24yr old female presented with an anterior neck lump for 3 weeks duration; was found to have solitary nodule on right lobe of the thyroid gland without palpable cervical nodes. She was biochemically euthyroid and Fine Needle Aspiration cytology (FNAC) of the solitary nodule revealed PTC with background autoimmune thyroiditis. She was diagnosed with Familial adenomatous polyposis coli; with a history of subtotal c o l e c t o m y f o r m o d e r a t e l y d i f f e r e n t i a t e d adenocarcinoma of the cecum (T4N1Mx) one year back. She underwent total thyroidectomy with level VI nodal clearance. Histopathology reveled columnar cell variant of PTC without Capsular or vascular invasion or excision margin involvement. She received radioactive Iodine treatment following surgery and was followed up at cancer institute. 9 months following the thyroid surgery she was found to have vertebral metastasis which was histologically confirmed as metastatic PTC deposit. Irrespective of oncological management she died 15 months following thyroid surgery.
[1]
Z. Baloch,et al.
Aggressive variants of follicular cell derived thyroid carcinoma; the so called ‘Real Thyroid Carcinomas’
,
2013,
Journal of Clinical Pathology.
[2]
S. Roman,et al.
Aggressive Variants of Papillary Thyroid Cancer: Incidence, Characteristics and Predictors of Survival among 43,738 Patients
,
2012,
Annals of Surgical Oncology.
[3]
Z. Baloch,et al.
CDX2 expression in columnar cell variant of papillary thyroid carcinoma.
,
2012,
American journal of clinical pathology.
[4]
R. Owen,et al.
Aggressive variants of papillary thyroid carcinoma
,
2011,
Head & neck.
[5]
S. Bigler,et al.
Papillary thyroid carcinoma and familial adenomatous polyposis of the colon.
,
2009,
American journal of otolaryngology.