Artificial intelligence biosensors: Challenges and prospects.

Artificial intelligence (AI) and wearable sensors are two essential fields to realize the goal of tailoring the best precision medicine treatment for individual patients. Integration of these two fields enables better acquisition of patient data and improved design of wearable sensors for monitoring the wearers' health, fitness and their surroundings. Currently, as the Internet of Things (IoT), big data and big health move from concept to implementation, AI-biosensors with appropriate technical characteristics are facing new opportunities and challenges. In this paper, the most advanced progress made in the key phases for future wearable and implantable technology from biosensing, wearable biosensing to AI-biosensing is summarized. Without a doubt, material innovation, biorecognition element, signal acquisition and transportation, data processing and intelligence decision system are the most important parts, which are the main focus of the discussion. The challenges and opportunities of AI-biosensors moving forward toward future medicine devices are also discussed.

[1]  Timothy K Lu,et al.  An ingestible bacterial-electronic system to monitor gastrointestinal health , 2018, Science.

[2]  Zhiming Lin,et al.  Large‐Scale and Washable Smart Textiles Based on Triboelectric Nanogenerator Arrays for Self‐Powered Sleeping Monitoring , 2018 .

[3]  E. Bozkurt,et al.  Gingival crevicular fluid and salivary HIF-1α, VEGF, and TNF-α levels in periodontal health and disease. , 2018, Journal of periodontology.

[4]  Yiannos Manoli,et al.  Subcutaneous blood pressure monitoring with an implantable optical sensor , 2013, Biomedical microdevices.

[5]  Shutao Wang,et al.  Bioinspired superwettable micropatterns for biosensing. , 2019, Chemical Society reviews.

[6]  Dae-Hyeong Kim,et al.  Wearable and Implantable Soft Bioelectronics Using Two-Dimensional Materials. , 2018, Accounts of chemical research.

[7]  Mei Yang,et al.  A novel device based on a fluorescent cross-responsive sensor array for detecting lung cancer related volatile organic compounds. , 2015, The Review of scientific instruments.

[8]  M. Bobrek,et al.  Implantable sensor for blood flow monitoring after transplant surgery , 2004, Minimally invasive therapy & allied technologies : MITAT : official journal of the Society for Minimally Invasive Therapy.

[9]  Wei Gao,et al.  A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat , 2019, Nature Biotechnology.

[10]  Zhong Lin Wang,et al.  Triboelectric Nanogenerator Enabled Body Sensor Network for Self-Powered Human Heart-Rate Monitoring. , 2017, ACS nano.

[11]  Joseph Wang,et al.  Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics. , 2015, Biosensors & bioelectronics.

[12]  M. Arab Chamjangali,et al.  An asymmetric flow injection determination of hydroquinone and catechol: An analytic hierarchy and artificial neural network approach , 2019, Measurement.

[13]  Jon R. Askim,et al.  The Optoelectronic Nose: Colorimetric and Fluorometric Sensor Arrays. , 2018, Chemical reviews.

[14]  Adam Heller,et al.  Electrochemical glucose sensors and their applications in diabetes management. , 2008, Chemical reviews.

[15]  Jun Chen,et al.  Titanium-Doped P-Type WO3 Thin Films for Liquefied Petroleum Gas Detection , 2020, Nanomaterials.

[16]  Zhiyu Chen,et al.  A Software Defined Radio Evaluation Platform for WBAN Systems , 2018, Sensors.

[17]  Sergey Shleev,et al.  Biofuel cell as a power source for electronic contact lenses. , 2012, Biosensors & bioelectronics.

[18]  Kiichi Niitsu,et al.  AI-Based Edge-Intelligent Hypoglycemia Prediction System Using Alternate Learning and Inference Method for Blood Glucose Level Data with Low-periodicity , 2019, 2019 IEEE International Conference on Artificial Intelligence Circuits and Systems (AICAS).

[19]  D. Akinwande,et al.  Wearable graphene sensors use ambient light to monitor health , 2019, Nature.

[20]  Nannan Zhang,et al.  Progress in triboelectric nanogenerators as self-powered smart sensors , 2017 .

[21]  Joseph Wang,et al.  Wearable Electrochemical Sensors and Biosensors: A Review , 2013 .

