Persistence of Ebola Virus in Ocular Fluid during Convalescence.

Among the survivors of Ebola virus disease (EVD), complications that include uveitis can develop during convalescence, although the incidence and pathogenesis of EVD-associated uveitis are unknown. We describe a patient who recovered from EVD and was subsequently found to have severe unilateral uveitis during convalescence. Viable Zaire ebolavirus (EBOV) was detected in aqueous humor 14 weeks after the onset of EVD and 9 weeks after the clearance of viremia.

[1]  Elizabeth L. Beam,et al.  The Use of TKM-100802 and Convalescent Plasma in 2 Patients With Ebola Virus Disease in the United States. , 2015, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[2]  Jay B. Varkey,et al.  Successful delivery of RRT in Ebola virus disease. , 2015, Journal of the American Society of Nephrology : JASN.

[3]  Rachel S. G. Sealfon,et al.  Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak , 2014, Science.

[4]  Anne M Winkler,et al.  Laboratory test support for Ebola patients within a high-containment facility. , 2014, Laboratory medicine.

[5]  S. Chee,et al.  Clinical features of cytomegalovirus anterior uveitis in immunocompetent patients. , 2008, American journal of ophthalmology.

[6]  M. Araie,et al.  Herpes simplex virus in the trabeculum of an eye with corneal endotheliitis. , 1999, American journal of ophthalmology.

[7]  J Bertolli,et al.  Clinical, virologic, and immunologic follow-up of convalescent Ebola hemorrhagic fever patients and their household contacts, Kikwit, Democratic Republic of the Congo. Commission de Lutte contre les Epidémies à Kikwit. , 1999, The Journal of infectious diseases.

[8]  R. Colebunders,et al.  Late ophthalmologic manifestations in survivors of the 1995 Ebola virus epidemic in Kikwit, Democratic Republic of the Congo. , 1999, The Journal of infectious diseases.

[9]  A. Sanchez,et al.  Persistence and genetic stability of Ebola virus during the outbreak in Kikwit, Democratic Republic of the Congo, 1995. , 1999, The Journal of infectious diseases.

[10]  B. S. Kuming,et al.  Uveal involvement in Marburg virus disease. , 1977, British Journal of Ophthalmology.

[11]  T. Bothwell,et al.  Outbreake of Marburg virus disease in Johannesburg. , 1975, British medical journal.