Comprehensive molecular profiling of lung adenocarcinoma

Steven J. M. Jones | Christopher A. Miller | Joshua M. Stuart | Angela N. Brooks | Richard A. Moore | Christopher R. Cabanski | Benjamin E. Gross | Joshua D. Campbell | Ludmila V. Danilova | Patrick K. Kimes | David I Heiman | D. Haussler | K. Cibulskis | J. Mesirov | E. Lander | R. Wilson | L. Fulton | R. Fulton | E. Mardis | P. Spellman | E. Snyder | L. Chin | G. Getz | M. Meyerson | C. Perou | J. Weinstein | G. Mills | M. Jensen | C. Sougnez | R. Onofrio | L. Ding | M. McLellan | M. Wendl | M. Lawrence | R. Beroukhim | S. Carter | L. Garraway | A. Protopopov | P. Laird | L. Cope | J. Herman | D. Weisenberger | S. Baylin | B. Taylor | N. Schultz | B. Reva | V. Seshan | M. Ladanyi | K. Hoadley | S. Balu | Junyuan Wu | R. Penny | T. Shelton | S. Morris | A. Kahn | B. Ozenberger | M. Brock | E. Gabrielson | J. Schein | M. Wilkerson | C. Stewart | V. Rusch | I. Jurisica | M. Marra | J. Prins | Gordon Robertson | R. Varhol | N. Thiessen | H. Dienemann | D. Beer | G. Sica | H. Thorvaldsdóttir | Y. Butterfield | R. Holt | Angela Tam | Darshan Singh | P. Mieczkowski | C. Kandoth | J. Parker | N. Weinhold | William Lee | E. Collisson | M. Watson | W. Travis | G. Ciriello | P. Hammerman | L. Zou | E. Helman | Jaegil Kim | G. Saksena | Douglas Voet | M. Noble | Pei Lin | Lee T Lichtenstein | David I. Heiman | M. Imieliński | Bryan Hernandez | Eran Hodis | T. Zack | R. Govindan | Jianjiong Gao | Gideon Dresdner | Rileen Sinha | C. Amos | Juok Cho | A. Mungall | C. Fronick | M. Balasundaram | Andy Chu | Noreen Dhalla | R. Guin | Carrie Hirst | Darlene Lee | Michael Mayo | N. Wye | R. Akbani | B. Broom | T. Davidsen | John A. Demchok | Margi Sheth | H. Sofia | Liming Yang | S. Schumacher | A. Berger | W. Richards | C. Creighton | A. Cherniack | Payal Sipahimalani | R. Carlsen | Donghui Tan | Corbin D. Jones | S. Jefferys | S. Waring | Elizabeth Buda | T. Bodenheimer | A. Hoyle | J. Simons | R. Kucherlapati | M. Bootwalla | D. Maglinte | Hailei Zhang | N. Gehlenborg | William Mallard | C. Benz | C. Yau | Yiling Lu | R. Shen | J. Gardner | D. Mallery | J. Paulauskis | Erin E. Curley | L. Thorne | L. Boice | J. Boyd | J. Weaver | M. Iacocca | Jennifer Brown | Christine Czerwinski | L. Huelsenbeck-Dill | B. Rabeno | J. Myers | J. Eckman | Carmelo Gaudioso | R. Dhir | K. Fedosenko | J. Baboud | Deepak Srinivasan | Zhining Wang | R. Tarnuzzer | A. Pantazi | Jiabin Tang | Jingchun Zhu | J. Siegfried | B. Meyers | P. Illei | S. Dacic | E. Duhig | D. Flieder | M. Tsao | M. Zakowski | N. Rekhtman | P. Schnabel | S. Meng | J. Marron | D. Wigle | L. Danilova | S. Ramalingam | Wenbin Liu | D. J. Van Den Berg | J. Roach | Matthew G. Soloway | Umadevi Veluvolu | Kevin R Lau | B. Kohl | O. Potapova | Olga Voronina | M. Behera | Semin Lee | A. Hadjipanayis | Lixing Yang | X. Ren | Peng-Chieh Chen | Marc-Danie Nazaire | S. Ng | Jianhua Zhang | Singer Ma | R. Cheney | W. Funkhouser | F. Kosari | D. Kwiatkowski | M. Peifer | Beverly Lee | D. Trusty | Elena Nemirovich-Danchenko | S. Kodeeswaran | H. Sekhon | R. Hajek | K. Z. Khan | T. Muley | Harshad S. Mahadeshwar | S. Seth | Xingzhi Song | G. Sandusky | Amie Radenbaugh | Monique Albert | E. Burks | Sophie C. Egea | C. Gomez-Fernandez | Lynn M. Herbert | J. Parfitt | K. Rieger-Christ | Charles Saller | T. Sullivan | Katherine Tarvin | M. Meister | S. Yousem | K. Fong | I. Yang | K. R. Mills Shaw | Michael G Parfenov | L. Diao | A. Holway | C. Goparaju | C. Farver | N. Pennell | J. Borgia | M. Liptay | M. Pool | F. Moiseenko | R. Bowman | Jim Robinson | J. Chmielecki | Yan Shi | Kristen Rodgers | D. Raymond | D. Rotin | Carl Morrison | Sandra A. McDonald | P. Bonomi | A. Gal | B. Clarke | C. Williamson | A. Bryant | Peter J. Park | M. Asiedu | Kenna R. Mills Shaw | W. Kimryn Rathmell | I. Letovanec | Thomas Bauer | S. Peters | R. Cerfolio | M. Windsor | C. Sander | D. Neil Hayes | Philip Lai | R. Moore | E. Chuah | Jing Wang | Netty G Santoso | J. Campbell | B. Arman Aksoy | L. Hunter | F. Schneider | Mara W Rosenberg | D. Pot | J. Heymach | Liming Yang | Lixing Yang | H. Li | A. Gordon Robertson | S. Gabriel | Timothy Triche Jr | C. J. D. Creighton Wheeler | S. Onur Sumer | Mei Huang | N. Petrelli | James Shin | D. Dicara | Eric A. Joshua D. Angela N. Alice H. William Juliann Da Collisson Campbell Brooks Berger Lee Chmiele | Lauren Averett Byers | Mara Stacey B. Kristian Carrie Jaegil Chip Lee Eric S. Rosenberg Gabriel Cibulskis Sougnez Kim Stew | Cyriac Robert Lucinda L. Michael D. Richard K. Kai Catrin Kandoth Fulton Fulton McLellan Wilson Ye F | K. Ye | Christopher A. Maher | David Wheeler | Miruna Yaron S. N. Rebecca Andy Eric Noreen Ranabir Carri Balasundaram Butterfield Carlsen Chu Chuah | Joshua D. Angela N. Juliann Marcin Robert C. Eran Travis Campbell Brooks Chmielecki Imielinski Onof | Chandra Sekhar Pedamallu | Angela Semin Harshad S. Angeliki Alexei Xiaojia Sahil Xin Hadjipanayis Lee Mahadeshwar Pantazi Proto | Andrew Wei Xu | Katherine A. J. Shaowu Yan Elizabeth Scot Umadevi Donghui Pi Hoadley Todd Auman Meng Shi Buda Waring | J. Todd Auman | Jinze Liu | Leslie Ludmila Daniel J. Dennis T. Philip H. Moiz S. Davi Cope Danilova Weisenberger Maglinte Lai Bo | Mara Lynda Jianhua Juok Daniel David Pei William Dougla Rosenberg Chin Zhang Cho DiCara Heiman Lin M | William B. Giovanni Barry S. Gideon Jianjiong Benjamin Ven Lee Arman Aksoy Ciriello Taylor Dresdner | Sam Singer Jingchun Amie Joshua M. Christopher C. Chri Ng Ma Zhu Radenbaugh