LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.

[1]  J. Bischoff,et al.  Endothelial-Mesenchymal Transition in Cardiovascular Disease. , 2021, Arteriosclerosis, thrombosis, and vascular biology.

[2]  V. Calderone,et al.  Modulation of EndMT by Hydrogen Sulfide in the Prevention of Cardiovascular Fibrosis , 2021, Antioxidants.

[3]  Wei Liu,et al.  Mechanisms and Therapeutic Prospects of Diabetic Cardiomyopathy Through the Inflammatory Response , 2021, Frontiers in Physiology.

[4]  H. Lv,et al.  DNMT1-mediated lncRNA MEG3 methylation accelerates endothelial-mesenchymal transition in diabetic retinopathy through the PI3K/AKT/mTOR signaling pathway. , 2020, American journal of physiology. Endocrinology and metabolism.

[5]  W. Koch,et al.  KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. , 2020, Circulation research.

[6]  Tongbin Li,et al.  Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway , 2020, Diabetes, metabolic syndrome and obesity : targets and therapy.

[7]  Hao Yu,et al.  Knockdown of LncRNA-H19 Ameliorates Kidney Fibrosis in Diabetic Mice by Suppressing miR-29a-Mediated EndMT , 2020, Frontiers in Pharmacology.

[8]  Chao-shu Tang,et al.  Persulfidation of transcription factor FOXO1 at cysteine 457: A novel mechanism by which H2S inhibits vascular smooth muscle cell proliferation , 2020, Journal of advanced research.

[9]  Yunfeng Zhou,et al.  UBE2T promotes radiation resistance in non-small cell lung cancer via inducing epithelial-mesenchymal transition and the ubiquitination-mediated FOXO1 degradation. , 2020, Cancer letters.

[10]  Yinghong Zhang,et al.  MicroRNA-33a-5p sponges to inhibit pancreatic β-cell function in gestational diabetes mellitus LncRNA DANCR , 2020, Reproductive Biology and Endocrinology.

[11]  R. Ritchie,et al.  Basic Mechanisms of Diabetic Heart Disease. , 2020, Circulation research.

[12]  S. Morris,et al.  Enhancing Kidney DDAH-1 Expression by Adenovirus Delivery Reduces ADMA and Ameliorates Diabetic Nephropathy. , 2020, American journal of physiology. Renal physiology.

[13]  Yanyan Guo,et al.  LncRNA ANCR Promotes Invasion and Migration of Gastric Cancer by Regulating FoxO1 Expression to Inhibit Macrophage M1 Polarization , 2020, Digestive Diseases and Sciences.

[14]  C. Cheung,et al.  Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats , 2019, Journal of cellular and molecular medicine.

[15]  E. K. Weir,et al.  Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. , 2019, International journal of cardiology.

[16]  Jun-Lin Jiang,et al.  Asymmetric dimethylarginine aggravates blood–retinal barrier breakdown of diabetic retinopathy via inhibition of intercellular communication in retinal pericytes , 2019, Amino Acids.

[17]  Liefeng Wang,et al.  The role of long noncoding RNA in major human disease. , 2019, Bioorganic chemistry.

[18]  A. Palazzuoli,et al.  Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy , 2019, International journal of molecular sciences.

[19]  B. Greenberg,et al.  Mechanisms of cardiac collagen deposition in experimental models and human disease. , 2019, Translational research : the journal of laboratory and clinical medicine.

[20]  S. Chakrabarti,et al.  lncRNA H19 prevents endothelial–mesenchymal transition in diabetic retinopathy , 2019, Diabetologia.

[21]  Lei Jiang,et al.  miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[22]  Peng Liu,et al.  Long noncoding RNA DANCR mediates cisplatin resistance in glioma cells via activating AXL/PI3K/Akt/NF-κB signaling pathway , 2018, Neurochemistry International.

[23]  A. Zampetaki,et al.  Long Non-coding RNA Structure and Function: Is There a Link? , 2018, Front. Physiol..

[24]  X. Tu,et al.  Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy , 2018, Acta Pharmacologica Sinica.

[25]  Zhenyu Tang,et al.  LncRNA DANCR involved osteolysis after total hip arthroplasty by regulating FOXO1 expression to inhibit osteoblast differentiation , 2018, Journal of Biomedical Science.

[26]  P. Tontonoz,et al.  Long Noncoding RNA Discovery in Cardiovascular Disease: Decoding Form to Function , 2018, Circulation research.

[27]  Jianwei Cao,et al.  Dimethylarginine Dimethylaminohydrolase 1 Deficiency Induces the Epithelial to Mesenchymal Transition in Renal Proximal Tubular Epithelial Cells and Exacerbates Kidney Damage in Aged and Diabetic Mice. , 2017, Antioxidants & redox signaling.

[28]  Xinli Hu,et al.  Cardiomyocyte dimethylarginine dimethylaminohydrolase-1 (DDAH1) plays an important role in attenuating ventricular hypertrophy and dysfunction , 2017, Basic Research in Cardiology.

[29]  Zhisheng Jiang,et al.  Endothelial-to-mesenchymal transition: A novel therapeutic target for cardiovascular diseases. , 2017, Trends in cardiovascular medicine.

