Teratogenic phthalate esters and metabolites activate the nuclear receptors PPARs and induce differentiation of F9 cells.
暂无分享,去创建一个
[1] H. Nau,et al. Prediction of embryotoxic effects of valproic acid-derivatives with molecular in vitro methods. , 2001, ALTEX.
[2] D. Noonan,et al. Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators , 1994, The Journal of Steroid Biochemistry and Molecular Biology.
[3] M. Ema,et al. Developmental toxicity of mono-n-benzyl phthalate, one of the major metabolites of the plasticizer n-butyl benzyl phthalate, in rats. , 1996, Toxicology letters.
[4] Barry M. Forman,et al. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ , 1997 .
[5] C. Elcombe,et al. Identification of the proximate peroxisome proliferator(s) derived from di (2-ethylhexyl) adipate and species differences in response. , 1992, Biochemical pharmacology.
[6] Developmental toxicity evaluation of dietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice. , 1988 .
[7] W. Wahli,et al. Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. , 1997, Molecular endocrinology.
[8] K. Griffin,et al. Peroxisome proliferator activated receptor-alpha expression in human liver. , 1998, Molecular pharmacology.
[9] R. Clark. The role of PPARs in inflammation and immunity , 2002, Journal of leukocyte biology.
[10] T. Pineau,et al. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators , 1995, Molecular and cellular biology.
[11] J. Auwerx,et al. Peroxisome proliferator-activated receptors, orphans with ligands and functions. , 1997, Current opinion in lipidology.
[12] H Nau,et al. New molecular bioassays for the estimation of the teratogenic potency of valproic acid derivatives in vitro: activation of the peroxisomal proliferator-activated receptor (PPARdelta). , 1999, Toxicology and applied pharmacology.
[13] H. Nau,et al. Peroxisome proliferator-activated receptor delta is a specific sensor for teratogenic valproic acid derivatives. , 2001, European journal of pharmacology.
[14] A. Saillenfait,et al. Effects of Mono‐n‐butyl Phthalate on the Development of Rat Embryos: In vivo and in vitro Observations , 2001 .
[15] J M Ward,et al. Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice , 1998, Toxicologic pathology.
[16] K. Wood,et al. Firefly luciferase gene: structure and expression in mammalian cells , 1987, Molecular and cellular biology.
[17] M. Sleigh. Differential regulation of viral and cellular genes in F9 mouse embryonal carcinoma cells. , 1987, Nucleic Acids Research.
[18] Kathleen N. Smith,et al. Evaluation of 60 chemicals in a preliminary developmental toxicity test. , 1987, Teratogenesis, carcinogenesis, and mutagenesis.
[19] P Fenner-Crisp,et al. Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans? , 1998, Regulatory toxicology and pharmacology : RTP.
[20] P. Albro,et al. Mono-2-ethylhexyl phthalate, a metabolite of di-(2-ethylhexyl) phthalate, causally linked to testicular atrophy in rats. , 1989, Toxicology and applied pharmacology.
[21] W. Scott,et al. Teratogenicity of di(2-ethylhexyl) phthalate, 2-ethylhexanol, 2-ethylhexanoic acid, and valproic acid, and potentiation by caffeine. , 1987, Teratology.
[22] P. Dartsch,et al. Nephrotoxic effects of di-(2-ethylhexyl)phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells , 1998, Human & experimental toxicology.
[23] M. Guenther,et al. Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen* , 2001, The Journal of Biological Chemistry.
[24] H. Nau,et al. Asymmetric synthesis and teratogenic activity of (R)- and (S)-2-ethylhexanoic acid, a metabolite of the plasticizer di-(2-ethylhexyl)phthalate. , 1990, Life sciences.
[25] K. Kinzler,et al. PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs , 1999, Cell.
[26] E. Wagner,et al. The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. , 1996, Nucleic acids research.
[27] K. Shiota,et al. Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice. , 1982, Environmental health perspectives.
[28] C. Price,et al. Developmental toxicity evaluation of diethyl and dimethyl phthalate in rats. , 1993, Teratology.
[29] K. Umesono,et al. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[30] Fetotoxic effects of mono-2-ethylhexyl phthalate (MEHP) in mice. , 1986 .
[31] I. Issemann,et al. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators , 1990, Nature.
[32] Peter J. Brown,et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ , 1997 .
[33] C. Keen,et al. Effect of butyl benzyl phthalate on reproduction and zinc metabolism. , 2001, Toxicology.
[34] Ping Zhu,et al. Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells , 2001, The EMBO journal.
[35] David J. Waxman,et al. trans-activation of PPARα and PPARγ by structurally diverse environmental chemicals , 1999 .
[36] I. Issemann,et al. The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs. , 1993, Journal of molecular endocrinology.
[37] H. Nau,et al. Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity. , 1992, Teratology.
[38] H. Nau,et al. Exposure of newborn infants to di‐(2‐ethylhexyl)‐phthalate and 2‐ ethylhexanoic acid following exchange transfusion with polyvinylchloride catheters , 1993, Transfusion.
[39] J. Lehmann,et al. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. , 2000, Molecular cell.
[40] H. Nau,et al. Induction of differentiation in F9 cells and activation of peroxisome proliferator-activated receptor delta by valproic acid and its teratogenic derivatives. , 2001, Molecular pharmacology.
[41] J. Gustafsson,et al. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[42] D. Keppler,et al. Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome-proliferators-activated receptor (PPAR). , 1996, European journal of biochemistry.
[43] P. Albro,et al. Metabolism of di(2-ethylhexyl)phthalate. , 1989, Drug metabolism reviews.
[44] W. Wahli,et al. PPARα Structure-Function Relationships Derived from Species-Specific Differences in Responsiveness to Hypolipidemic Agents , 1997, Biological chemistry.
[45] R. Melnick,et al. Studies By the National Toxicology Program On Di(2-Ethylhexyl)Phthalate , 1987, Toxicology and industrial health.
[46] O. Kellermann,et al. Immortalization of precursors of endodermal, neuroectodermal and mesodermal lineages, following the introduction of the simian virus (SV40) early region into F9 cells. , 1987, Differentiation; research in biological diversity.
[47] R. Schulte‐Hermann,et al. Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk. , 1996, Critical reviews in toxicology.
[48] T. Willson,et al. Peroxisome proliferator activated receptor agonists. , 1997, EXS.