Uric acid correlates to oxidation and inflammation in opposite directions in women

Abstract Objective: To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation. Methods: Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women. Results: Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine. Conclusions: Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.

[1]  P. Lévy,et al.  Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia , 2013, Fundamental & clinical pharmacology.

[2]  N. Rothman,et al.  Adiposity and Fat Distribution in relation to Inflammation and Oxidative Stress in a Relatively Lean Population of Chinese Women , 2013, Disease markers.

[3]  X. Shu,et al.  Purine-rich foods, protein intake, and the prevalence of hyperuricemia: the Shanghai Men's Health Study. , 2012, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[4]  B. Álvarez-Lario,et al.  Is there anything good in uric acid? , 2011, QJM : monthly journal of the Association of Physicians.

[5]  N. Rothman,et al.  Obesity, age, and oxidative stress in middle-aged and older women. , 2011, Antioxidants & redox signaling.

[6]  B. Halliwell,et al.  Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress? , 2011, Free radical biology & medicine.

[7]  M. Hershfield,et al.  Treating gout with pegloticase, a PEGylated urate oxidase, provides insight into the importance of uric acid as an antioxidant in vivo , 2010, Proceedings of the National Academy of Sciences.

[8]  K. Rock,et al.  Uric acid promotes an acute inflammatory response to sterile cell death in mice. , 2010, The Journal of clinical investigation.

[9]  X. Shu,et al.  Intra-Person Variation of Urinary Biomarkers of Oxidative Stress and Inflammation , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[10]  Y. Chan,et al.  Is uric acid protective or deleterious in acute ischemic stroke? A prospective cohort study. , 2010, Atherosclerosis.

[11]  Satoru Kodama,et al.  Association Between Serum Uric Acid and Development of Type 2 Diabetes , 2009, Diabetes Care.

[12]  Xuemei Huang,et al.  Plasma urate and Parkinson's disease in the Atherosclerosis Risk in Communities (ARIC) study. , 2009, American journal of epidemiology.

[13]  B. Rovin,et al.  Uric acid and cardiovascular risk. , 2009, The New England journal of medicine.

[14]  Giuseppe Lippi,et al.  High Serum Uric Acid as a Novel Risk Factor for Type 2 Diabetes , 2008, Diabetes Care.

[15]  Á. Chamorro,et al.  A Pilot Study of Dual Treatment With Recombinant Tissue Plasminogen Activator and Uric Acid in Acute Ischemic Stroke , 2007, Stroke.

[16]  X. Shu,et al.  Abdominal adiposity and mortality in Chinese women. , 2007, Archives of internal medicine.

[17]  J. Morrow,et al.  Quantification of F2-isoprostanes as a biomarker of oxidative stress , 2007, Nature Protocols.

[18]  Y. Dohi,et al.  Association among C-reactive protein, oxidative stress, and traditional risk factors in healthy Japanese subjects. , 2007, International journal of cardiology.

[19]  N. Rothman,et al.  Prospective study of urinary prostaglandin E2 metabolite and colorectal cancer risk. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  S. Bandinelli,et al.  Uric acid and inflammatory markers. , 2006, European heart journal.

[21]  N. Rothman,et al.  The Shanghai Women's Health Study: rationale, study design, and baseline characteristics. , 2005, American journal of epidemiology.

[22]  A. Hofman,et al.  Serum uric acid levels and the risk of Parkinson disease , 2005, Annals of neurology.

[23]  Hyon K. Choi,et al.  Pathogenesis of Gout , 2005, Annals of Internal Medicine.

[24]  Richard J. Johnson,et al.  A unifying pathway for essential hypertension. , 2005, American journal of hypertension.

[25]  D. Levy,et al.  Relations of Serum Uric Acid to Longitudinal Blood Pressure Tracking and Hypertension Incidence , 2005, Hypertension.

[26]  P. Mecocci,et al.  Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity. , 2004, Journal of cardiac failure.

[27]  B. Ainsworth,et al.  Reproducibility and validity of the Shanghai Women's Health Study physical activity questionnaire. , 2003, American journal of epidemiology.

[28]  D. Webb,et al.  Uric acid reduces exercise-induced oxidative stress in healthy adults. , 2003, Clinical science.

[29]  M. Walters,et al.  Serum Urate as an Independent Predictor of Poor Outcome and Future Vascular Events After Acute Stroke , 2003, Stroke.

[30]  K. Tuttle,et al.  Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? , 2003, Hypertension.

[31]  Sunil J Rao,et al.  Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis , 2003 .

[32]  T. Nakagawa,et al.  Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. , 2002, Hypertension.

[33]  Á. Chamorro,et al.  Prognostic Significance of Uric Acid Serum Concentration in Patients With Acute Ischemic Stroke , 2002, Stroke.

[34]  Frank E. Harrell,et al.  Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis , 2001 .

[35]  H. Brenner,et al.  Association between C-reactive protein and features of the metabolic syndrome: a population-based study. , 2000, Diabetes care.

[36]  Jing Fang,et al.  Serum Uric Acid and Cardiovascular Mortality: The NHANES I Epidemiologic Follow-up Study, 1971-1992 , 2000 .

[37]  W. Pryor,et al.  Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid. , 2000, Archives of biochemistry and biophysics.

[38]  J. Morrow,et al.  Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. , 2000, Free radical biology & medicine.

[39]  Daniel Levy,et al.  Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study , 1999, Annals of Internal Medicine.

[40]  B. Ames,et al.  Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[41]  J. Morrow,et al.  Quantification of F2-isoprostanes in biological fluids and tissues as a measure of oxidant stress. , 2007, Methods in enzymology.

[42]  Barry Halliwell,et al.  Oxidative stress and cancer: have we moved forward? , 2007, The Biochemical journal.

[43]  D. Leibfritz,et al.  Free radicals and antioxidants in normal physiological functions and human disease. , 2007, The international journal of biochemistry & cell biology.

[44]  Hiroyuki Tsutsui,et al.  [Oxidative stress and heart failure]. , 2006, Nihon rinsho. Japanese journal of clinical medicine.

[45]  D. Kang,et al.  Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. , 2005, Seminars in nephrology.

[46]  X. Shu,et al.  Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health Study , 2004, European Journal of Clinical Nutrition.

[47]  M. Alderman,et al.  Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. , 2000, JAMA.