Drowsy Driving Among Older Adults: A Literature Review

2 Disclaimer The contents of this report reflect the views of the authors, who are responsible for the facts and the accuracy of the information presented herein. This document is disseminated under the sponsorship of the Department of Transportation's University Transportation Centers Program, in the interest of information exchange. The U.S. Government assumes no liability for the contents or use thereof. The order of the last five authors is in alphabetical order. The goals of this literature review are to better understand the risk factors associated with drowsy driving, particularly those strongly affecting the older driver population, and to serve as the background information for the development of a questionnaire on this topic. The review is divided into two main sections: drowsy driving risk factors and countermeasures. Topics reviewed in the risk factors section include: sleep deprivation and disorders, medications that may cause drowsiness as a side effect, work schedules, circadian rhythm, personality attributes, alcohol use, lifestyle, and environmental characteristics. Topics reviewed in the countermeasures section included: common practices (e.g. turning up the volume of the radio), caffeine, napping, sleep disorder treatments, lifestyle, work schedules, alertness maintenance and in-vehicle technology. Emphasis was placed on finding studies performed on older drivers, although studies done on younger or middle-aged drivers were not excluded. Sleep disorders and various medical conditions and medications that may cause drowsiness are prevalent in the older population, putting older drivers at an increased risk of a drowsy driving crash. The circadian rhythm creates a risk for those driving between the hours of midnight and 6:00 AM and again in the mid-afternoon. Unusual work schedules, certain personality traits, alcohol use, and lifestyle practices (e.g. smoking) and monotonous road conditions may all lead to driver sleepiness and crash risk. Common practices to combat drowsy driving such as rolling down a window or turning up the radio's volume are not effective in combating drowsiness. Caffeine intake may help alleviate sleepiness, especially if combined with a short nap. Many non-medication treatments may benefit older adults suffering from sleep disorders or problems, but more research is needed to ascertain whether these treatments increase driving safety. Numerous types of in-vehicle drowsiness-detection technology have been developed to alert drivers before they crash. Overall, more research is needed to further understand drowsy driving risk factors and countermeasures regarding drivers age 65 and older. Findings indicated a strong need for more research on older drivers' crash risk …

[1]  S J Williams THE ACCIDENT-PRONE DRIVER , 1931 .

[2]  J. G. Perry,et al.  DRUGS AND DRIVING , 1980 .

[3]  M J Mattila,et al.  Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving , 1975, Clinical pharmacology and therapeutics.

[4]  B Roth,et al.  Life Effects of Narcolepsy in 180 Patients from North America, Asia and Europe Compared to Matched Controls , 1981, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[5]  A Smiley,et al.  Effects of chronically administered buspirone and diazepam on driving-related skills performance. , 1982, The Journal of clinical psychiatry.

[6]  J F O'Hanlon,et al.  Diazepam impairs lateral position control in highway driving. , 1982, Science.

[7]  T. Betts,et al.  Effects of two antihistamine drugs on actual driving performance. , 1984, British medical journal.

[8]  Karel Brookhuis,et al.  The effects of the antidepressants oxaprotiline, mianserin, amitryptiline and doxepin upon actual driving performance , 1984 .

[9]  L. Judd,et al.  The effect of antipsychotic drugs on driving and driving related psychomotor functions. , 1985, Accident; analysis and prevention.

[10]  B. Stone,et al.  Hypnotics and transient insomnia , 1986, Acta psychiatrica Scandinavica. Supplementum.

[11]  A Smiley,et al.  Effects of minor tranquilizers and antidepressants on psychomotor performance. , 1987, The Journal of clinical psychiatry.

[12]  J. Haze,et al.  Obstructive sleep apnea. , 1987, Cranio : the journal of craniomandibular practice.

[13]  M. Kryger,et al.  SLEEP APNOEA PATIENTS HAVE MORE AUTOMOBILE ACCIDENTS , 1987, The Lancet.

[14]  L. Findley,et al.  Automobile accidents involving patients with obstructive sleep apnea. , 1988, The American review of respiratory disease.

