Correlação entre a classificação TNM, gradação histológica e localização anatômica em carcinoma epidermóide oral

The aim of this study was to investigate the existence of correlation between the TNM clinical classification, histologic malignancy grading and anatomical location of oral squamous cell carcinoma. A total of 120 oral squamous cell carcinomas were selected from the files of the Dr. Luiz Antonio Hospital (Natal, Rio Grande do Norte, Brazil). Data concerning TNM clinical classification and anatomical location of lesions were obtained. Histologic malignancy grading was carried out following the criteria defined by Wahi22 (1971). Pearson’s correlation test was applied for the statistical analysis of data. It revealed a statistically significant correlation (r = 0.2993, p = 0.01) between TNM clinical classification and histologic malignancy grading. It also revealed correlation between TNM classification and the anatomical location of oral squamous cell carcinomas (r = 0.4463, p = 0.01). We concluded that TNM classification presented correlation with histological grading and with the different anatomical locations of oral squamous cell carcinomas.

[1]  M. Bryne Is the invasive front of an oral carcinoma the most important area for prognostication? , 2008, Oral diseases.

[2]  E. Spitznagel,et al.  Development of a new staging system for recurrent oral cavity and oropharyngeal squamous cell carcinoma , 1999, Cancer.

[3]  F. Carinci,et al.  Is the new TNM (1997) the best system for predicting prognosis? , 1999, International journal of oral and maxillofacial surgery.

[4]  H. Iro,et al.  Evaluation of the newly updated TNM classification of head and neck carcinoma with data from 3247 patients , 1998, Cancer.

[5]  A. J. Oliver,et al.  Primary oral squamous cell carcinoma: a review of 92 cases. , 1996, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

[6]  L. Sobin,et al.  What do we need beyond TNM? , 1996, Cancer.

[7]  M Sherriff,et al.  The prognostic value of individual histologic grading parameters in small lingual squamous cell carcinomas. The importance of the pattern of invasion , 1994, Cancer.

[8]  C. Beltrami,et al.  Prognostic factors in squamous cell carcinoma of the oral cavity. A retrospective study of 80 cases. , 1992, Pathology, research and practice.

[9]  Magne Bryne,et al.  Malignancy grading of the deep invasive margins of oral squamous cell carcinomas has high prognostic value , 1992, The Journal of pathology.

[10]  C. O'brien,et al.  Squamous cell carcinoma of the buccal mucosa: analysis of prognostic factors. , 1987, American journal of surgery.

[11]  G Anneroth,et al.  Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. , 1987, Scandinavian journal of dental research.

[12]  J. Lauris,et al.  Evaluation of health questionnaires used by dentists in Bauru and surroundings , 2000 .

[13]  Ö. Ünal,et al.  Possible prognostic value of histopathologic parameters in patients with carcinoma of the oral tongue , 1998, European Archives of Oto-Rhino-Laryngology.

[14]  C. Silfverswärd,et al.  Histological grading of malignancy in squamous cell carcinoma of the oral tongue. , 1982, Acta oto-laryngologica.