Chi Han,et al.  Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. , 2002, Carcinogenesis.

[38]  Y. Surh,et al.  Modulation of Nrf2-mediated antioxidant and detoxifying enzyme induction by the green tea polyphenol EGCG. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[39]  H. Bonkovsky.  Hepatotoxicity associated with supplements containing Chinese green tea (Camellia sinensis). , 2006, Annals of internal medicine.

[40]  Susan Biggin,et al.  Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin‐3‐gallate , 2001, Cancer.

[41]  A. Kong,et al.  Comparison of (−)-Epigallocatechin-3-Gallate Elicited Liver and Small Intestine Gene Expression Profiles Between C57BL/6J Mice and C57BL/6J/Nrf2 (−/−) Mice , 2005, Pharmaceutical Research.

[42]  Y. Lou,et al.  Topical applications of caffeine or (−)-epigallocatechin gallate (EGCG) inhibit carcinogenesis and selectively increase apoptosis in UVB-induced skin tumors in mice , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[43]  S. Shukla,et al.  Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re‐expression of GSTP1 in human prostate cancer cells , 2010, International journal of cancer.

[44]  R. S. Murugan,et al.  Modulatory effects of black tea polyphenols on oxidant–antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model , 2007, Journal of Gastroenterology.

[45]  Masumi Suzui,et al.  Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction. , 2002, Journal of experimental therapeutics & oncology.

[46]  M. Park,et al.  From Tpr-Met to Met, tumorigenesis and tubes , 2007, Oncogene.

[47]  Y. Fujimura,et al.  TLR4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor , 2010, The Journal of Immunology.

[48]  P. Kalaiselvi,et al.  Attenuation of senescence-induced oxidative exacerbations in aged rat brain by (−)-epigallocatechin-3-gallate , 2008, International Journal of Developmental Neuroscience.

[49]  H. Sakai,et al.  (-)-Epigallocatechin gallate inhibits growth and activation of the VEGF/VEGFR axis in human colorectal cancer cells. , 2010, Chemico-biological interactions.

[50]  Joshua J. Steffan,et al.  The polyphenol epigallocatechin‐3‐gallate affects lipid rafts to block activation of the c‐Met receptor in prostate cancer cells , 2010, Molecular carcinogenesis.

[51]  J. Lewin,et al.  Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[52]  Takuji Tanaka,et al.  The modifying effects of green tea polyphenols on acute colitis and inflammation‐associated colon carcinogenesis in male ICR mice , 2010, BioFactors.

[53]  Y. P. Lu,et al.  Inhibitory effects of orally administered green tea, black tea, and caffeine on skin carcinogenesis in mice previously treated with ultraviolet B light (high-risk mice): relationship to decreased tissue fat. , 2001, Cancer research.

[54]  V. Steele,et al.  Effect of Tea Extracts, Polyphenols, and Epigallocatechin Gallate on Azoxymethane-induced Colon Cancer , 1998, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[55]  S. Cho,et al.  Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. , 2008, Bioorganic & medicinal chemistry.

[56]  S. Sang,et al.  Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[57]  Y. P. Lu,et al.  Effects of oral administration of tea, decaffeinated tea, and caffeine on the formation and growth of tumors in high-risk SKH-1 mice previously treated with ultraviolet B light. , 1999, Nutrition and cancer.

[58]  H. Fujiki,et al.  Effect of (-)-epigallocatechin gallate, the main constituent of green tea, on lung metastasis with mouse B16 melanoma cell lines. , 1992, Cancer letters.

[59]  S. Sang,et al.  Possible controversy over dietary polyphenols: benefits vs risks. , 2007, Chemical research in toxicology.

[60]  I. Weinstein,et al.  EGCG inhibits activation of the insulin-like growth factor-1 receptor in human colon cancer cells. , 2005, Biochemical and biophysical research communications.

[61]  Weiya Ma,et al.  (-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78. , 2006, Cancer research.

[62]  M. Carpenter,et al.  Resveratrol, but not EGCG, in the diet suppresses DMBA-induced mammary cancer in rats , 2006, Journal of carcinogenesis.

[63]  L. Kopelovich,et al.  (−)-Epigallocatechin Gallate and Polyphenon E Inhibit Growth and Activation of the Epidermal Growth Factor Receptor and Human Epidermal Growth Factor Receptor-2 Signaling Pathways in Human Colon Cancer Cells , 2005, Clinical Cancer Research.

[64]  Y. Lou,et al.  Stimulatory effect of oral administration of tea, coffee or caffeine on UVB-induced apoptosis in the epidermis of SKH-1 mice. , 2007, Toxicology and applied pharmacology.