[15]  I Hindmarch,et al.  The psychopharmacological approach: effects of psychotropic drugs on car handling. , 1988, International clinical psychopharmacology.

[16]  R T Wilkinson,et al.  The detection of sleep onset: behavioral, physiological, and subjective convergence. , 1989, Sleep.

[17]  M. Aldrich Automobile accidents in patients with sleep disorders. , 1989, Sleep.

[18]  F. Gengo,et al.  The pharmacodynamics of diphenhydramine‐induced drowsiness and changes in mental performance , 1989, Clinical pharmacology and therapeutics.

[19]  P. Haraldsson,et al.  Clinical symptoms of sleep apnea syndrome and automobile accidents. , 1990, ORL; journal for oto-rhino-laryngology and its related specialties.

[20]  J A Horne,et al.  Time-of-day effects of alcohol intake on simulated driving performance in women. , 1991, Ergonomics.

[21]  J. Gfeller,et al.  A Double-Blind Comparison of the Effects of Temazepam and Triazolam on Residual, Daytime Performance in Elderly Insomniacs , 1992, International Psychogeriatrics.

[22]  W A Ray,et al.  Psychoactive drugs and the risk of injurious motor vehicle crashes in elderly drivers. , 1992, American journal of epidemiology.

[23]  J. O'Hanlon Discussion of “Medications and the Safety of the Older Driver” by Ray et al. , 1992 .

[24]  W A Ray,et al.  Medications and the older driver. , 1993, Clinics in geriatric medicine.

[25]  H. Wildgust,et al.  Effects of depot neuroleptics on driving performance in chronic schizophrenic patients. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[26]  Andrew P. Smith,et al.  Effects of sleep deprivation, lunch, and personality on performance, mood, and cardiovascular function , 1993, Physiology & Behavior.

[27]  Suzanne G. Leveille,et al.  Psychoactive Medications and Injurious Motor Vehicle Collisions Involving Older Drivers , 1994, Epidemiology.

[28]  H Summala,et al.  Fatal Accidents among Car and Truck Drivers: Effects of Fatigue, Age, and Alcohol Consumption , 1994, Human factors.

[29]  T. Roth,et al.  Sleepiness and ethanol effects on simulated driving. , 1994, Alcoholism, clinical and experimental research.

[30]  Robert D. Peters,et al.  Effects of Partial and Total Sleep Deprivation on Driving Performance , 1995 .

[31]  L. Findley,et al.  Vigilance and automobile accidents in patients with sleep apnea or narcolepsy. , 1995, Chest.

[32]  D J Foley,et al.  Sleep complaints among elderly persons: an epidemiologic study of three communities. , 1995, Sleep.

[33]  C. Cook,et al.  Sleep related vehicle accidents , 1995, BMJ.

[34]  Andrew M. Pack,et al.  Characteristics of crashes attributed to the driver having fallen asleep. , 1995, Accident; analysis and prevention.

[35]  C. I. Neutel,et al.  Risk of traffic accident injury after a prescription for a benzodiazepine. , 1995, Annals of epidemiology.

[36]  C. Marcus,et al.  Effect of sleep deprivation on driving safety in housestaff. , 1996, Sleep.

[37]  Han Wu,et al.  Self‐reported automobile accidents involving patients with obstructive sleep apnea , 1996, Neurology.

[38]  A T McCartt,et al.  The scope and nature of the drowsy driving problem in New York State. , 1995, Accident; analysis and prevention.

[39]  C. Guilleminault,et al.  Determinants of sleepiness in automobile drivers. , 1996, Journal of psychosomatic research.

[40]  A. King,et al.  Moderate-Intensity Exercise and Self-rated Quality of Sleep in Older Adults: A Randomized Controlled Trial , 1997 .

[41]  Thomas A. Dingus,et al.  Effects of Age, System Experience, and Navigation Technique on Driving with an Advanced Traveler Information System , 1997, Hum. Factors.

