Depressive symptom‐associated IL‐1β and TNF‐α release correlates with impaired bronchodilator response and neutrophilic airway inflammation in asthma

Depressive symptoms worsen asthma outcomes; however, the mechanism remains largely unexplored.

[1]  M. Hew,et al.  Comorbid “treatable traits” in difficult asthma: Current evidence and clinical evaluation , 2018, Allergy.

[2]  G. Wang,et al.  Identification and validation of asthma phenotypes in Chinese population using cluster analysis. , 2017, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[3]  P. K. Feltes,et al.  Anti-inflammatory treatment for major depressive disorder: implications for patients with an elevated immune profile and non-responders to standard antidepressant therapy , 2017, Journal of psychopharmacology.

[4]  G. Wang,et al.  Severe and uncontrolled asthma in China: a cross-sectional survey from the Australasian Severe Asthma Network. , 2017, Journal of thoracic disease.

[5]  S. Walker,et al.  The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP) , 2017, European Respiratory Journal.

[6]  C. Brightling,et al.  Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma , 2017, Allergy.

[7]  G. Wang,et al.  Interactive effects between obesity and atopy on inflammation: A pilot study for asthma phenotypic overlap. , 2016, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[8]  E. Bleecker,et al.  Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. , 2016, The Lancet. Respiratory medicine.

[9]  G. Wang,et al.  Co-morbid psychological dysfunction is associated with a higher risk of asthma exacerbations: a systematic review and meta-analysis. , 2016, Journal of thoracic disease.

[10]  Zongan Liang,et al.  Th1/Th2/Th17 cells imbalance in patients with asthma with and without psychological symptoms. , 2016, Allergy and asthma proceedings.

[11]  A. James,et al.  Reduced Antiviral Interferon Production in Poorly Controlled Asthma Is Associated With Neutrophilic Inflammation and High-Dose Inhaled Corticosteroids. , 2016, Chest.

[12]  I. Gelissen,et al.  IL‐17A increases TNF‐α‐induced COX‐2 protein stability and augments PGE2 secretion from airway smooth muscle cells: impact on β2‐adrenergic receptor desensitization , 2016, Allergy.

[13]  F. Wright,et al.  Gene expression in major depressive disorder , 2016, Molecular Psychiatry.

[14]  P. Sterk Chronic diseases like asthma and COPD: do they truly exist? , 2016, European Respiratory Journal.

[15]  I. Pavord,et al.  Treatable traits: toward precision medicine of chronic airway diseases , 2016, European Respiratory Journal.

[16]  Andrew H. Miller,et al.  The role of inflammation in depression: from evolutionary imperative to modern treatment target , 2015, Nature Reviews Immunology.

[17]  G. Wang,et al.  Sputum mast cell subtypes relate to eosinophilia and corticosteroid response in asthma , 2015, European Respiratory Journal.

[18]  H. P. Zhang,et al.  Anxiety but not depression symptoms are associated with greater perceived dyspnea in asthma during bronchoconstriction. , 2015, Allergy and asthma proceedings.

[19]  P. Sly,et al.  Phenotypic, functional, and plasticity features of classical and alternatively activated human macrophages. , 2015, American journal of respiratory cell and molecular biology.

[20]  B. Cooper,et al.  Improved criterion for assessing lung function reversibility. , 2015, Chest.

[21]  Miriam Merad,et al.  Neuroimmune mechanisms of depression , 2015, Nature Neuroscience.

[22]  Ayaka Tanaka,et al.  Progression of Irreversible Airflow Limitation in Asthma: Correlation with Severe Exacerbations. , 2015, The journal of allergy and clinical immunology. In practice.

[23]  H. Hakonarson,et al.  Stress and Bronchodilator Response in Children with Asthma. , 2015, American journal of respiratory and critical care medicine.

[24]  D. Longo,et al.  Precision medicine--personalized, problematic, and promising. , 2015, The New England journal of medicine.

[25]  C. Hunter,et al.  IL-6 as a keystone cytokine in health and disease , 2015, Nature Immunology.

[26]  A. Halayko,et al.  Cyclooxygenase-2 and microRNA-155 expression are elevated in asthmatic airway smooth muscle cells. , 2015, American journal of respiratory cell and molecular biology.

[27]  Peter B. Jones,et al.  Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. , 2014, JAMA psychiatry.

[28]  V. Bergink,et al.  Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder , 2014, Translational Psychiatry.

[29]  S. Johnston,et al.  Rhinovirus infection causes steroid resistance in airway epithelium through nuclear factor κB and c-Jun N-terminal kinase activation. , 2013, The Journal of allergy and clinical immunology.

