Liver functional reserve estimation: state of the art and relevance for local treatments

Liver function reserve estimation is important for selecting the appropriate patients for hepatectomy or ablation of tumors. Many liver function tests have been devised, but the indocyanine green (ICG) clearance test remains the most popular for its simplicity and perhaps accuracy. Compared with the Child–Pugh classification, the ICG retention value at 15 min (ICGR-15) after intravenous injection provides more information. Though a significant difference in ICGR-15 has been observed between patients with Child–Pugh A and B liver function, the hospital mortality rates following partial hepatectomy are not significantly different between the two groups. Yet, ICGR-15 values can differentiate patients with or without hospital mortality. The cutoff values of ICGR-15 for a safe major and minor hepatectomy are 14 and 22%, respectively.

[1]  Y. Ilan,et al.  Utility of a 13C‐methacetin breath test in evaluating hepatic injury in rats , 2008, Journal of gastroenterology and hepatology.

[2]  C. Lo,et al.  Evaluation of indocyanine green retention and aminopyrine breath tests in patients with malignant biliary obstruction. , 1994, The Australian and New Zealand journal of surgery.

[3]  M. Vivarelli,et al.  Recovery from liver failure after hepatectomy for hepatocellular carcinoma in cirrhosis: meaning of the model for end-stage liver disease. , 2006, Journal of the American College of Surgeons.

[4]  K. Hanazaki,et al.  Arterial ketone body ratio does not correlate with ischemic changes during major hepatectomy. , 1998, Hepato-gastroenterology.

[5]  V. Armstrong,et al.  The MEGX Test: A Tool for the Real-Time Assessment of Hepatic Function , 2001, Therapeutic drug monitoring.

[6]  S. Ohwada,et al.  Perioperative real‐time monitoring of indocyanine green clearance by pulse spectrophotometry predicts remnant liver functional reserve in resection of hepatocellular carcinoma , 2006, The British journal of surgery.

[7]  D. Gomez,et al.  Quantitative Assessment of Hepatic Function and its Relevance to the Liver Surgeon , 2009, Journal of Gastrointestinal Surgery.

[8]  Jyh‐cherng Yu,et al.  Accuracy of indocyanine green pulse spectrophotometry clearance test for liver function prediction in transplanted patients. , 2004, World journal of gastroenterology.

[9]  C. Ebener,et al.  Evaluation of Liver Function Tests to Predict Operative Risk in Liver Surgery , 1995, HPB surgery : a world journal of hepatic, pancreatic and biliary surgery.

[10]  Y. Matsui,et al.  Preoperative regional maximal removal rate of technetium-99m-galactosyl human serum albumin (GSA-Rmax) is useful for judging the safety of hepatic resection. , 2006, Surgery.

[11]  P. Ghaneh,et al.  Perioperative use of the LiMON method of indocyanine green elimination measurement for the prediction and early detection of post-hepatectomy liver failure. , 2009, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[12]  L. Capussotti,et al.  Indication of the extent of hepatectomy for hepatocellular carcinoma on cirrhosis by a simple algorithm based on preoperative variables. , 2009, Archives of surgery.

[13]  S. Fan,et al.  Improving Perioperative Outcome Expands the Role of Hepatectomy in Management of Benign and Malignant Hepatobiliary Diseases: Analysis of 1222 Consecutive Patients From a Prospective Database , 2004, Annals of surgery.

[14]  P. Kruger,et al.  INDOCYANINE GREEN ELIMINATION: A COMPARISON OF THE LiMON AND SERIAL BLOOD SAMPLING METHODS , 2006, ANZ journal of surgery.

[15]  M. Makuuchi,et al.  Assessment of hepatic reserve for indication of hepatic resection: decision tree incorporating indocyanine green test. , 2005, Journal of hepato-biliary-pancreatic surgery.

[16]  Lawrence H. Schwartz,et al.  Volumetric analysis predicts hepatic dysfunction in patients undergoing major liver resection , 2003, Journal of Gastrointestinal Surgery.

[17]  M. Makuuchi,et al.  Measurement of liver volume and hepatic functional reserve as a guide to decision‐making in resectional surgery for hepatic tumors , 1997, Hepatology.

[18]  C. Lo,et al.  Major hepatectomy for hepatocellular carcinoma in patients with an unsatisfactory indocyanine green clearance test , 1999, The British journal of surgery.

[19]  T M Therneau,et al.  A model to predict survival in patients with end‐stage liver disease , 2001, Hepatology.

[20]  S. Fan,et al.  Tolerance of radiofrequency ablation by patients of hepatocellular carcinoma. , 2009, Journal of hepato-biliary-pancreatic surgery.

[21]  Sheung Tat Fan,et al.  Estimating liver weight of adults by body weight and gender. , 2006, World journal of gastroenterology.

[22]  S. Fan,et al.  Hepatectomy for hepatocellular carcinoma: toward zero hospital deaths. , 1999, Annals of surgery.

[23]  M. Makuuchi,et al.  Patterns of chemotherapy-induced hepatic injury and their implications for patients undergoing liver resection for colorectal liver metastases. , 2009, Journal of hepato-biliary-pancreatic surgery.

[24]  Y. Yamaoka,et al.  Changes in arterial ketone body ratio in the phase immediately after hepatectomy. Prognostic implications. , 1990, Archives of surgery.

[25]  N Tonami,et al.  Preoperative assessment of residual hepatic functional reserve using 99mTc-DTPA-galactosyl-human serum albumin dynamic SPECT. , 1999, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[26]  P. Neuhaus,et al.  Prediction of Postoperative Outcome After Hepatectomy With a New Bedside Test for Maximal Liver Function Capacity , 2009, Annals of surgery.

[27]  S. Shaldon,et al.  The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. , 1961, Clinical science.

[28]  M. Makuuchi,et al.  No-mortality liver resection for hepatocellular carcinoma in cirrhotic and noncirrhotic patients: is there a way? A prospective analysis of our approach. , 1999, Archives of surgery.

[29]  Ashraf A. Omar,et al.  Liver fibrosis: consensus recommendations of the Asian Pacific Association for the Study of the Liver (APASL) , 2009, Hepatology international.

[30]  C. Lo,et al.  Major hepatic resection for primary and metastatic tumors , 2007 .

[31]  O. Farges,et al.  The “50-50 Criteria” on Postoperative Day 5: An Accurate Predictor of Liver Failure and Death After Hepatectomy , 2005, Annals of surgery.

[32]  S. Fan,et al.  Hospital mortality of major hepatectomy for hepatocellular carcinoma associated with cirrhosis. , 1995, Archives of surgery.

[33]  S. Kubo,et al.  A simple, noninvasively determined index predicting hepatic failure following liver resection for hepatocellular carcinoma. , 2009, Journal of hepato-biliary-pancreatic surgery.

[34]  K. Man,et al.  Evaluation of preoperative hepatic function in patients with hepatocellular carcinoma undergoing hepatectomy , 1997, The British journal of surgery.

[35]  S J Wigmore,et al.  The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection , 2005, Gut.