[42]  T. Roth,et al.  The alerting effects of short and long naps in narcoleptic, sleep deprived, and alert individuals. , 1997, Sleep.

[43]  C. Guilleminault,et al.  Objective measurement of sleepiness in summer vacation long-distance drivers. , 1997, Electroencephalography and clinical neurophysiology.

[44]  A Smiley,et al.  Effects of nasal CPAP on simulated driving performance in patients with obstructive sleep apnoea. , 1997, Thorax.

[45]  G Maycock,et al.  Sleepiness and driving: the experience of heavy goods vehicle drivers in the UK , 1997, Journal of sleep research.

[46]  J. Horne,et al.  Suppression of sleepiness in drivers: combination of caffeine with a short nap. , 1997, Psychophysiology.

[47]  C. Guilleminault,et al.  How sleep and mental disorders are related to complaints of daytime sleepiness. , 1997, Archives of internal medicine.

[48]  B. Hemmelgarn,et al.  Benzodiazepine use and the risk of motor vehicle crash in the elderly. , 1997, JAMA.

[49]  G Berghaus,et al.  CONCENTRATION-EFFECT RELATIONSHIP WITH BENZODIAZEPINE THERAPY , 1997 .

[50]  David F. Dinges,et al.  Changing Behaviors to Prevent Drowsy Driving and Promote Traffic Safety: Review of Proven, Promising, and Unproven Techniques , 1998 .

[51]  E. Bixler,et al.  Obesity without sleep apnea is associated with daytime sleepiness. , 1998, Archives of internal medicine.

[52]  J. Horne,et al.  Evaluation "in-car" countermeasures to sleepiness: cold air and radio. , 1998, Sleep.

[53]  L. Findley,et al.  Automobile accidents in patients with sleep apnea syndrome. An epidemiological and mechanistic study. , 1998, American journal of respiratory and critical care medicine.

[54]  L. Findley,et al.  Time-on-task decrements in "steer clear" performance of patients with sleep apnea and narcolepsy. , 1999, Sleep.

[55]  W B Verwey,et al.  Preventing drowsiness accidents by an alertness maintenance device. , 1999, Accident; analysis and prevention.

[56]  Stephen H. Fairclough,et al.  Impairment of Driving Performance Caused by Sleep Deprivation or Alcohol: A Comparative Study , 1999, Hum. Factors.

[57]  K. Nokes,et al.  Exploring the complexity of sleep disturbances in persons with HIV/AIDS. , 1999, The Journal of the Association of Nurses in AIDS Care : JANAC.

[58]  J. Horne,et al.  Vehicle accidents related to sleep: a review. , 1999, Occupational and environmental medicine.

[59]  D. Neubauer,et al.  Sleep problems in the elderly. , 1999, American family physician.

[60]  A. Williamson,et al.  Moderate sleep deprivation produces impairments in cognitive and motor performance equivalent to legally prescribed levels of alcohol intoxication , 2000, Occupational and environmental medicine.

[61]  Willem B. Verwey,et al.  Predicting drowsiness accidents from personal attributes, eye blinks and ongoing driving behaviour , 2000 .

[62]  A T McCartt,et al.  Factors associated with falling asleep at the wheel among long-distance truck drivers. , 2000, Accident; analysis and prevention.

[63]  K. Ball,et al.  Exploratory study of incident vehicle crashes among older drivers. , 2000, The journals of gerontology. Series A, Biological sciences and medical sciences.

[64]  Munt,et al.  Simulated driving performance following prolonged wakefulness and alcohol consumption: separate and combined contributions to impairment , 2000, Journal of sleep research.

[65]  R. Sims,et al.  Relations among chronic medical conditions, medications, and automobile crashes in the elderly: a population-based case-control study. , 2000, American journal of epidemiology.

[66]  R. Chervin,et al.  Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea. , 2000, Chest.

[67]  C. Bassetti,et al.  Sleepiness-related accidents in sleep apnea patients. , 2000, Sleep.

[68]  J. Horne,et al.  Early morning driver sleepiness: effectiveness of 200 mg caffeine. , 2000, Psychophysiology.

