Alterations of muscarinic acetylcholine receptors‐2, 4 and α7‐nicotinic acetylcholine receptor expression after ischaemia / reperfusion in the rat isolated heart

1. Cardiac acetylcholine receptors are involved in the negative inotropic effect of the vagus and the protection of the stimulated vagal nerve against myocardial ischaemic injury. Acetylcholine receptors consist of five types of muscarinic acetylcholine receptors (M AChR) and several nicotinic acetylcholine receptors (nAChR). Notably, ischaemic heart disease is accompanied by substantial withdrawal of vagal activity. However, it is not entirely clear what the changes of M2,4 AChR and α7‐nAChR expression are after cardiac ischaemia/reperfusion (I/R) injury.

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