Olfactory identification deficits in patients with focal cerebral excision

The ability to identify common odors using the University of Pennsylvania Smell Identification Test was investigated in 120 patients with a focal surgical brain lesion and 20 normal control subjects. Results showed significant impairment after right or left temporal lobectomy, right or left frontal lobectomy, and right frontotemporal excision. Patients whose excision was confined to the left central, parietal or posterior area showed no significant deficit. The impairment after frontal lobectomy was demonstrated only in patients whose frontal-lobe removal invaded the orbital cortex; that group also showed a significantly greater impairment than did the temporal lobectomy group. All patient groups showed normal detection thresholds for n-butyl alcohol.

[1]  T. Tanabe,et al.  An olfactory projection area in orbitofrontal cortex of the monkey. , 1975, Journal of neurophysiology.

[2]  W. Cain.  CONTRIBUTION OF THE TRIGEMINAL NERVE TO PERCEIVED ODOR MAGNITUDE * , 1974 .

[3]  J. Price,et al.  Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat , 1977, The Journal of comparative neurology.

[4]  W. F. Allen.  EFFECT OF ABLATING THE FRONTAL LOBES, HIPPOCAMPI, AND OCCIPITO-PARIETO-TEMPORAL (EXCEPTING PYRIFORM AREAS) LOBES ON POSITIVE AND NEGATIVE OLFACTORY CONDITIONED REFLEXES , 1940 .

[5]  Paul H. Crandall,et al.  Olfactory Memory in Patients with Anterior Temporal Lobectomy , 1977, Cortex.

[6]  W. F. Allen.  EFFECT OF ABLATING THE PYRIFORM-AMYGDALOID AREAS AND HIPPOCAMPI ON POSITIVE AND NEGATIVE OLFACTORY CONDITIONED REFLEXES AND ON CONDITIONED OLFACTORY DIFFERENTIATION , 1941 .

[7]  W S Cain,et al.  Clinical evaluation of olfaction. , 1983, American journal of otolaryngology.

[8]  H. Jasper,et al.  Book Reviews: Epilepsy and the Functional Anatomy of the Human Brain , 1954 .

[9]  R. Henkin,et al.  Defects in taste and smell recognition following temporal lobectomy. , 1977, Transactions of the American Neurological Association.

[10]  W. Cain,et al.  Olfactory functioning in temporal lobectomy patients , 1983, Neuropsychologia.

[11]  R. Doty,et al.  Development of the university of pennsylvania smell identification test: A standardized microencapsulated test of olfactory function , 1984, Physiology & Behavior.

[12]  H. Eichenbaum,et al.  Thalamocortical Mechanisms in Odor-Guided Behavior , 1980 .

[13]  Deepak N. Pandya,et al.  Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. II. Frontal lobe afferents , 1975, Brain Research.

[14]  A. Damasio,et al.  Olfactory dysfunction in man: Anatomical and behavioral aspects , 1982, Brain and Cognition.

[15]  R. Silverstein,et al.  Bark Beetle Pheromones , 1970, Nature.

[16]  T. Rasmussen,et al.  INTRACAROTID INJECTION OF SODIUM AMYTAL FOR THE LATERALIZATION OF CEREBRAL SPEECH DOMINANCE EXPERIMENTAL AND CLINICAL OBSERVATIONS , 1960 .

[17]  H Eichenbaum,et al.  Selective olfactory deficits in case H.M. , 1983, Brain : a journal of neurology.

[18]  D. G. Laing.  Optimum perception of odor intensity by humans , 1985, Physiology & Behavior.

[19]  William S. Cain,et al.  Odor perception in temporal lobe epilepsy patients with and without temporal lobectomy , 1986, Neuropsychologia.

[20]  R. Doty,et al.  Sex differences in odor identification ability: A cross-cultural analysis , 1985, Neuropsychologia.

[21]  P. Jurs,et al.  Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans , 1978, Physiology & Behavior.

[22]  A. Abraham,et al.  The effect of right temporal lobe lesions on matching of smells , 1983, Neuropsychologia.

[23]  The amygdala and hippocampus in olfactory aura. , 1967 .

[24]  J. Jackson,et al.  EPILEPTIC ATTACKS WITH A WARNING OF A CRUDE SENSATION OF SMELL AND WITH THE INTELLECTUAL AURA (DREAMY STATE) IN A PATIENT WHO HAD SYMPTOMS POINTING TO GROSS ORGANIC DISEASE OF THE RIGHT TEMPORO-SPHENOIDAL LOBE , 1899 .

[25]  H Eichenbaum,et al.  Thalamocortical mechanisms in odor-guided behavior. I. Effects of lesions of the mediodorsal thalamic nucleus and frontal cortex on olfactory discrimination in the rat. , 1980, Brain, behavior and evolution.

[26]  W. Scoville,et al.  LOSS OF RECENT MEMORY AFTER BILATERAL HIPPOCAMPAL LESIONS , 1957, Journal of neurology, neurosurgery, and psychiatry.

[27]  M Mishkin,et al.  The locus and cytoarchitecture of the projection areas of the olfactory bulb in Macaca mulatta , 1978, The Journal of comparative neurology.

[28]  Richard L. Doy,et al.  Internal consistency and short-term test-retest reliability of the University of Pennsylvania Smell Identification Test , 1985 .

[29]  W. Cain,et al.  Determinants of measured olfactory sensitivity , 1986, Perception & psychophysics.

[30]  E. Serafetinides,et al.  Specific alterations of olfactory function in humans with temporal lobe lesions , 1975, Nature.

[31]  Wayne L. Silver,et al.  Trigeminal chemoreception in the nasal and oral cavities , 1981 .

[32]  W. Nauta,et al.  A note on the problem of olfactory associations of the orbitofrontal cortex in the monkey , 1979, Neuroscience.

[33]  T. Rasmussen,et al.  INTRACAROTID SODIUM AMYTAL FOR THE LATERALIZATION OF CEREBRAL SPEECH DOMINANCE; OBSERVATIONS IN 123 PATIENTS. , 1964, Journal of neurosurgery.

[34]  N. Butters,et al.  An assessment of olfactory deficits in patients with damage to prefrontal cortex , 1980, Neuropsychologia.

[35]  B. Slotnick,et al.  Dual olfactory representation in the rat thalamus: An anatomical and electrophysiological study , 1983, The Journal of comparative neurology.

[36]  T. S. Brown,et al.  Olfactory discrimination after temporal lobe lesions in monkeys. , 1963 .

[37]  R. Doty,et al.  Influence of intertrial interval and sniff-bottle volume on phenyl ethyl alcohol odor detection thresholds , 1986 .