[69]  P M Suratt,et al.  Treatment with nasal CPAP decreases automobile accidents in patients with sleep apnea. , 2000, American journal of respiratory and critical care medicine.

[70]  Tim Horberry,et al.  REVIEW OF FATIGUE DETECTION AND PREDICTION TECHNOLOGIES , 2000 .

[71]  W. Oertel,et al.  Safety of pramipexole in patients with restless legs syndrome , 2000, Neurology.

[72]  R Cluydts,et al.  Slow‐release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation , 2001, Journal of sleep research.

[73]  A. Maclean,et al.  How do prolonged wakefulness and alcohol compare in the decrements they produce on a simulated driving task? , 2001, Accident; analysis and prevention.

[74]  J. Robinson,et al.  Caffeine antagonism of alcohol-induced driving impairment. , 2001, Drug and alcohol dependence.

[75]  J A Caldwell,et al.  The impact of fatigue in air medical and other types of operations: a review of fatigue facts and potential countermeasures. , 2001, Air medical journal.

[76]  A. Rogers,et al.  A comparison of three different sleep schedules for reducing daytime sleepiness in narcolepsy. , 2001, Sleep.

[77]  J. Horne,et al.  Beneficial effects of an "energy drink" given to sleepy drivers , 2001, Amino Acids.

[78]  Joseph F. Coughlin,et al.  Older and Younger Drivers' Reliance on Collision Warning Systems , 2001 .

[79]  C. Guilleminault,et al.  The Road to Danger: The Comparative Risks of Driving While Sleepy , 2001, The Laryngoscope.

[80]  Rika Hasegawa,et al.  Falling asleep while driving and automobile accidents among patients with obstructive sleep apnea–hypopnea syndrome , 2002, Psychiatry and clinical neurosciences.

[81]  C. N. Homann,et al.  Experience, competency, and education: Graduating neurology residents’ experience with tPA , 2001, Neurology.

[82]  R. Norton,et al.  Driver sleepiness and risk of serious injury to car occupants: population based case control study , 2002, BMJ : British Medical Journal.

[83]  Ziad Boulos,et al.  Effects of an afternoon nap on nighttime alertness and performance in long-haul drivers. , 2002, Accident; analysis and prevention.

[84]  D Shinar,et al.  STATE OF KNOWLEDGE OF DRUG-IMPAIRED DRIVING , 2003 .

[85]  D Royal National survey of distracted and drowsy driving attitudes and behaviors: 2002: volume 1: findings report , 2003 .

[86]  C. Bourguignon,et al.  Investigating Sleep Disturbances in Adults With Rheumatoid Arthritis , 2003, Holistic nursing practice.

[87]  Jane C Stutts,et al.  Driver risk factors for sleep-related crashes. , 2003, Accident; analysis and prevention.

[88]  Jacques Bergeron,et al.  Monotony of road environment and driver fatigue: a simulator study. , 2003, Accident; analysis and prevention.

[89]  L A Reyner,et al.  Driving impairment due to sleepiness is exacerbated by low alcohol intake , 2003, Occupational and environmental medicine.

[90]  M Partinen,et al.  Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia. , 2003, Sleep medicine.

[91]  J. Bergeron,et al.  Fatigue and individual differences in monotonous simulated driving , 2003 .

[92]  J. Ramaekers Antidepressants and driver impairment: empirical evidence from a standard on-the-road test. , 2003, The Journal of clinical psychiatry.

[93]  M. Hayashi,et al.  The alerting effects of caffeine, bright light and face washing after a short daytime nap , 2003, Clinical Neurophysiology.

[94]  Joris C Verster,et al.  Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. , 2004, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[95]  B. Bioulac,et al.  Age, performance and sleep deprivation , 2004, Journal of sleep research.

[96]  J. Malin,et al.  Comparison of driving simulator performance and neuropsychological testing in Narcolepsy , 2004, Clinical Neurology and Neurosurgery.