Stuart Benz Yau Haussler | Matthew D. Joel S. Katherine A. Patrick K. D. Charles M. Wilkerson Parker Hoadley Kimes Neil Hayes P | Bradley M. Jing Yiling Patrick Lixia Lauren Wenbin John V. Broom Wang Lu Kwok Shing Ng Diao Averett | Patrick Kwok Shing Ng | Erin Joseph Kevin Scott Troy David Johanna Robert Curley Paulauskis Lau Morris Shelton Mallery Gardn | Charles Katherine Saller Tarvin | Robert Ayesha Cerfolio Bryant | Daniel P. Nathan A. Carol Raymond Pennell Farver | Christine Lori Mary Nicholas Brenda Jennifer Thomas Czerwinski Huelsenbeck-Dill Iacocca Petrelli Rab | Oleg Olga Daniil Olga Elena Konstantin V. Dolzhanskiy Potapova Rotin Voronina Nemirovich-Dan | O. Dolzhanskiy | Anthony Madhusmita Suresh S. Gabriel Gal Behera Ramalingam Sica | Douglas Jeff JoEllen Flieder Boyd Weaver | Bernard Dang Kohl Huy Quoc Thinh | Dang Huy Quoc Thinh | Hartmut Juhl | Peter Edward James Beverly Kristen Dante Malcolm V. Illei Gabrielson Shin Lee Rodgers Trusty Brock | Christina Eric Kimberly Antonia Travis Williamson Burks Rieger-Christ Holway Sullivan | Dennis A. Michael K. Farhad Wigle Asiedu Kosari | William D. Natasha Maureen Valerie W. Travis Rekhtman Zakowski Rusch | Paul James Harvey Chandra Yvonne Zippile Suh Pass Goparaju Owusu-Sarpong | Paul Zippile | James Suh | H. Pass | Y. Owusu-Sarpong | John M. S. Sugy Jeremy Harmanjatinder Monique Bartlett Kodeeswaran Parfitt Sekhon Albert | John M. S. Bartlett | John Jerome B. Eckman Myers | Richard Carl Carmelo Cheney Morrison Gaudioso | Jeffrey A. Philip Mark Michael J. Borgia Bonomi Pool Liptay | Fedor Irina Moiseenko Zaytseva | I. Zaytseva | Hendrik Michael Philipp A. Thomas R. Dienemann Meister Schnabel Muley | Carmen Lynn Sophie Gomez-Fernandez Herbert Egea | Mei Leigh B. Lori Ashley William K. W. Huang Thorne Boice Hill Salazar Funkhouser Kimryn | Ashley Hill Salazar | Rajiv Samuel A. Sanja Frank Jill M. Dhir Yousem Dacic Schneider Siegfried | Mark A. Sandra Bryan Watson McDonald Meyers | Belinda Ian A. Kwun M. Lindy Morgan Rayleen V. Clarke Yang Fong Hunter Windsor Bowman | Solange Igor Peters Letovanec | Mark A. Eric E. Deepak Ari B. Julien David A. Jensen Snyder Srinivasan Kahn Baboud Pot | Kenna R. Margi Tanja John A. Liming Zhining Roy Jean Mills Shaw Sheth Davidsen Demchok Yang Wang Tar | Jean Claude Zenklusen | Bradley A. Heidi J. Ozenberger Sofia | William D. Richard Belinda Sanja Edwina William K. Peter C Travis Cheney Clarke Dacic Duhig Funkhous | Liming Yang | Rileen Sinha | Edwina Duhig | P. Kimes | Travis Zack | Xingzhi Song | Solange Peters | Tanja Davidsen | Nils Weinhold | R. Wilson | Steven J. M. Jones | R. Shen | J. Parker | Angela Hadjipanayis | R. Shen | C. Maher | Rehan Akbani | Nils Gehlenborg | J. S. Marron | Christopher Sander | Moiz Bootwalla

