Using Computerized Cytomorphometry to Distinguish between Benign and Malignant Cases in Thyroid Fine‐Needle Aspiration Cytology

Only a small number of studies on computerized cytomorphometry have been performed for thyroid FNAC. The present study aimed to determine the usefulness of computerized cytomorphometry methods to further classify thyroid lesions as benign or malignant and to compare the practicability and value of using Papanicolaou (Pap) and Giemsa stains in thyroid FNAC by evaluating their association to various cytologic nuclear parameters.

[1]  Z. Canturk,et al.  Histologic outcome of thyroid nodules with repeated diagnosis of atypia in thyroid fine-needle aspiration biopsy. , 2016, Future oncology.

[2]  M. Kefeli,et al.  Risk factors associated with malignancy and with triage to surgery in thyroid nodules classified as Bethesda category III (AUS/FLUS). , 2016, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[3]  P. Arul,et al.  A correlative study of solitary thyroid nodules using the bethesda system for reporting thyroid cytopathology. , 2015, Journal of cancer research and therapeutics.

[4]  J. Shah,et al.  Malignancy rate in thyroid nodules classified as Bethesda category III (AUS/FLUS). , 2014, Thyroid : official journal of the American Thyroid Association.

[5]  P. Vitti,et al.  Follicular-derived neoplasms: Morphometric and genetic differences , 2013, Journal of Endocrinological Investigation.

[6]  Chung-Ming Chen,et al.  Preoperative prediction of papillary thyroid carcinoma prognosis with the assistance of computerized morphometry of cytology samples obtained by fine‐needle aspiration: Preliminary report , 2013, Head & neck.

[7]  B. Šarčević,et al.  Morphometry in differential diagnosis of pathologically altered parathyroid glands: adenoma and hyperplasia. , 2012, Collegium antropologicum.

[8]  P. Dey,et al.  Image cytometry of insular carcinoma , 2012, Diagnostic cytopathology.

[9]  Helen H. Wang,et al.  Eliminating the "Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance" category from the Bethesda System for Reporting Thyroid Cytopathology. , 2011, American journal of clinical pathology.

[10]  S. Sundaram,et al.  Morphology to morphometry in cytological evaluation of thyroid lesions , 2011, Journal of cytology.

[11]  E. Marqusee,et al.  Clinical outcome for atypia of undetermined significance in thyroid fine-needle aspirations: should repeated fna be the preferred initial approach? , 2011, American journal of clinical pathology.

[12]  D. Babić,et al.  Digital morphometry of cytologic aspirate endometrial samples. , 2010, Collegium antropologicum.

[13]  J. Jakić-Razumović,et al.  Morphometry of tumor cells in different grades and types of breast cancer. , 2010, Collegium antropologicum.

[14]  E. Cibas,et al.  The Bethesda System for Reporting Thyroid Cytopathology , 2009, Springer International Publishing.

[15]  C. Chai,et al.  Diagnostic Value of Computerized Nuclear Morphometry for the Prediction of Malignancy in Liver Fine Needle Aspiration Cytology , 2009, Acta Cytologica.

[16]  Jack Yang,et al.  Fine‐needle aspiration of thyroid nodules: A study of 4703 patients with histologic and clinical correlations , 2007, Cancer.

[17]  K. Kapila,et al.  Fine needle aspiration cytology: a survey of current European practice , 2006, Cytopathology : official journal of the British Society for Clinical Cytology.

[18]  P. Dey,et al.  Fine Needle Aspiration Cytology of the Thyroid , 2005, Acta Cytologica.

[19]  H. Harms,et al.  Computer-based cytophotometric classification of thyroid tumors in imprints , 2004, Journal of Cancer Research and Clinical Oncology.

[20]  P. Dey,et al.  Nuclear image morphometry and cytologic grade of breast carcinoma. , 2000, Analytical and quantitative cytology and histology.

[21]  P Davaris,et al.  Computerized morphometric study on fine needle aspirates of cellular follicular lesions of the thyroid. , 2000, Analytical and quantitative cytology and histology.

[22]  Takeshi Nagashima,et al.  Morphometry in the cytologic evaluation of thyroid follicular lesions , 1998, Cancer.

[23]  M. Suzuki,et al.  Cytologic morphometric approach for the prediction of lymph node involvement in papillary thyroid cancer. , 1997, Analytical and quantitative cytology and histology.

[24]  H. Gharib,et al.  Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations, and effect. , 1994, Mayo Clinic proceedings.

[25]  R. G. Wright,et al.  Morphometric analysis of thyroid cell aspirates. , 1987, Journal of clinical pathology.

[26]  F. Hawkins,et al.  Fine needle aspiration biopsy in the diagnosis of thyroid cancer and thyroid disease , 1987, Cancer.