[97]  C. Guilleminault,et al.  Twenty minutes versus forty-five minutes morning bright light treatment on sleep onset insomnia in elderly subjects. , 2004, Journal of psychosomatic research.

[98]  Meir Kryger,et al.  Reducing motor-vehicle collisions, costs, and fatalities by treating obstructive sleep apnea syndrome. , 2004, Sleep.

[99]  S. Ancoli-Israel,et al.  Sleep disturbances and chronic disease in older adults: results of the 2003 National Sleep Foundation Sleep in America Survey. , 2004, Journal of psychosomatic research.

[100]  P. Harmer,et al.  Tai Chi and Self‐Rated Quality of Sleep and Daytime Sleepiness in Older Adults: A Randomized Controlled Trial , 2004, Journal of the American Geriatrics Society.

[101]  Matthew Robert Justin Baldock,et al.  Self-reported medication use and on-road driving performance of older drivers , 2004 .

[102]  T. Betts,et al.  The effects of two antidepressants, imipramine and viloxazine, upon driving performance , 1977, Psychopharmacology.

[103]  Anup V. Desai,et al.  Sleepiness, sleep-disordered breathing, and accident risk factors in commercial vehicle drivers. , 2004, American journal of respiratory and critical care medicine.

[104]  David Shinar,et al.  Imperfect In-Vehicle Collision Avoidance Warning Systems Can Aid Drivers , 2004, Hum. Factors.

[105]  J. Gurwitz Polypharmacy: a new paradigm for quality drug therapy in the elderly? , 2004, Archives of internal medicine.

[106]  Charlotte Meindorfner,et al.  Driving in Parkinson's disease: Mobility, accidents, and sudden onset of sleep at the wheel , 2005, Movement disorders : official journal of the Movement Disorder Society.

[107]  David F. Mastin,et al.  Personality as a predictor of the objective and subjective impact of sleep deprivation , 2005 .

[108]  C. Guilleminault,et al.  Fatigue, sleep restriction and driving performance. , 2005, Accident; analysis and prevention.

[109]  James R. Sayer,et al.  Automotive Collision Avoidance System Field Operational Test Report: Methodology and Results Appendices , 2005 .

[110]  A. Muzet,et al.  Effect of driving duration and partial sleep deprivation on subsequent alertness and performance of car drivers , 2005, Physiology & Behavior.

[111]  F. Speizer,et al.  Extended work shifts and the risk of motor vehicle crashes among interns. , 2005, The New England journal of medicine.

[112]  E. Bixler,et al.  Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression. , 2005, The Journal of clinical endocrinology and metabolism.

[113]  David J Roberts Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic. , 2005, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[114]  H. Lai,et al.  Music improves sleep quality in older adults. , 2005, Journal of advanced nursing.

[115]  James R. Sayer,et al.  Road Departure Crash Warning System Field Operational Test: Methodology and Results. Volume 1: Technical Report , 2006 .

[116]  J. Walsh,et al.  Laboratory and field studies of naps and caffeine as practical countermeasures for sleep-wake problems associated with night work. , 2006, Sleep.

[117]  E. Dooley National Institute of Neurological Disorders and Stroke , 2006 .

[118]  Countermeasures for sleep loss and deprivation , 2006, Current treatment options in neurology.

[119]  Loren Staplin,et al.  Literature Review of Polypharmacy and Older Drivers: Identifying Strategies to Study Drug Usage and Driving Functioning Among Older Drivers , 2006 .

[120]  B. Phillips Sleepiness, Sleep-Disordered Breathing, and Accident Risk Factors in Commercial Vehicle Drivers , 2006 .

[121]  M. Leechawengwongs,et al.  Role of drowsy driving in traffic accidents: a questionnaire survey of Thai commercial bus/truck drivers. , 2006, Journal of the Medical Association of Thailand = Chotmaihet thangphaet.

[122]  Ulf Landström,et al.  Symptoms of sleepiness while driving and their relationship to prior sleep, work and individual characteristics , 2006 .

[123]  W. Oertel,et al.  Sudden onset of sleep and dopaminergic therapy in patients with restless legs syndrome. , 2006, Sleep medicine.

