RECENT ADVANCES IN DEVELOPING INJECTABLE IN-SITU GEL MATRIX SYSTEM FOR CONTROLLED DRUG RELEASE-ON REVIEW

INTRODUCTON Over the past series of years greater interest has been concentrated on designing of sustained and controlled drug delivery systems. Developing of polymeric drug delivery system is extensive research. The designing of in-situ gel systems has received substantial focused over the past few year s. The advantages demonstrate by in-situ forming polymeric delivery systems such as simple manufacture, ease of administration and reduced frequency of administration, improved patient compliance and comfort. In-situ gel formulations ABSTRACT The drug which have poor bioavailability it can be administered through parenteral route is regarded t h most suitable for drug delivery. Parenteral delivery pro vides quick onset of action even for the drug with narrow therapeutic index, but patient discomfort will be c ause due to the maintenance of systemic drug level r p ated installation are required. This type of discomfort can be overcome by developing the drug into a syste m, which improves patient compliance. Injectable in-situ gelling system is one of the types of such system. This biodegradable injectable in-situ gelling drug deliv ry system offer attractive opportunities for prote in (eg: Albumin), Anti-cancer (eg: Melphalan, Cyclophospham ide), NSAIDs (eg: Diclofenac, Indomethacin) drug delivery and may be possibly extend patent life of these drugs. In this article investigate the inject able in-situ gelling system for extended release parenteral drug elivery system and their preparation, mechanism a nd evaluation are discussed.