Adhesions, inflammatory response and foreign body giant cells infiltration of the topical hemostats TachoSil®, HemopatchTM and VerisetTM – An Animal Study

Background: When liver bleeding cannot be controlled by conventional methods, a topical hemostatic patch can be applied during surgery. In recent years new hemostats have become available. The aim of this study was to investigate the degree of adhesion and infl ammation for three topical hemostatic patches, TachoSil®, HemopatchTM and VerisetTM. Methods: In 60 adult male Sprague Dawley rats liver two lesions were induced with a scalpel. Each rat was treated with two of the three patches tested. After 1, 2 and 3 months the animals were euthanized and macroscopic evaluation of adhesions and histological assessment of infl ammation and macrophage infi ltration were performed. Results: A signifi cant higher (p<0.05) occurrence of foreign body giant cells (FBGCs) was found in HemopatchTM and VerisetTM, whereas both had a lower degree of infl ammatory and macrophage infi ltration compared to TachoSil®. No differences in the occurrence of adhesions were found. Conclusion: Our study found evidence for difference in infl ammation and formation of foreign body giant cells for the three hemostatic patches. Research Article Adhesions, infl ammatory response and foreign body giant cells infi ltration of the topical hemostats TachoSil®, HemopatchTM and VerisetTM – An Animal Study Line Schiøtt Nissen1, Jacob Hunter1, Henrik Daa Schrøder2, Kenneth Rütz3 and Peter Bollen1* 1Biomedical Laboatory, Faculty of Health Sciences, University of Southern Denmark 2Institute of Regional Health Services, Faculty of Health Sciences, University of Southern Denmark 3Department of Surgery, Odense University Hospital, Odense, Denmark Dates: Received: 06 July, 2017; Accepted: 14 August, 2017; Published: 16 August, 2017 *Corresponding author: Peter Bollen, Head of Department, Biomedical Laboratory, University of Southern Denmark, Denmark, Tel: +45 65503798; E-mail: