Class II MHC Expression Inhibition of Class II Transactivator and β The Smad 3 Protein Is Involved in TGF-Benveniste

[1]  M. Gimbrone,et al.  Inhibition of E-Selectin Gene Expression by Transforming Growth Factor β in Endothelial Cells Involves Coactivator Integration of Smad and Nuclear Factor κB–Mediated Signals , 2000, The Journal of experimental medicine.

[2]  J. Harton,et al.  Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression , 2000, Molecular and Cellular Biology.

[3]  V. Nguyen,et al.  Involvement of STAT-1 and Ets Family Members in Interferon-γ Induction of CD40 Transcription in Microglia/Macrophages* , 2000, The Journal of Biological Chemistry.

[4]  H. Lodish,et al.  Role of transforming growth factor beta in human disease. , 2000, The New England journal of medicine.

[5]  W. Reith,et al.  CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. , 2000, Genes & development.

[6]  J. Massagué,et al.  Transcriptional control by the TGF‐β/Smad signaling system , 2000 .

[7]  K. Miyazono,et al.  c-Ski Acts as a Transcriptional Co-repressor in Transforming Growth Factor-β Signaling through Interaction with Smads* , 1999, The Journal of Biological Chemistry.

[8]  A. Roberts TGF-β signaling from receptors to the nucleus , 1999 .

[9]  S. Wahl,et al.  Manipulation of TGF-β to control autoimmune and chronic inflammatory diseases , 1999 .

[10]  J. Ting,et al.  Differential selectivity of CIITA promoter activation by IFN-γ and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-α , 1999, Journal of Neuroimmunology.

[11]  B. Peterlin,et al.  The class II transactivator CIITA is a transcriptional integrator. , 1999, Microbes and infection.

[12]  J. Ting,et al.  Class II MHC genes: a model gene regulatory system with great biologic consequences. , 1999, Microbes and infection.

[13]  Qiang Zhou,et al.  The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. , 1999, Genes & development.

[14]  E. Benveniste,et al.  IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes. , 1999, Journal of immunology.

[15]  J. Massagué,et al.  A Smad Transcriptional Corepressor , 1999, Cell.

[16]  A. Roberts,et al.  Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.

[17]  J. Ting,et al.  Two Distinct Gamma Interferon-Inducible Promoters of the Major Histocompatibility Complex Class II Transactivator Gene Are Differentially Regulated by STAT1, Interferon Regulatory Factor 1, and Transforming Growth Factor β , 1999, Molecular and Cellular Biology.

[18]  M. Merika,et al.  Involvement of CREB Binding Protein in Expression of Major Histocompatibility Complex Class II Genes via Interaction with the Class II Transactivator , 1998, Molecular and Cellular Biology.

[19]  C. Heldin,et al.  Identification and Functional Characterization of a Smad Binding Element (SBE) in the JunB Promoter That Acts as a Transforming Growth Factor-β, Activin, and Bone Morphogenetic Protein-inducible Enhancer* , 1998, The Journal of Biological Chemistry.

[20]  C. Deng,et al.  Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[21]  E. Li,et al.  Smad2 role in mesoderm formation, left–right patterning and craniofacial development , 1998, Nature.

[22]  B. Mach,et al.  Quantitative control of MHC class II expression by the transactivator CIITA , 1998, European journal of immunology.

[23]  B. Mach,et al.  Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1. , 1998, Immunity.

[24]  J. Ting,et al.  Identification of Distinct Regions of 5′ Flanking DNA That Mediate Constitutive, IFN-γ, STAT1, and TGF-β-Regulated Expression of the Class II Transactivator Gene , 1998, The Journal of Immunology.

[25]  J. Strominger,et al.  Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[26]  B. Peterlin,et al.  The class II trans-activator CIITA interacts with the TBP-associated factor TAFII32. , 1997, Nucleic acids research.

[27]  B. Mach,et al.  Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA , 1997, The EMBO journal.

[28]  R. Ransohoff,et al.  TGF-beta suppresses IFN-gamma induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression. , 1997, Journal of immunology.

[29]  A. Kulkarni,et al.  Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression. , 1996, The Journal of clinical investigation.

[30]  R. Flavell,et al.  Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. , 1996, Immunity.

[31]  J. Darnell,et al.  Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation , 1995, Cell.

[32]  Y. Lee,et al.  TGF-beta suppression of IFN-gamma-induced class II MHC gene expression does not involve inhibition of phosphorylation of JAK1, JAK2, or signal transducers and activators of transcription, or modification of IFN-gamma enhanced factor X expression. , 1995, Journal of immunology.

[33]  Y. Lee,et al.  Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-alpha-mediated class II MHC gene expression. , 1994, Journal of immunology.

[34]  R. Flavell,et al.  Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes , 1994, The Journal of experimental medicine.

[35]  B. Mach,et al.  Regulation of MHC class II expression by interferon-gamma mediated by the transactivator gene CIITA. , 1994, Science.

[36]  J. W. Rooney,et al.  Transforming growth factor beta 1 repression of the HLA-DR alpha gene is mediated by conserved proximal promoter elements. , 1993, Journal of immunology.

[37]  F. Ruscetti,et al.  Pleiotropic Effects of Transforming Growth Factor‐β on Cells of the Immune System , 1993, Annals of the New York Academy of Sciences.

[38]  G. Proetzel,et al.  Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease , 1992, Nature.

[39]  L. Matrisian,et al.  TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence , 1990, Cell.

[40]  G. Wong,et al.  Transforming growth factor-beta 1 modulates the expression of class II histocompatibility antigens on human cells. , 1988, Journal of immunology.

[41]  M. Sporn,et al.  Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth , 1986, The Journal of experimental medicine.

[42]  L. Eng,et al.  Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. , 1972, Brain research.

[43]  D. Singer,et al.  Transcriptional coactivator, CIITA, is an acetyltransferase that bypasses a promoter requirement for TAF(II)250. , 2001, Molecular cell.

[44]  J. Massagué,et al.  Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. , 1999, Nature.

[45]  A. Roberts,et al.  Regulation of immune responses by TGF-beta. , 1998, Annual review of immunology.

[46]  J. Massagué,et al.  TGF- SIGNAL TRANSDUCTION , 1998 .

[47]  Y. Lee,et al.  Regulation of class II MHC expression. , 1996, Critical reviews in immunology.

[48]  L. Glimcher,et al.  Immune responses in MHC class II-deficient mice. , 1995, Annual Review of Immunology.