Long-Range Adaptive Fuzzy Control of Neuromuscular Blockade

Abstract An application of adaptive predictive fuzzy control to the neuromuscular blockade using a continuous infusion is presented. The proposed controller attemptsto minimize a quadratic multi-step cost using a receding horizon strategy. Using a (nonlinear) fuzzy model based predictive controller one may hope to extend the operation range of linear predictor based controllers. The adaptive feature of the controller is expected to cope with the variability of patient responses. The reported examples using simulated patients reinforce the claim of the usefulness of this approach