[1]  Chandra Sekhar Pedamallu,et al.  A Pan-Cancer Analysis of Transcriptome Changes Associated with Somatic Mutations in U2AF1 Reveals Commonly Altered Splicing Events , 2014, PloS one.

[2]  J Wala,et al.  Oncogenic RIT1 mutations in lung adenocarcinoma , 2014, Oncogene.

[3]  S. Gabriel,et al.  Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.

[4]  Lu Wang,et al.  Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas. , 2013, Cancer discovery.

[5]  W. Travis,et al.  New pathologic classification of lung cancer: relevance for clinical practice and clinical trials. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  C. Sander,et al.  Pattern discovery and cancer gene identification in integrated cancer genomic data , 2013, Proceedings of the National Academy of Sciences.

[7]  A. Sivachenko,et al.  Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples , 2013, Nature Biotechnology.

[8]  Steven A. Roberts,et al.  Mutational heterogeneity in cancer and the search for new cancer-associated genes , 2013 .

[9]  Yoo Jin Jung,et al.  The transcriptional landscape and mutational profile of lung adenocarcinoma , 2012, Genome research.

[10]  Robert Gentleman,et al.  Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer , 2012, Nature Genetics.

[11]  K. Cibulskis,et al.  Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer , 2012, Nature Genetics.

[12]  Li Ding,et al.  Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers , 2012, Cell.

[13]  Steven J. M. Jones,et al.  Comprehensive genomic characterization of squamous cell lung cancers , 2012, Nature.

[14]  Angela N. Brooks,et al.  Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing , 2012, Cell.

[15]  Hidemi Ito,et al.  Integrated analysis of genetic and epigenetic alterations reveals CpG island methylator phenotype associated with distinct clinical characters of lung adenocarcinoma. , 2012, Carcinogenesis.

[16]  Matthew D. Wilkerson,et al.  Differential Pathogenesis of Lung Adenocarcinoma Subtypes Involving Sequence Mutations, Copy Number, Chromosomal Instability, and Methylation , 2012, PloS one.

[17]  A. McKenna,et al.  Absolute quantification of somatic DNA alterations in human cancer , 2012, Nature Biotechnology.

[18]  W. Pao,et al.  Chipping away at the lung cancer genome , 2012, Nature Medicine.

[19]  A. Tsao,et al.  ROS1 Rearrangements Define a Unique Molecular Class of Lung Cancers , 2012 .

[20]  Masahiro Tsuboi,et al.  International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma , 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[21]  N. Carter,et al.  Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development , 2011, Cell.

[22]  Liu Yan-hui,et al.  Interpretation of Pathological Perspective——International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma , 2011 .

[23]  Jeffrey W. Clark,et al.  Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. , 2010, The New England journal of medicine.

[24]  Adrian V. Lee,et al.  Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer , 2010, Breast Cancer Research.

[25]  Å. Helland,et al.  [Lung cancer in smokers and never-smokers]. , 2009, Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.

[26]  Brian H. Dunford-Shore,et al.  Somatic mutations affect key pathways in lung adenocarcinoma , 2008, Nature.

[27]  Jun Yokota,et al.  Frequent BRG1/SMARCA4–inactivating mutations in human lung cancer cell lines , 2008, Human mutation.

[28]  E. Lander,et al.  Assessing the significance of chromosomal aberrations in cancer: Methodology and application to glioma , 2007, Proceedings of the National Academy of Sciences.

[29]  Derek Y. Chiang,et al.  Characterizing the cancer genome in lung adenocarcinoma , 2007, Nature.

[30]  Stefano Monti,et al.  Gene expression profiling reveals reproducible human lung adenocarcinoma subtypes in multiple independent patient cohorts. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  J. Herman,et al.  Dysfunctional KEAP1–NRF2 Interaction in Non-Small-Cell Lung Cancer , 2006, PLoS medicine.

[32]  Somasekar Seshagiri,et al.  Somatic mutations lead to an oncogenic deletion of met in lung cancer. , 2006, Cancer research.

[33]  S. Toyooka,et al.  The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[34]  Andrew D. Yates,et al.  Athletics: Momentous sprint at the 2156 Olympics? , 2004, Nature.

[35]  S. Gabriel,et al.  EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy , 2004, Science.

[36]  David E. Misek,et al.  Gene-expression profiles predict survival of patients with lung adenocarcinoma , 2002, Nature Medicine.

[37]  David Sidransky,et al.  Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. , 2002, Cancer research.

[38]  Y. Yatabe,et al.  TTF-1 Expression in Pulmonary Adenocarcinomas , 2002, The American journal of surgical pathology.

[39]  E. Lander,et al.  Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  E. Lander,et al.  Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[41]  Michael R. Green,et al.  Functional recognition of the 3′ splice site AG by the splicing factor U2AF35 , 1999, Nature.

[42]  N. Jenkins,et al.  Mga, a dual‐specificity transcription factor that interacts with Max and contains a T‐domain DNA‐binding motif , 1999, The EMBO journal.

[43]  H. Willard,et al.  A novel gene, DXS8237E, lies within 20 kb upstream of UBE1 in Xp11.23 and has a different X inactivation status. , 1996, Genomics.

[44]  C. D. Edwards,et al.  Reciprocal Rb inactivation and p16INK4 expression in primary lung cancers and cell lines. , 1995, Cancer research.

[45]  J. Minna,et al.  p53: a frequent target for genetic abnormalities in lung cancer. , 1989, Science.

[46]  Parag A. Pathak,et al.  Massachusetts Institute of Technology , 1964, Nature.