Toxicity, ultrastructural effects, and metabolic studies with 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane(o,p'-DDD) and its methyl analog in the guinea pig and rat.

[1]  R. Anderegg.  Selective reduction of mass spectral data by isotope cluster chromatography , 1981 .

[2]  J. Richie,et al.  Carcinoma of the Adrenal Cortex , 1980, Cancer.

[3]  T. Hogan,et al.  o,p′‐DDD (mitotane) therapy of adrenal cortical carcinoma. Observations on drug dosage, toxicity, and steroid replacement , 1978, Cancer.

[4]  B. E. Evans,et al.  Reactions of Sodiurn Borohydride in Acidic Media; IV. Reduction of Diarylmethanols and Triarylmethanols in Trifluoroacetic Acid1-3 , 1977 .

[5]  J. Sinsheimer,et al.  Metabolism of 1-(0-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane (o,p'-DDD) in rats. , 1975, Drug metabolism and disposition: the biological fate of chemicals.

[6]  J. Sinsheimer,et al.  Aromatic hydroxylation and alkyl oxidation in metabolism of mitotane (o,p'-DDD) in humans. , 1974, Journal of pharmaceutical sciences.

[7]  L. Freeman,et al.  Mitotane use in inoperable adrenal cortical carcinoma. , 1973, JAMA.

[8]  R. Adamson,et al.  The effect of isomers of DDD on the ACTH-induced steroid output, histology and ultrastructure of the dog adrenal cortex. , 1973, Toxicology and applied pharmacology.

[9]  J. Straw,et al.  Effect of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane on adrenocorticotropic hormone-induced steroidogenesis in various preparations in vitro of dog adrenal cortex. , 1971, Biochemical pharmacology.

[10]  J. Straw,et al.  Studies on the site of action of o,p'-DDD in the dog adrenal cortex. 1. Inhibition of ACTH-mediated pregnenolone synthesis. , 1971, Steroids.

[11]  T. Balazs.  Effects of DDD and DDT on the production and metabolism of adrenocortical steroids in guinea pigs and dogs. , 1969, American journal of veterinary research.

[12]  R. Gaunt,et al.  Inhibitors of adrenal cortical function. , 1965, Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie.

[13]  W. Horton,et al.  1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane and Related Compounds1 , 1962 .

[14]  C. Cheng,et al.  SYNTHESIS OF COMPOUNDS RELATED TO 2-(O-CHLORO- PHENYL)-2-(P-CHLOROPHENYL)-1,1-DICHLOROETHANE. , 1962, Journal of medicinal and pharmaceutical chemistry.

[15]  P. Hartroft,et al.  Ultrastructure of adrenal cortex of the dog during treatment with DDD. , 1962, Journal of the National Cancer Institute.

[16]  J. Brown,et al.  THE CHEMICAL FRACTIONATION OF AN ADRENOCORTICOLYTIC DRUG123 , 1958 .

[17]  H. J. Florestano,et al.  Disubstituted Dichlorobenzophenones, Isomeric Dichlorobenzhydrols and Related Compounds , 1955 .

[18]  R. Hayes,et al.  The Chemical Composition of Technical DDT1 , 1945 .