[65]  Jen-kun Lin,et al.  Inhibition of cyclin‐dependent kinases 2 and 4 activities as well as induction of cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (−)‐epigallocatechin‐3‐gallate , 1999, Journal of cellular biochemistry.

[66]  Weimin Guo,et al.  Green tea catechin, epigallocatechin‐3‐gallate, inhibits vascular endothelial growth factor angiogenic signaling by disrupting the formation of a receptor complex , 2006, International journal of cancer.

[67]  Chung S. Yang,et al.  DOSE-DEPENDENT LEVELS OF EPIGALLOCATECHIN-3-GALLATE IN HUMAN COLON CANCER CELLS AND MOUSE PLASMA AND TISSUES , 2006, Drug Metabolism and Disposition.

[68]  A. Bode,et al.  (-)-Epigallocatechin Gallate Regulates CD3-mediated T Cell Receptor Signaling in Leukemia through the Inhibition of ZAP-70 Kinase* , 2008, Journal of Biological Chemistry.

[69]  Y. Ohkura,et al.  Combination cancer chemoprevention with green tea extract and sulindac shown in intestinal tumor formation in Min mice , 2001, Journal of Cancer Research and Clinical Oncology.

[70]  D. Bartel.  MicroRNAs: Target Recognition and Regulatory Functions , 2009, Cell.

[71]  D. Gingras,et al.  Green tea polyphenol (-)-epigallocatechin 3-gallate inhibits MMP-2 secretion and MT1-MMP-driven migration in glioblastoma cells. , 2002, Biochimica et biophysica acta.

[72]  P. Kalaiselvi,et al.  Repletion of antioxidant status by EGCG and retardation of oxidative damage induced macromolecular anomalies in aged rats , 2008, Experimental Gerontology.

[73]  B. Frei,et al.  Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions , 2003, Critical reviews in food science and nutrition.

[74]  K. Kiura,et al.  (–)-Epigallocatechin gallate can prevent cisplatin-induced lung tumorigenesis in A/J mice , 2000 .

[75]  Jen-kun Lin,et al.  Suppression of extracellular signals and cell proliferation through EGF receptor binding by (−)‐epigallocatechin gallate in human A431 epidermoid carcinoma cells , 1997, Journal of cellular biochemistry.

[76]  Fei Guan,et al.  Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro. , 2010, Carcinogenesis.

[77]  H. Fujiki,et al.  Inhibition of N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis by (-)-epigallocatechin gallate in the rat glandular stomach. , 1995, Cancer research.

[78]  Xin Wang,et al.  Cancer prevention by tea: animal studies, molecular mechanisms and human relevance , 2009, Nature Reviews Cancer.

[79]  T. Libermann,et al.  Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. , 2004, Cancer cell.

[80]  Z. Dong,et al.  Mechanisms of inhibition of the Ras‐MAP kinase signaling pathway in 30.7b Ras 12 cells by tea polyphenols (‐)‐epigallocatechin‐3‐gallate and theaflavin‐3,3′‐digallate1 , 2001, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[81]  F. García-Cánovas,et al.  The antifolate activity of tea catechins. , 2005, Cancer research.

[82]  S. Cox,et al.  Modulation of aflatoxin biomarkers in human blood and urine by green tea polyphenols intervention. , 2008, Carcinogenesis.

[83]  J. Schwartz,et al.  Molecular and cellular effects of green tea on oral cells of smokers: a pilot study. , 2005, Molecular nutrition & food research.

[84]  Gang Lu,et al.  Inhibition of lung cancer growth in mice by dietary mixed tocopherols. , 2009, Molecular nutrition & food research.

[85]  Gang Lu,et al.  Inhibition of carcinogenesis by tea constituents. , 2007, Seminars in cancer biology.

[86]  Yong-Yeon Cho,et al.  Fyn is a novel target of (−)‐epigallocatechin gallate in the inhibition of JB6 Cl41 cell transformation , 2008, Molecular carcinogenesis.

[87]  Jie Liao,et al.  Inhibition of adenoma progression to adenocarcinoma in a 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis model in A/J mice by tea polyphenols and caffeine. , 2006, Cancer research.

[88]  Z. Y. Wang,et al.  Tea and cancer. , 1993, Journal of the National Cancer Institute.

[89]  J. Cardelli,et al.  The green tea catechins, (−)-Epigallocatechin-3-gallate (EGCG) and (−)-Epicatechin-3-gallate (ECG), inhibit HGF/Met signaling in immortalized and tumorigenic breast epithelial cells , 2006, Oncogene.

[90]  T. Kwok,et al.  Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. , 2010, The Journal of nutritional biochemistry.

