Tumor production in the glandular stomach and alimentary tract of the rat by N-methyl-N'-nitro-N-nitrosoguanidine.

Oral administration of N -methyl- N′ -nitro- N -nitrosoguanidine to rats at levels of 33 to 167 µg/ml in the drinking water resulted in a high percentage of adenomas and adenocarcinomas of the glandular stomach. Additionally, rats that were examined after 1 year of experiment showed a variety of other tumors in the duodenum, the jejunum, the liver, and the mesentery. N -Methyl- N′ -nitro- N -nitrosoguanidine is a tool for facile production of adenocarcinoma in the glandular stomach of rats.

[1]  T. Sugimura,et al.  Reaction of N-methyl-N'-nitro-N-nitrosoguanidine with protein. , 1968, Biochimica et biophysica acta.

[2]  P. D. Lawley,et al.  Methylation of DNA by N-Methyl-N-nitrosourethane and N-Methyl-N-nitroso-N′-nitroguanidine , 1968, Nature.

[3]  V. Craddock.  The reaction of N-methyl-N'-nitro-N-nitrosoguanidine with deoxyribonucleic acid. , 1968, The Biochemical journal.

[4]  D. R. McCalla.  Reaction of N-methyl-N'-nitro-N-nitroguanidine and N-methyl-N-nitroso-p-toluenesulfonamide with DNA in vitro. , 1968, Biochimica et biophysica acta.

[5]  A. Ohta,et al.  Carcinoma of the glandular stomach of mice by 4-hydroxyaminoquinoline 1-oxide , 1967 .

[6]  T. Sugimura,et al.  Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine , 1966, Nature.

[7]  R. Schoental.  Carcinogenic Activity of N-Methyl-N-nitroso-N′-nitroguanidine , 1966, Nature.

[8]  H. Morris,et al.  (THE COMBINED EFFECT OF 3-METHYLCHOLANTHRENE AND N,N'-2,7-FLUORENYLENEBISACETMIDE ON THE INDUCTION OF CANCER OF THE GLANDULAR STOMACH OF THE RAT.) , 1965, Journal of the National Cancer Institute.

[9]  R. Schoental.  Induction of Tumours of the Stomach in Rats and Mice by N-nitroso-N-alkylurethanes , 1963, Nature.

[10]  S. Takayama,et al.  Induction of cancer of the glandular stomach in a rat: a new form of experiment. , 1962, Gan.

[11]  J. Greenberg,et al.  A new chemical mutagen for bacteria, 1-methyl-3-nitro-1-nitrosoguanidine. , 1960, Biochemical and biophysical research communications.

[12]  J. Greenstein,et al.  Quantitative nutritional studies with water-soluble, chemically defined diets. III. Individual amino acids as sources of non-essential nitrogen. , 1957, Archives of biochemistry and biophysics.

[13]  H. Stewart,et al.  Tumors of the glandular stomach induced in rats by intramural injection of 20-methylcholanthrene. , 1952, Journal of the National Cancer Institute.

[14]  E. Howes,et al.  Early changes in the experimentally produced adenomas and adenocarcinomas of the stomach. , 1948, Cancer research.