Anatomically-based musculoskeletal modeling: prediction and validation of muscle deformation during walking

Accurate modeling of the musculoskeletal system during motion is a challenging task that has not yet been solved. In this paper, we outline and validate a free-form deformation method called the Host Mesh Fitting (HMF) technique for predicting muscle deformation during walking of a subject-specific musculoskeletal model. 20 lower limb muscles were deformed according to the HMF solution of a surrounding host mesh that resembled the skin boundary, resulting in a realistic walking simulation of the anatomically-based model. The shape changes of five muscles were further validated by comparing the predicted deformations with magnetic resonance image data in two lower limb positions.

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