[124]  David M Gaba,et al.  Improving alertness and performance in emergency department physicians and nurses: the use of planned naps. , 2006, Annals of emergency medicine.

[125]  J. Carrier,et al.  Challenging sleep in aging: the effects of 200 mg of caffeine during the evening in young and middle‐aged moderate caffeine consumers , 2006, Journal of sleep research.

[126]  P. Cooper,et al.  Sleepiness Among Night-Time Drivers: Relationship to Blood Alcohol Concentration and Other Factors , 2006, Traffic injury prevention.

[127]  Wei-Ting Hwang,et al.  The relationship between nurse work schedules, sleep duration, and drowsy driving. , 2007, Sleep.

[128]  Shin Yamamoto,et al.  A driving simulator with driver monitor system , 2007, Systems and Computers in Japan.

[129]  Drew Dawson,et al.  Perception of simulated driving performance after sleep restriction and caffeine. , 2007, Journal of psychosomatic research.

[130]  Yvonne Tran,et al.  The psychophysiological determinants of fatigue. , 2007, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[131]  Arthur F. Kramer,et al.  Influence of Age and Proximity Warning Devices on Collision Avoidance in Simulated Driving , 2007, Hum. Factors.

[132]  B. Reimer,et al.  Task-Induced Fatigue and Collisions in Adult Drivers with Attention Deficit Hyperactivity Disorder , 2007, Traffic injury prevention.

[133]  T. Roth,et al.  Insomnia: definition, prevalence, etiology, and consequences. , 2007, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[134]  M. Jeng,et al.  Driver fatigue and highway driving: A simulator study , 2008, Physiology & Behavior.

[135]  Tal Oron-Gilad,et al.  Alertness maintaining tasks (AMTs) while driving. , 2008, Accident; analysis and prevention.

[136]  E. Bixler,et al.  Lack of regular exercise, depression, and degree of apnea are predictors of excessive daytime sleepiness in patients with sleep apnea: sex differences. , 2008, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[137]  G. F. do Prado,et al.  Physically active elderly women sleep more and better than sedentary women. , 2008, Sleep medicine.

[138]  Georgia Tzamalouka,et al.  An investigation of the effect of sleepiness, drowsy driving, and lifestyle on vehicle crashes , 2008 .

[139]  P. V. Van Ness,et al.  Prevalence of sleep disturbances in a cohort of older drivers. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[140]  J Chliaoutakis,et al.  Exploring the effects of lifestyle, sleep factors and driving behaviors on sleep-related road risk: a study of Greek drivers. , 2008, Accident; analysis and prevention.

[141]  de Dick Waard,et al.  Proceedings 3rd International Driving Symposium on Human Factors in Driver Assessment, Training, and Vehicle Design , 2008 .

[142]  Sherrilene Classen,et al.  Clinical Predictors of Older Driver Performance on a Standardized Road Test , 2008, Traffic injury prevention.

[143]  Clifford Nass,et al.  Assessing the Effectiveness of Interactive Media in Improving Drowsy Driver Safety , 2008, Hum. Factors.

[144]  C. Guilleminault,et al.  Maintenance of Wakefulness Test, obstructive sleep apnea syndrome, and driving risk , 2008, Annals of neurology.

[145]  Ward Vanlaar,et al.  Fatigued and drowsy driving: a survey of attitudes, opinions and behaviors. , 2008, Journal of safety research.

[146]  T. Åkerstedt,et al.  Driver sleepiness and individual differences in preferences for countermeasures , 2008, Journal of sleep research.

[147]  Lisa J. Molnar,et al.  Maintaining Safe Mobility in an Aging Society , 2008 .

[148]  S. Johnsen,et al.  Next‐day cognition, psychomotor function, and driving‐related skills following nighttime administration of eszopiclone , 2008, Human psychopharmacology.

[149]  Catherine Berthelon,et al.  Residual effects of hypnotic drugs in aging drivers submitted to simulated accident scenarios: an exploratory study , 2009, Psychopharmacology.