[30]  S. Phipps,et al.  Elevated expression of the NLRP3 inflammasome in neutrophilic asthma , 2013, European Respiratory Journal.

[31]  E. Walker,et al.  Diagnostic and Statistical Manual of Mental Disorders , 2013 .

[32]  P. Cohen,et al.  IL-17 Stimulates Differentiation of Human Anti-Inflammatory Macrophages and Phagocytosis of Apoptotic Neutrophils in Response to IL-10 and Glucocorticoids , 2013, The Journal of Immunology.

[33]  K. Chung,et al.  Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma. , 2012, The Journal of allergy and clinical immunology.

[34]  R. Honkanen,et al.  Cytokines alter glucocorticoid receptor phosphorylation in airway cells: role of phosphatases. , 2012, American journal of respiratory cell and molecular biology.

[35]  G. Wang,et al.  Relationship between Current Psychological Symptoms and Future Risk of Asthma Outcomes: A 12-Month Prospective Cohort Study , 2011, The Journal of asthma : official journal of the Association for the Care of Asthma.

[36]  M. Jarvelin,et al.  Identification of IL6R and chromosome 11q13.5 as risk loci for asthma , 2011, The Lancet.

[37]  Michael Maes Depression is an inflammatory disease, but cell-mediated immune activation is the key component of depression , 2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[38]  Rakesh K. Kumar,et al.  IL-27/IFN-γ Induce MyD88-Dependent Steroid-Resistant Airway Hyperresponsiveness by Inhibiting Glucocorticoid Signaling in Macrophages , 2010, The Journal of Immunology.

[39]  N. Herrmann,et al.  A Meta-Analysis of Cytokines in Major Depression , 2010, Biological Psychiatry.

[40]  P. Gibson,et al.  Inflammatory phenotypes in adult asthma: clinical applications , 2009, The clinical respiratory journal.

[41]  R. Scott,et al.  Clarithromycin targets neutrophilic airway inflammation in refractory asthma. , 2008, American journal of respiratory and critical care medicine.

[42]  I. Pavord,et al.  Association between neutrophilic airway inflammation and airflow limitation in adults with asthma. , 2007, Chest.

[43]  I. Adcock,et al.  Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma. , 2006, American journal of respiratory and critical care medicine.

[44]  J. Hankinson,et al.  Standardisation of spirometry , 2005, European Respiratory Journal.

[45]  J. Gordon,et al.  Opposing effects of short- and long-term stress on airway inflammation. , 2004, American journal of respiratory and critical care medicine.

[46]  Lin Ying Liu,et al.  School examinations enhance airway inflammation to antigen challenge. , 2002, American journal of respiratory and critical care medicine.

[47]  T. T. Haug,et al.  The validity of the Hospital Anxiety and Depression Scale. An updated literature review. , 2002, Journal of psychosomatic research.

[48]  J. Wilson,et al.  The measurement of reticular basement membrane and submucosal collagen in the asthmatic airway , 1997, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[49]  William D. Dupont,et al.  Power and sample size calculations. A review and computer program. , 1990, Controlled clinical trials.

[50]  J. Sweeney,et al.  Blunted beta-adrenergic responsivity of peripheral blood mononuclear cells in endogenous depression. Isoproterenol dose-response studies. , 1988, Archives of general psychiatry.

[51]  M. Sobel Direct and Indirect Effects in Linear Structural Equation Models , 1987 .

[52]  A. Zigmond,et al.  The Hospital Anxiety and Depression Scale , 1983, Acta psychiatrica Scandinavica.

[53]  F. Moreno,et al.  Asthma and Depression: It's Complicated. , 2016, The journal of allergy and clinical immunology. In practice.

[54]  J. Celedón,et al.  Depression, Asthma, and Bronchodilator Response in a Nationwide Study of US Adults. , 2016, The journal of allergy and clinical immunology. In practice.

[55]  K. Chung,et al.  Impaired nuclear translocation of the glucocorticoid receptor in corticosteroid-insensitive airway smooth muscle in severe asthma. , 2015, American journal of respiratory and critical care medicine.

[56]  A. Wanderer Proposed pathobiologic mechanisms of hypoxia-ischemia-reperfusion in corticosteroid-resistant neutrophilic asthma and consideration of interleukin 1 targeted therapy. , 2011, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[57]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.

[58]  G. Borg Psychophysical bases of perceived exertion. , 1982, Medicine and science in sports and exercise.