Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

[1]  F. Alt,et al.  Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells. , 1997, Immunity.

[2]  F. Melchers.  Lymphoid development. , 1997, Research in immunology.

[3]  P. Morrissey,et al.  Impaired survival and proliferation in IL-7 receptor-deficient peripheral T cells. , 1996, Journal of immunology.

[4]  A. Strasser,et al.  The cell death inhibitor Bcl‐2 and its homologues influence control of cell cycle entry. , 1996, The EMBO journal.

[5]  G. Linette,et al.  Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[6]  M. Raff,et al.  Size Control: The Regulation of Cell Numbers in Animal Development , 1996, Cell.

[7]  K. Rajewsky.  Clonal selection and learning in the antibody system , 1996, Nature.

[8]  H. Petrie,et al.  Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death , 1996, The Journal of experimental medicine.

[9]  Li Wu,et al.  Early T lymphocyte progenitors. , 1996, Annual review of immunology.

[10]  A. Strasser,et al.  Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis. , 1995, The EMBO journal.

[11]  M. Moreno,et al.  Bcl-2 blocks glucocorticoid- but not Fas- or activation-induced apoptosis in a T cell hybridoma. , 1995, Journal of immunology.

[12]  P. Doherty,et al.  Defective Lymphoid Development in Mice Lacking Jak3 , 1995, Science.

[13]  W. Swat,et al.  Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. , 1995, Immunity.

[14]  S. Goff,et al.  Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors. , 1995, Immunity.

[15]  H. Fehling,et al.  Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells , 1995, Nature.

[16]  C. Pénit,et al.  Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. , 1995, Journal of immunology.

[17]  S. Burdach,et al.  Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine , 1995, The Journal of experimental medicine.

[18]  C. Bunce,et al.  Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential. , 1995, International immunology.

[19]  W. Leonard,et al.  Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. , 1995, Immunity.

[20]  S. Korsmeyer.  Regulators of cell death. , 1995, Trends in genetics : TIG.

[21]  S. Cory.  Regulation of lymphocyte survival by the bcl-2 gene family. , 1995, Annual review of immunology.

[22]  J. Sprent,et al.  T-cell apoptosis detected in situ during positive and negative selection in the thymus , 1994, Nature.

[23]  C. Ware,et al.  Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice , 1994, The Journal of experimental medicine.

[24]  G. Linette,et al.  Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. , 1994, Immunity.

[25]  D. Baltimore,et al.  Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. , 1994, Genes & development.

[26]  A. Strasser,et al.  Bcl-2 expression promotes B- but not T-lymphoid development in scid mice , 1994, Nature.

[27]  S. Nishikawa,et al.  Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes. , 1994, Science.

[28]  A. Strasser,et al.  Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[29]  H. Boehmer.  Positive selection of lymphocytes , 1994, Cell.

[30]  G. J. V. Nossal,et al.  Negative selection of lymphocytes , 1994, Cell.

[31]  A. Basten,et al.  Reduced life span of anergic self-reactive B cells in a double- transgenic model , 1994, The Journal of experimental medicine.

[32]  H. von Boehmer.  Positive selection of lymphocytes. , 1994, Cell.

[33]  S. Ziegler,et al.  Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. , 1993, Science.

[34]  A. Zlotnik,et al.  Control points in early T-cell development. , 1993, Immunology today.

[35]  A. Hayday,et al.  A novel disulfide-linked heterodimer on pre—T cells consists of the T cell receptor β chain and a 33 kd glycoprotein , 1993, Cell.

[36]  A. Strasser,et al.  Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci , 1993, The Journal of experimental medicine.

[37]  S. Nishikawa,et al.  Expression and function of the interleukin 7 receptor in murine lymphocytes. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[38]  S. Korsmeyer,et al.  Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes. , 1993, Journal of immunology.

[39]  D. Schatz,et al.  Multiple rearrangements in T cell receptor alpha chain genes maximize the production of useful thymocytes , 1993, The Journal of experimental medicine.

[40]  K. Muegge,et al.  Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene. , 1993, Science.

[41]  F. Finkelman,et al.  Inhibition of murine B and T lymphopoiesis in vivo by an anti- interleukin 7 monoclonal antibody , 1993, The Journal of experimental medicine.

[42]  W. Fiers,et al.  Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. , 1993, Oncogene.

[43]  P. Leder,et al.  Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice , 1993, The Journal of experimental medicine.

[44]  S. Tonegawa,et al.  Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages , 1992, Nature.

[45]  A. Zlotnik,et al.  Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. , 1992, Journal of immunology.

[46]  S. Rastan,et al.  Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cells. , 1992, Science.

[47]  A. Wakeham,et al.  Profound block in thymocyte development in mice lacking p56lck , 1992, Nature.

[48]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[49]  V. Stewart,et al.  RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement , 1992, Cell.

[50]  Suzanne Cory,et al.  bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship , 1991, Cell.

[51]  S. Korsmeyer,et al.  bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes , 1991, Cell.

[52]  P. Morrissey,et al.  Administration of IL-7 to normal mice stimulates B-lymphopoiesis and peripheral lymphadenopathy. , 1991, Journal of immunology.

[53]  G. Casorati,et al.  Development of lymphocytes in interleukin 7‐transgenic mice , 1991, European journal of immunology.

[54]  A. Heimberger,et al.  Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo. , 1990, Science.

[55]  M. Egerton,et al.  The kinetics of immature murine thymocyte development in vivo. , 1990, International immunology.

[56]  A. Zlotnik,et al.  IL-7 is a growth and maintenance factor for mature and immature thymocyte subsets. , 1989, International immunology.

[57]  K. Rajewsky,et al.  Flow cytometric analysis of cell proliferation dynamics in the B cell compartment of the mouse. , 1989, International immunology.

[58]  D. Metcalf,et al.  The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells , 1989, Nature.

[59]  S. Reed,et al.  Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells , 1989, The Journal of experimental medicine.

[60]  R. Goodwin,et al.  Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[61]  C. March,et al.  Stimulation of B-cell progenitors by cloned murine interleukin-7 , 1988, Nature.