Protein Micro-Characterization by Mass Spectrometry: Sample Handling and Data Flow

Mass spectrometry (MS) occupies center position in most current protein identification schemes. “Mass fingerprinting” techniques rely on composite mass patterns of proteolytic fragments, or dissociation products thereof, to query databases [1–6]. Two issues, however, need to be addressed at the present time. Are we ready for high throughput analyses in a reliable, efficient and timely manner, and to apply these tools towards rationally selected, meaningful research problems?

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