[22]  Teerakiat Kerdcharoen,et al.  A Novel Wearable Electronic Nose for Healthcare Based on Flexible Printed Chemical Sensor Array , 2014, Sensors.

[23]  Yujin Lee,et al.  Hierarchical Cluster Analysis of Medical Chemicals Detected by a Bacteriophage-Based Colorimetric Sensor Array , 2020, Nanomaterials.

[24]  Alberto Escarpa,et al.  Pacifier biosensor: Towards non-invasive saliva biomarker monitoring. , 2019, Analytical chemistry.

[25]  Claudia Heilmann,et al.  An implantable optical blood pressure sensor based on pulse transit time , 2012, Biomedical Microdevices.

[26]  S. Humphrey,et al.  A review of saliva: normal composition, flow, and function. , 2001, The Journal of prosthetic dentistry.

[27]  Jo Woon Chong,et al.  Analyte Quantity Detection from Lateral Flow Assay Using a Smartphone , 2019, Sensors.

[28]  Jun Chen,et al.  Triboelectrification‐Enabled Self‐Powered Detection and Removal of Heavy Metal Ions in Wastewater , 2016, Advanced materials.

[29]  Patricia Connolly,et al.  Development of wearable sensors for tailored patient wound care , 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[30]  Li Wang,et al.  A Novel Optimization Technique to Improve Gas Recognition by Electronic Noses Based on the Enhanced Krill Herd Algorithm , 2016, Sensors.

[31]  Xiangdong Yang,et al.  Recent progress in flexible and wearable bio-electronics based on nanomaterials , 2017, Nano Research.

[32]  Audrey M. Bowen,et al.  Transfer Printing Techniques for Materials Assembly and Micro/Nanodevice Fabrication , 2012, Advanced materials.

[33]  Ping Chen,et al.  Near-Field Communication Sensors , 2019, Sensors.

[34]  Paolo Bollella,et al.  Minimally-invasive Microneedle-based Biosensor Array for Simultaneous Lactate and Glucose Monitoring in Artificial Interstitial Fluid , 2019, Electroanalysis.

[35]  Yadong Jiang,et al.  Alveolus-Inspired Active Membrane Sensors for Self-Powered Wearable Chemical Sensing and Breath Analysis. , 2020, ACS nano.

[36]  Long Lin,et al.  Stretchable‐Rubber‐Based Triboelectric Nanogenerator and Its Application as Self‐Powered Body Motion Sensors , 2015 .

[37]  John A. Rogers,et al.  Wearable electronics: Nanomesh on-skin electronics. , 2017, Nature nanotechnology.

[38]  Sotiris B. Kotsiantis,et al.  Machine learning: a review of classification and combining techniques , 2006, Artificial Intelligence Review.

[39]  John R. Clegg,et al.  Analyte-Responsive Hydrogels: Intelligent Materials for Biosensing and Drug Delivery. , 2017, Accounts of chemical research.

[40]  Frederik C. Krebs,et al.  All solution roll-to-roll processed polymer solar cells free from indium-tin-oxide and vacuum coating steps , 2009 .

[41]  Wei Gao,et al.  Wearable and flexible electronics for continuous molecular monitoring. , 2019, Chemical Society reviews.

[42]  Sam Emaminejad,et al.  Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis , 2016, Nature.

[43]  Jayoung Kim,et al.  Wearable biosensors for healthcare monitoring , 2019, Nature Biotechnology.

[44]  Jun Chen,et al.  Smart Textiles for Electricity Generation. , 2020, Chemical reviews.

[45]  Lazaro Alessandro Soares Nunes,et al.  Clinical and diagnostic utility of saliva as a non-invasive diagnostic fluid:
a systematic review , 2015, Biochemia medica.

[46]  L Tian,et al.  Wearable sensors: modalities, challenges, and prospects. , 2018, Lab on a chip.

[47]  Dae-Hyeong Kim,et al.  Flexible and stretchable electronics for biointegrated devices. , 2012, Annual review of biomedical engineering.

[48]  R. Ghaffari,et al.  Recent Advances in Flexible and Stretchable Bio‐Electronic Devices Integrated with Nanomaterials , 2016, Advanced materials.

[49]  Wenzhao Jia,et al.  Tattoo-based noninvasive glucose monitoring: a proof-of-concept study. , 2015, Analytical chemistry.

