Effect of oxygen inhalation on relaxation times in various tissues

The effect of the oxygen inhalation on relaxation times was evaluated in various tissues, including the myocardium, liver, spleen, skeletal muscle, subcutaneous fat, bone marrow, and arterial blood, with a [1H]MR system. Statistically significant decrease of T1 relaxation times was observed in the myocardium, spleen, and arterial blood after inhalation of 100% oxygen, whereas no significant change was observed in liver, skeletal muscle, subcutaneous fat, or bone marrow. The T2 relaxation time of these tissues did not differ significantly between before and after inhalation of the oxygen. These results indicate that [1H]MRI can be used to evaluate changes with oxygen inhalation and that the effect of the oxygen inhalation on T1 relaxation time is different among various tissues.

[1]  S. Ogawa,et al.  Oxygenation‐sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields , 1990, Magnetic resonance in medicine.

[2]  D. Tank,et al.  Brain magnetic resonance imaging with contrast dependent on blood oxygenation. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Linus Pauling,et al.  The Magnetic Properties and Structure of the Hemochromogens and Related Substances , 1936, Proceedings of the National Academy of Sciences.

[4]  P. Börnert,et al.  Fast perfluorocarbon imaging using 19F U‐FLARE , 1993, Magnetic resonance in medicine.

[5]  T. Floyd,et al.  Oxygen-sensitive 19F NMR imaging of the vascular system in vivo. , 1987, Magnetic resonance imaging.

[6]  H. Swan,et al.  Coronary Hemodynamics and Myocardial Oxygen Metabolism during Oxygen Breathing in Patients with and without Coronary Artery Disease , 1972, Circulation.

[7]  D M Kramer,et al.  Preliminary experimental results in humans and animals with a superconducting, whole-body, nuclear magnetic resonance scanner. , 1982, Radiology.

[8]  R. Turner,et al.  Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[9]  S. Sasayama,et al.  Is 300 msec too long for cardiac MR imaging? Feasibility study demonstrating changes in left ventricular cross-sectional area with use of single-shot turboFLASH imaging. , 1994, Radiology.

[10]  G M Bydder,et al.  Effect of oxygen tension on NMR spin-lattice relaxation rate of blood in vivo. , 1984, Investigative radiology.

[11]  S. Ogawa.  Brain magnetic resonance imaging with contrast-dependent oxygenation , 1990 .

[12]  B J SOBOL,et al.  Alteration of Coronary Blood Flow in the Dog by Inhalation of 100 Per Cent Oxygen , 1962, Circulation research.

[13]  J Hennig,et al.  Clinical applications and methodological developments of the RARE technique. , 1988, Magnetic resonance imaging.

[14]  L. J. Busse,et al.  MR imaging of the lung using liquid perfluorocarbons. , 1986, Journal of computer assisted tomography.

[15]  P. Antich,et al.  In vivo oxygen tension and temperature: Simultaneous determination using 19F NMR spectroscopy of perfluorocarbon , 1993, Magnetic resonance in medicine.

[16]  G. Satchell.  Physiology and Form of Fish Circulation: Circulation through special regions , 1991 .

[17]  R. Mason,et al.  Oxygen tension mapping with F‐19 echo‐planar MR imaging of sequestered perfluorocarbon , 1994, Journal of magnetic resonance imaging : JMRI.

[18]  John B. West.  Ventilation/Blood Flow and Gas Exchange , 1977 .

[19]  D. Delpy,et al.  19F NMR imaging of blood oxygenation in the brain , 1988, Magnetic resonance in medicine.

[20]  R. Deichmann,et al.  In vivo measurement of partial oxygen pressure in large vessels and in the reticuloendothelial system using fast 19F‐MRI , 1995, Magnetic resonance in medicine.

[21]  J R MacFall,et al.  Methodology for the measurement and analysis of relaxation times in proton imaging. , 1987, Magnetic resonance imaging.

[22]  G. Bydder,et al.  Enhancement of relaxation rate with paramagnetic contrast agents in NMR imaging. , 1981, The Journal of computed tomography.

[23]  A. D. de Crespigny,et al.  Endogenous susceptibility contrast in myocardium during apnea measured using gradient recalled echo planar imaging , 1993, Magnetic resonance in medicine.

[24]  R. Turner,et al.  Echo‐planar time course MRI of cat brain oxygenation changes , 1991, Magnetic resonance in medicine.

[25]  R A Brooks,et al.  Magnetic resonance imaging of stationary blood: a review. , 1987, Medical physics.

[26]  T J Brady,et al.  Iron in magnetic resonance imaging of cerebral hemorrhage. , 1989, Magnetic resonance quarterly.

[27]  V. P. Chacko,et al.  Oxygenation in the rabbit myocardium: assessment with susceptibility-dependent MR imaging. , 1993, Radiology.

[28]  P. Hees,et al.  Assessment of changes in murine tumor oxygenation in response to nicotinamide using 19F NMR relaxometry of a perfluorocarbon emulsion , 1993, Magnetic resonance in medicine.

[29]  Ravi S. Menon,et al.  Intrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[30]  P. Joseph,et al.  In vivo measurements of vascular oxygen tension in tumors using MRI of a fluorinated blood substitute. , 1989, Investigative radiology.

[31]  G. Radda,et al.  Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field. , 1982, Biochimica et biophysica acta.

[32]  J. Gore,et al.  Imaging oxygen tension in liver and spleen by 19F NMR , 1993, Magnetic resonance in medicine.

[33]  J. Gore,et al.  Relaxation Rate Enhancement Observed in Vivo By NMR Imaging , 1981 .