[30]  L. Cai,et al.  Pathophysiological Fundamentals of Diabetic Cardiomyopathy. , 2017, Comprehensive Physiology.

[31]  Jianning Zhao,et al.  Long Noncoding RNA DANCR Is a Positive Regulator of Proliferation and Chondrogenic Differentiation in Human Synovium-Derived Stem Cells. , 2017, DNA and cell biology.

[32]  P. Liu,et al.  FOXO1 inhibits the invasion and metastasis of hepatocellular carcinoma by reversing ZEB2-induced epithelial-mesenchymal transition , 2016, Oncotarget.

[33]  A. Mangoni,et al.  Inhibitors of the Hydrolytic Enzyme Dimethylarginine Dimethylaminohydrolase (DDAH): Discovery, Synthesis and Development , 2016, Molecules.

[34]  F. Mendoza,et al.  Endothelial to Mesenchymal Transition (EndoMT) in the Pathogenesis of Human Fibrotic Diseases , 2016, Journal of clinical medicine.

[35]  S. Chakrabarti,et al.  miR-200b Mediates Endothelial-to-Mesenchymal Transition in Diabetic Cardiomyopathy , 2015, Diabetes.

[36]  Haobo Li,et al.  N-Acetylcysteine Restores Sevoflurane Postconditioning Cardioprotection against Myocardial Ischemia-Reperfusion Injury in Diabetic Rats , 2015, Journal of diabetes research.

[37]  R. Stoehr,et al.  FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis. , 2015, Atherosclerosis.

[38]  S. Chakrabarti,et al.  Mechanisms of endothelial to mesenchymal transition in the retina in diabetes. , 2014, Investigative ophthalmology & visual science.

[39]  R. Kalluri,et al.  Increased concentration of circulating angiogenesis and nitric oxide inhibitors induces endothelial to mesenchymal transition and myocardial fibrosis in patients with chronic kidney disease. , 2014, International journal of cardiology.

[40]  Yu-Chieh Chen,et al.  Increased Circulatory Asymmetric Dimethylarginine and Multiple Organ Failure: Bile Duct Ligation in Rat as a Model , 2014, International journal of molecular sciences.

[41]  J. Cooke,et al.  A Novel and Potent Inhibitor of Dimethylarginine Dimethylaminohydrolase: A Modulator of Cardiovascular Nitric Oxide , 2014, The Journal of Pharmacology and Experimental Therapeutics.

[42]  Cheng Huang,et al.  Epigenetic regulation of cardiac fibrosis. , 2013, Cellular signalling.

[43]  Z. Xuan,et al.  Long Non-Coding RNAs and Complex Human Diseases , 2013, International journal of molecular sciences.

[44]  S. Raptis,et al.  Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals , 2012, Cardiovascular Diabetology.

[45]  Zhiyong Cheng,et al.  Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. , 2011, Antioxidants & redox signaling.

[46]  J. Boffa,et al.  Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF‐β1 synthesis , 2011, The Journal of pathology.

[47]  K. Hirata,et al.  Endothelial Cell–Derived Endothelin-1 Promotes Cardiac Fibrosis in Diabetic Hearts Through Stimulation of Endothelial-to-Mesenchymal Transition , 2010, Circulation.

[48]  J. Bertram,et al.  Endothelial-myofibroblast transition contributes to the early development of diabetic renal interstitial fibrosis in streptozotocin-induced diabetic mice. , 2009, The American journal of pathology.

[49]  A. Holian,et al.  Elevated asymmetric dimethylarginine alters lung function and induces collagen deposition in mice. , 2009, American journal of respiratory cell and molecular biology.

[50]  M. Wolzt,et al.  ADMA, cardiovascular disease and diabetes. , 2008, Diabetes research and clinical practice.

[51]  Raghu Kalluri,et al.  Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. , 2008, Journal of the American Society of Nephrology : JASN.

[52]  A. Brunet,et al.  The FoxO code , 2008, Oncogene.

[53]  T. Wynn,et al.  Cellular and molecular mechanisms of fibrosis , 2008, The Journal of pathology.

[54]  Maristela L Onozato,et al.  Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. , 2007, American journal of physiology. Heart and circulatory physiology.

[55]  S. Anker,et al.  Contributions of Inflammation and Cardiac Matrix Metalloproteinase Activity to Cardiac Failure in Diabetic Cardiomyopathy , 2007, Diabetes.

[56]  Michael Majeski,et al.  Multiple elements regulate nuclear/cytoplasmic shuttling of FOXO1: characterization of phosphorylation- and 14-3-3-dependent and -independent mechanisms. , 2004, The Biochemical journal.

[57]  P. Tsao,et al.  Impaired Nitric Oxide Synthase Pathway in Diabetes Mellitus: Role of Asymmetric Dimethylarginine and Dimethylarginine Dimethylaminohydrolase , 2002, Circulation.

[58]  M. Shimizu,et al.  Collagen remodelling in myocardia of patients with diabetes. , 1993, Journal of clinical pathology.

[59]  J. Sowers,et al.  Diabetic cardiomyopathy: a hyperglycaemia- and insulin-resistance-induced heart disease , 2017, Diabetologia.