[50]  Ioannis Chatzigiannakis,et al.  On the Possibility of Predicting Glycaemia ‘On the Fly’ with Constrained IoT Devices in Type 1 Diabetes Mellitus Patients , 2019, Sensors.

[51]  Zhaona Wang,et al.  Eardrum‐Inspired Active Sensors for Self‐Powered Cardiovascular System Characterization and Throat‐Attached Anti‐Interference Voice Recognition , 2015, Advanced materials.

[52]  Lan Yu,et al.  Lab on the eye: A review of tear-based wearable devices for medical use and health management. , 2019, Bioscience trends.

[53]  John A Rogers,et al.  Skin sensors are the future of health care , 2019, Nature.

[54]  Junjie Bai,et al.  A Self‐Powered Angle Measurement Sensor Based on Triboelectric Nanogenerator , 2015 .

[55]  K. Maniura‐Weber,et al.  Simultaneous detection of pH value and glucose concentrations for wound monitoring applications. , 2017, Biosensors & bioelectronics.

[56]  P. Preshaw,et al.  Salivary cytokines as biomarkers of periodontal diseases. , 2016, Periodontology 2000.

[57]  M. Jakubowska,et al.  Microscale Hybrid Flexible Circuit Printed With Aerosol Jet Technique , 2018, IEEE Transactions on Nanotechnology.

[58]  Liang Li,et al.  Comprehensive and Quantitative Profiling of the Human Sweat Submetabolome Using High-Performance Chemical Isotope Labeling LC-MS. , 2016, Analytical chemistry.

[59]  Chad Darling,et al.  Utilizing an Ingestible Biosensor to Assess Real-Time Medication Adherence , 2015, Journal of Medical Toxicology.

[60]  Joseph Wang,et al.  Electrochemical biosensors: towards point-of-care cancer diagnostics. , 2006, Biosensors & bioelectronics.

[61]  Elad Alon,et al.  Wireless Recording in the Peripheral Nervous System with Ultrasonic Neural Dust , 2016, Neuron.

[62]  J. Windmiller,et al.  Electrochemical tattoo biosensors for real-time noninvasive lactate monitoring in human perspiration. , 2013, Analytical chemistry.

[63]  Jacob Michael C.C. Megan Sapp Carlson,et al.  Determining Data Information Literacy Needs: A Study of Students and Research Faculty , 2011 .

[64]  Gregorio López,et al.  A Review on Architectures and Communications Technologies for Wearable Health-Monitoring Systems , 2012, Sensors.

[65]  Jun Chen,et al.  A self-powered triboelectric nanosensor for mercury ion detection. , 2013, Angewandte Chemie.

[66]  Hengyu Guo,et al.  Blow-driven triboelectric nanogenerator as an active alcohol breath analyzer , 2015 .

[67]  Xueji Zhang,et al.  The role of sampling in wearable sweat sensors. , 2020, Talanta.

[68]  S. N. Sawant,et al.  Development of Biosensors From Biopolymer Composites , 2017 .

[69]  Drew A. Hall,et al.  A Multi-Technique Reconfigurable Electrochemical Biosensor: Enabling Personal Health Monitoring in Mobile Devices , 2016, IEEE Transactions on Biomedical Circuits and Systems.

[70]  Yadong Jiang,et al.  A wireless energy transmission enabled wearable active acetone biosensor for non-invasive prediabetes diagnosis , 2020 .

[71]  Ivana Murković Steinberg,et al.  Wireless chemical sensors and biosensors: A review , 2018, Sensors and Actuators B: Chemical.

[72]  L. C. Clark,et al.  ELECTRODE SYSTEMS FOR CONTINUOUS MONITORING IN CARDIOVASCULAR SURGERY , 1962 .

[73]  Fernando Soto,et al.  A microneedle biosensor for minimally-invasive transdermal detection of nerve agents. , 2017, The Analyst.

[74]  Zufang Huang,et al.  Nasopharyngeal cancer detection based on blood plasma surface-enhanced Raman spectroscopy and multivariate analysis. , 2010, Biosensors & bioelectronics.

[75]  Ashraf Darwish,et al.  Wearable and Implantable Wireless Sensor Network Solutions for Healthcare Monitoring , 2011, Sensors.

