Transcranial direct current stimulation increases resting state interhemispheric connectivity

Transcranial direct current stimulation (tDCS) has been increasingly used to investigate human brain functions. Especially, tDCS on the dorsolateral prefrontal cortex (DLPFC) enhances cognitive functions in both healthy subjects and patients with neuropsychiatric disorders. In spite of its effects on behavioral improvement, neural correlates of tDCS on the DLPFC have not been fully described. In this study, we acquired resting state functional magnetic resonance imaging data before and after real or sham stimulation on the left DLPFC. Resting state functional connectivity of the stimulated brain region was compared between the two groups. Compared to the sham stimulation group, the tDCS group showed increased DLPFC connectivity to the right hemisphere and decreased DLPFC connectivity to the brain regions around the stimulation site in the left hemisphere. Application of tDCS on the DLPFC may induce increased interhemispheric connectivity even at rest, possibly associated with the behavioral effects of tDCS.

[1]  Francesco Rundo,et al.  Fronto-parietal coupling of brain rhythms in mild cognitive impairment: A multicentric EEG study , 2006, Brain Research Bulletin.

[2]  J. Bradshaw,et al.  Functional connectivity of the prefrontal cortex in Huntington’s disease , 2006, Journal of Neurology, Neurosurgery & Psychiatry.

[3]  Alvaro Pascual-Leone,et al.  Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease , 2006, Journal of the Neurological Sciences.

[4]  N. Birbaumer,et al.  Enhancement of Planning Ability by Transcranial Direct Current Stimulation , 2009, The Journal of Neuroscience.

[5]  Dhruman Goradia,et al.  Corpus Callosum Volume and Neurocognition in Autism , 2009, Journal of autism and developmental disorders.

[6]  Uwe Herwig,et al.  Using the International 10-20 EEG System for Positioning of Transcranial Magnetic Stimulation , 2004, Brain Topography.

[7]  Sergio P. Rigonatti,et al.  Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory , 2005, Experimental Brain Research.

[8]  Richard S. J. Frackowiak,et al.  How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain? , 2005, The European journal of neuroscience.

[9]  H. Möller,et al.  Prefrontal Transcranial Direct Current Stimulation Changes Connectivity of Resting-State Networks during fMRI , 2011, The Journal of Neuroscience.

[10]  Sergio P. Rigonatti,et al.  Go-no-go task performance improvement after anodal transcranial DC stimulation of the left dorsolateral prefrontal cortex in major depression. , 2007, Journal of affective disorders.

[11]  Myoung-Hwan Ko,et al.  Enhancing the Working Memory of Stroke Patients Using tDCS , 2009, American journal of physical medicine & rehabilitation.

[12]  Y. Kim,et al.  Time-dependent effect of transcranial direct current stimulation on the enhancement of working memory , 2008, Neuroreport.

[13]  M. Banich.  The Missing Link: The Role of Interhemispheric Interaction in Attentional Processing , 1998, Brain and Cognition.

[14]  N. Tzourio-Mazoyer,et al.  Automated Anatomical Labeling of Activations in SPM Using a Macroscopic Anatomical Parcellation of the MNI MRI Single-Subject Brain , 2002, NeuroImage.

[15]  Á. Pascual-Leone,et al.  Modulation of large-scale brain networks by transcranial direct current stimulation evidenced by resting-state functional MRI , 2012, Brain Stimulation.

[16]  M. Nitsche,et al.  Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation , 2011, Human brain mapping.

[17]  M. Gazzaniga,et al.  Neuroimaging techniques offer new perspectives on callosal transfer and interhemispheric communication , 2008, Cortex.

[18]  Mi Young Lee,et al.  The effect of transcranial direct current stimulation on the cortical activation by motor task in the human brain: An fMRI study , 2009, Neuroscience Letters.

[19]  Shibu Pillai,et al.  Reduction of functional brain connectivity in mild traumatic brain injury during working memory. , 2009 .