Relation between local cure and dose-time-volume factors in interstitial implants.

The dose and volume data of 119 patients treated with radium or iridium-192 implants for cancer of the tongue, bladder or perineum are presented. The computer dosimetry system used in the Antoni van Leeuwenhoek Hospital permitted analysis of data regarding treated volume, dose variation inside the treated volume, patterns of geographical defects and their impact on the result of treatment. Dose was expressed in a number of ways, including prescribed (reference) and average dose and the CRE (Cumulative Radiation Effect) level attained. The CRE value included a time correction and a volume correction. The average dose proved to be the best predictor of local result in case of tongue and perineal implants. Great care is needed in case of tongue carcinoma to avoid a geographical miss by an inadequate treatment volume or geometric defects. The hypothesis that a dose reduction factor is necessary, in case of a high dose rate, could not be validated.

[1]  W. Hop,et al.  Cancer of the urinary bladder category T2, T3, (NxMo) treated by interstitial radium implant: second report. , 1983, International journal of radiation oncology, biology, physics.

[2]  W. M. Gray,et al.  Cumulative radiation effect. Part VI: simple nomographic and tabular methods for the solution of practical problems. , 1977, Clinical radiology.

[3]  F. Ellis,et al.  A method of estimating biological effect of combined intracavitary low dose rate radiation with external radiation in carcinoma of the cervix uteri. , 1974, Radiology.

[4]  H. Awwad,et al.  CELL PROLIFERATION OF CARCINOMA IN BILHARZIAL BLADDER: AN AUTORADIOGRAPHIC STUDY , 1979, Cell and tissue kinetics.

[5]  S. Cade,et al.  Cancer of the tongue a study based on 653 patients , 1957 .

[6]  H. Awwad,et al.  The influence of tumor dose specification on the early clinical results of interstitial radium tongue implants. , 1974, Radiology.

[7]  F. Baillet,et al.  Clinical observations on the time factor in interstitial radiotherapy using iridium-192. , 1973, Clinical radiology.

[8]  H. Awwad,et al.  Studies in dose-time-volume relationships in bladder and tongue radium implants. , 1976, Clinical radiology.

[9]  David R. Cox.  The analysis of binary data , 1970 .

[10]  W. M. Gray,et al.  Cumulative radiation effect. part IV. Normalisation of fractionated and continuous therapy - area and volume correction factors. , 1975, Clinical radiology.

[11]  M. Friedman.  The biological and clinical basis of radiosensitivity , 1974 .

[12]  J. Bedford,et al.  Dose-rate effects in synchronous mammalian cells in culture. , 1973, Radiation research.

[13]  R. Paterson.  The treatment of malignant disease by radium and X-Rays : being a practice of radiotherapy , 1948 .

[14]  C G Orton,et al.  Time-dose factors (TDFs) in brachytherapy. , 1974, The British journal of radiology.

[15]  F. Ellis.  RELATIONSHIP OF BIOLOGICAL EFFECT TO DOSE-TIME-FRACTIONATION FACTORS IN RADIOTHERAPY. , 1968 .

[16]  T. K. Hunt,et al.  Wound healing and wound infection : theory and surgical practice , 1980 .

[17]  W. M. Gray,et al.  Cumulative radiation effect part I: Fractionated treatment regimes , 1971 .

[18]  A Dutreix,et al.  The Paris system in interstitial radiation therapy. , 1978, Acta radiologica: oncology, radiation, physics, biology.