Facile and large-scale synthesis of Gd(OH)3 nanorods for MR imaging with low toxicity

We report the facile and scalable synthesis of a highly monodispersed inorganic nanostructure based on well-designed Gd(OH)3 nanorods. X-Ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), as well as energy-dispersive spectroscopy (EDS) were applied to characterize the samples, indicating that the nanomaterials with an average length of 100 nm and an average diameter of 15 nm showed a typical hexagonal phase. Biocompatibility tests were performed from in vitro cell experiments to in vivo long-term histological assessment, indicating that the Gd(OH)3 nanorods were promising for further bio-related application. Owing to the excellent paramagnetic behavior, we further investigated the capability of the nanorods as MRI contrast agent. Compared with the conventional Gd–DTPA complex, the well-designed Gd(OH)3 nanorods present a higher T1 relaxation rate, showing more potential for biomedicine applications.

[1]  Dwight G Nishimura,et al.  FeCo/graphitic-shell nanocrystals as advanced magnetic-resonance-imaging and near-infrared agents , 2006, Nature materials.

[2]  P. Perriat,et al.  Hybrid gadolinium oxide nanoparticles: multimodal contrast agents for in vivo imaging. , 2007, Journal of the American Chemical Society.

[3]  Probing cytotoxicity of gadolinium hydroxide nanostructures. , 2010, The journal of physical chemistry. B.

[4]  Forrest M Kievit,et al.  Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery. , 2011, Biomaterials.

[5]  Chun-Hua Yan,et al.  Biocompatible Bright YVO4:Eu Nanoparticles as Versatile Optical Bioprobes , 2010 .

[6]  Jinyoung Hwang,et al.  Bioinspired synthesis and characterization of gadolinium-labeled magnetite nanoparticles for dual contrast t1- and T2-weighted magnetic resonance imaging. , 2010, Bioconjugate chemistry.

[7]  Yongmin Chang,et al.  Paramagnetic ultrasmall gadolinium oxide nanoparticles as advanced T1 MRI contrast agent: account for large longitudinal relaxivity, optimal particle diameter, and in vivo T1 MR images. , 2009, ACS nano.

[8]  R. Weissleder,et al.  Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method. , 2011, Angewandte Chemie.

[9]  Hakho Lee,et al.  Ultrasensitive detection of bacteria using core-shell nanoparticles and an NMR-filter system. , 2009, Angewandte Chemie.

[10]  V. Yang,et al.  Magnetically-enabled and MR-monitored selective brain tumor protein delivery in rats via magnetic nanocarriers. , 2011, Biomaterials.

[11]  J. Cheon,et al.  Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. , 2008, Accounts of chemical research.

[12]  Jianlin Shi,et al.  Fe3O4 core/layered double hydroxide shell nanocomposite: versatile magnetic matrix for anionic functional materials. , 2009, Angewandte Chemie.

[13]  Taeghwan Hyeon,et al.  Wrap-bake-peel process for nanostructural transformation from beta-FeOOH nanorods to biocompatible iron oxide nanocapsules. , 2008, Nature materials.

[14]  Jinwoo Cheon,et al.  Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. , 2008, Angewandte Chemie.

[15]  Cédric Louis,et al.  Biodistribution study of nanometric hybrid gadolinium oxide particles as a multimodal SPECT/MR/optical imaging and theragnostic agent. , 2011, Bioconjugate chemistry.

[16]  Lehui Lu,et al.  Fluorescence-enhanced gadolinium-doped zinc oxide quantum dots for magnetic resonance and fluorescence imaging. , 2011, Biomaterials.

[17]  T. Ichihashi,et al.  Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels. , 2009, ACS nano.

[18]  Taeghwan Hyeon,et al.  Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy. , 2009, Chemical Society reviews.

[19]  Kuo-Wei Hu,et al.  pH-Dependent biodegradable silica nanotubes derived from Gd(OH)3 nanorods and their potential for oral drug delivery and MR imaging. , 2010, Biomaterials.

[20]  Yang Yang,et al.  Long-term in vivo biodistribution imaging and toxicity of polyacrylic acid-coated upconversion nanophosphors. , 2010, Biomaterials.

[21]  Zhichuan J. Xu,et al.  Synthesis, Functionalization, and Biomedical Applications of Multifunctional Magnetic Nanoparticles , 2010, Advanced materials.

[22]  Jin Wu,et al.  The photoluminescence, drug delivery and imaging properties of multifunctional Eu3+/Gd3+ dual-doped hydroxyapatite nanorods. , 2011, Biomaterials.

[23]  Fong-Yu Cheng,et al.  Enhancing transversal relaxation for magnetite nanoparticles in MR imaging using Gd³+- chelated mesoporous silica shells. , 2011, ACS nano.

[24]  Jinwoo Cheon,et al.  Synergistically integrated nanoparticles as multimodal probes for nanobiotechnology. , 2008, Accounts of chemical research.

[25]  Yun Sun,et al.  Fluorine-18-labeled Gd3+/Yb3+/Er3+ co-doped NaYF4 nanophosphors for multimodality PET/MR/UCL imaging. , 2011, Biomaterials.

[26]  Weili Lin,et al.  Hybrid silica nanoparticles for multimodal imaging. , 2007, Angewandte Chemie.

[27]  D. Mao,et al.  Thermal dehydration kinetics of a rare earth hydroxide, Gd(OH)3 , 2007 .

[28]  Xiaogang Liu,et al.  Emerging functional nanomaterials for therapeutics , 2011 .

[29]  Kai Yang,et al.  Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dual-targeted photothermal therapy. , 2011, Angewandte Chemie.

[30]  X. Qu,et al.  Luminescent Rare-Earth Complex Covalently Modified Single-Walled Carbon Nanotubes: Design, Synthesis, and DNA Sequence-Dependent Red Luminescence Enhancement , 2010 .

[31]  H. Sheu,et al.  Gd2O(CO3)2 · H2O Particles and the Corresponding Gd2O3: Synthesis and Applications of Magnetic Resonance Contrast Agents and Template Particles for Hollow Spheres and Hybrid Composites , 2008 .