[150]  T. Leufkens,et al.  Highway Driving in the Elderly the Morning After Bedtime Use of Hypnotics: A Comparison Between Temazepam 20 mg, Zopiclone 7.5 mg, and Placebo , 2009, Journal of clinical psychopharmacology.

[151]  J. Parish Sleep-related problems in common medical conditions. , 2009, Chest.

[152]  C. Morin,et al.  Insomnia and its relationship to health-care utilization, work absenteeism, productivity and accidents. , 2009, Sleep medicine.

[153]  Tal Oron-Gilad,et al.  The effects of an interactive cognitive task (ICT) in suppressing fatigue symptoms in driving , 2009 .

[154]  Carryl L. Baldwin,et al.  Driver fatigue: The importance of identifying causal factors of fatigue when considering detection and countermeasure technologies , 2009 .

[155]  Shang-Fei Hu,et al.  Pulse wave sensor for non-intrusive driver's drowsiness detection , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[156]  P. Philip,et al.  Effects of a combination of napping and bright light pulses on shift workers' sleepiness at the wheel: a pilot study , 2009, Journal of sleep research.

[157]  Yutaka Hirata,et al.  Detection and prediction of drowsiness by reflexive eye movements , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[158]  D. Hudgel,et al.  Comparative levels of excessive daytime sleepiness in common medical disorders. , 2010, Sleep medicine.

[159]  Akiko Noda,et al.  Insufficient sleep impairs driving performance and cognitive function , 2010, Neuroscience Letters.

[160]  T. Åkerstedt,et al.  Reaction of sleepiness indicators to partial sleep deprivation, time of day and time on task in a driving simulator – the DROWSI project , 2009, Journal of sleep research.

[161]  A. Wierzbicka,et al.  Modafinil for narcolepsy: systematic review and meta-analysis. , 2010, Medical science monitor : international medical journal of experimental and clinical research.

[162]  J. Roszkowska,et al.  Management of insomnia in the geriatric patient. , 2010, The American journal of medicine.

[163]  M. Kamijima,et al.  Brief hourly exercise during night work can help maintain workers' performance. , 2010, Industrial health.

[164]  T. Åkerstedt,et al.  SLEEP AND SLEEPINESS: IMPACT OF ENTERING OR LEAVING SHIFTWORK—A PROSPECTIVE STUDY , 2010, Chronobiology international.

[165]  S. Pallesen,et al.  Measures to counteract the negative effects of night work. , 2010, Scandinavian journal of work, environment & health.

[166]  Neal Rogness,et al.  An Interventional Approach for Patient and Nurse Safety: A Fatigue Countermeasures Feasibility Study , 2010, Nursing research.

[167]  C. Drake,et al.  The 10-year risk of verified motor vehicle crashes in relation to physiologic sleepiness. , 2010, Sleep.

[168]  Erik Naylor,et al.  Aerobic exercise improves self-reported sleep and quality of life in older adults with insomnia. , 2010, Sleep medicine.

[169]  M. Silber,et al.  Restless legs syndrome: understanding its consequences and the need for better treatment. , 2010, Sleep medicine.

[170]  Janine Duke,et al.  Age-related safety in professional heavy vehicle drivers: a literature review. , 2010, Accident; analysis and prevention.

[171]  Maurice M Ohayon,et al.  CONSEQUENCES OF SHIFTWORKING ON SLEEP DURATION, SLEEPINESS, AND SLEEP ATTACKS , 2010, Chronobiology international.

[172]  B. Bioulac,et al.  Sleep disorders and accidental risk in a large group of regular registered highway drivers. , 2010, Sleep medicine.

[173]  B. Penninx,et al.  Insomnia and sleep duration in a large cohort of patients with major depressive disorder and anxiety disorders. , 2010, The Journal of clinical psychiatry.

[174]  O. Aminian,et al.  The effect of bright light on sleepiness among rapid-rotating 12-hour shift workers. , 2011, Scandinavian journal of work, environment & health.