[91]  M. You,et al.  Lung Cancer Inhibitory Effect of Epigallocatechin-3-Gallate Is Dependent on Its Presence in a Complex Mixture (Polyphenon E) , 2009, Cancer Prevention Research.

[92]  Gary Williamson,et al.  A review of the health effects of green tea catechins in in vivo animal models. , 2004, The Journal of nutrition.

[93]  Z. Selvanayagam,et al.  Gene expression changes induced by green tea polyphenol (-)-epigallocatechin-3-gallate in human bronchial epithelial 21BES cells analyzed by DNA microarray. , 2004, Molecular cancer therapeutics.

[94]  S. Amin,et al.  Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants. , 1992, Cancer research.

[95]  V. Steele,et al.  Preventive effects of Polyphenon E on urinary bladder and mammary cancers in rats and correlations with serum and urine levels of tea polyphenols , 2007, Molecular Cancer Therapeutics.

[96]  J. Liao,et al.  Information Of Lung Tumorigenesis By Tea , 2004, Experimental lung research.

[97]  A. Joe,et al.  (-)-Epigallocatechin gallate causes internalization of the epidermal growth factor receptor in human colon cancer cells. , 2008, Carcinogenesis.

[98]  S. Amin,et al.  Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent. , 1998, Cancer research.

[99]  A. Albini,et al.  Tumor invasion: molecular shears blunted by green tea , 1999, Nature Medicine.

[100]  B. Reddy,et al.  Interactive suppression of aberrant crypt foci induced by azoxymethane in rat colon by phytic acid and green tea. , 1997, Carcinogenesis.

[101]  G. Yang,et al.  Inhibition of growth and induction of apoptosis in human cancer cell lines by tea polyphenols. , 1998, Carcinogenesis.

[102]  Y. Lou,et al.  Administration of green tea or caffeine enhances the disappearance of UVB-induced patches of mutant p53 positive epidermal cells in SKH-1 mice. , 2005, Carcinogenesis.

[103]  Y. Fujimura,et al.  A receptor for green tea polyphenol EGCG , 2004, Nature Structural &Molecular Biology.

[104]  T. Ishii,et al.  Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation. , 2008, Free radical biology & medicine.

[105]  L. Ellis,et al.  Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. , 2002, The Journal of nutrition.

[106]  Koji Yamada,et al.  A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression. , 2005, Biochemical and biophysical research communications.

[107]  Weiya Ma,et al.  Inhibition of tumor promoter-induced activator protein 1 activation and cell transformation by tea polyphenols, (-)-epigallocatechin gallate, and theaflavins. , 1997, Cancer research.

[108]  M. Hirose,et al.  Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses. , 2002, Cancer Letters.

[109]  A. E. Rogers,et al.  Green tea extracts decrease carcinogen‐induced mammary tumor burden in rats and rate of breast cancer cell proliferation in culture , 2001, Journal of cellular biochemistry.

[110]  D. Alberts,et al.  Modulation of Human Glutathione S-Transferases by Polyphenon E Intervention , 2007, Cancer Epidemiology Biomarkers & Prevention.

[111]  Daniela K. Nitcheva,et al.  Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐ApcMin/+ mouse model of intestinal cancer , 2009, Molecular carcinogenesis.

[112]  Koji Yamada,et al.  Green Tea Polyphenol Epigallocatechin-3-gallate Signaling Pathway through 67-kDa Laminin Receptor* , 2008, Journal of Biological Chemistry.

[113]  A. Bode,et al.  The Intermediate Filament Protein Vimentin Is a New Target for Epigallocatechin Gallate* , 2005, Journal of Biological Chemistry.

[114]  John Calvin Reed,et al.  Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic Bcl-2-family proteins. , 2003, Cancer research.

[115]  Feng Zhu,et al.  Epigallocatechin Gallate Suppresses Lung Cancer Cell Growth through Ras–GTPase-Activating Protein SH3 Domain-Binding Protein 1 , 2010, Cancer Prevention Research.

[116]  W. Birchmeier,et al.  Met, metastasis, motility and more , 2003, Nature Reviews Molecular Cell Biology.

[117]  G. Yang,et al.  Inhibition of spontaneous formation of lung tumors and rhabdomyosarcomas in A/J mice by black and green tea. , 1998, Carcinogenesis.

[118]  Gang Lu,et al.  Inhibition of Intestinal Tumorigenesis in Apc Min/+ Mice by Green Tea Polyphenols (Polyphenon E) and Individual Catechins , 2007, Nutrition and cancer.

[119]  H. Schut,et al.  Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. , 1996, Carcinogenesis.

[120]  G. Yang,et al.  Black tea constituents, theaflavins, inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice. , 1997, Carcinogenesis.