[76]  Jun Chen,et al.  Epidermis-Inspired Ultrathin 3D Cellular Sensor Array for Self-Powered Biomedical Monitoring. , 2018, ACS applied materials & interfaces.

[77]  Zhong Lin Wang,et al.  Flexible Weaving Constructed Self‐Powered Pressure Sensor Enabling Continuous Diagnosis of Cardiovascular Disease and Measurement of Cuffless Blood Pressure , 2018, Advanced Functional Materials.

[78]  J. Swett,et al.  Graphene nanoelectrodes for biomolecular sensing , 2017 .

[79]  Dhruv R. Seshadri,et al.  Wearable sensors for monitoring the physiological and biochemical profile of the athlete , 2019, npj Digital Medicine.

[80]  Guang Zhu,et al.  Transparent and flexible barcode based on sliding electrification for self-powered identification systems , 2015 .

[81]  Guang Zhu,et al.  Triboelectric nanogenerators as a new energy technology: From fundamentals, devices, to applications , 2015 .

[82]  Jun Chen,et al.  Single-layered ultra-soft washable smart textiles for all-around ballistocardiograph, respiration, and posture monitoring during sleep. , 2020, Biosensors & bioelectronics.

[83]  Yolanda Gil,et al.  A 20-Year Community Roadmap for Artificial Intelligence Research in the US , 2019, ArXiv.

[84]  Christofer Toumazou,et al.  Continuous in vivo blood pressure measurements using a fully implantable wireless SAW sensor , 2013, Biomedical Microdevices.

[85]  T. G. Drummond,et al.  Electrochemical DNA sensors , 2003, Nature Biotechnology.

[86]  Wei Gao,et al.  Flexible and Superwettable Bands as a Platform toward Sweat Sampling and Sensing. , 2019, Analytical chemistry.

[87]  Matthew Boubin,et al.  Microcontroller Implementation of Support Vector Machine for Detecting Blood Glucose Levels Using Breath Volatile Organic Compounds , 2019, Sensors.

[88]  Benjamin A. Katchman,et al.  Accessing analytes in biofluids for peripheral biochemical monitoring , 2019, Nature Biotechnology.

[89]  Serbulent Tozlu,et al.  Wi-Fi enabled sensors for internet of things: A practical approach , 2012, IEEE Communications Magazine.

[90]  Pedro M. Domingos.  A few useful things to know about machine learning , 2012, Commun. ACM.

[91]  G. S. Wilson,et al.  Electrochemical Biosensors: Recommended Definitions and Classification , 1999, Biosensors & bioelectronics.

[92]  YongAn Huang,et al.  Inkjet printing for flexible electronics: Materials, processes and equipments , 2010 .

[93]  Michael Chung,et al.  Wearable flexible sweat sensors for healthcare monitoring: a review , 2019, Journal of the Royal Society Interface.

[94]  Xuezeng Zhao,et al.  Graphene-based fully integrated portable nanosensing system for on-line detection of cytokine biomarkers in saliva. , 2019, Biosensors & bioelectronics.

[95]  Pietro Salvo,et al.  Sensors and Biosensors for C-Reactive Protein, Temperature and pH, and Their Applications for Monitoring Wound Healing: A Review , 2017, Sensors.

[96]  G. Zhu,et al.  Membrane‐Based Self‐Powered Triboelectric Sensors for Pressure Change Detection and Its Uses in Security Surveillance and Healthcare Monitoring , 2014 .

[97]  Zhong Lin Wang,et al.  High-efficiency ramie fiber degumming and self-powered degumming wastewater treatment using triboelectric nanogenerator , 2016 .

[98]  Jun Chen,et al.  Harmonic‐Resonator‐Based Triboelectric Nanogenerator as a Sustainable Power Source and a Self‐Powered Active Vibration Sensor , 2013, Advanced materials.

[99]  Justin T. Baca,et al.  Proteomic Characterization of Dermal Interstitial Fluid Extracted Using a Novel Microneedle-Assisted Technique. , 2018, Journal of proteome research.

[100]  Peter B. Lillehoj,et al.  Embroidered electrochemical sensors on gauze for rapid quantification of wound biomarkers. , 2017, Biosensors & bioelectronics.