Cerebral asymmetry in 14 year olds born very preterm

The normal pattern of cerebral asymmetry may be altered in neurodevelopmental disorders such as autism and schizophrenia. Babies born very preterm have an increased risk of brain damage, and brain abnormalities which persist into adolescence. This study aimed to ascertain whether preterm birth affects the development of fronto-occipital asymmetry. Structural MRI (magnetic resonance imaging) scans from 14 year old individuals born very preterm (n = 61; mean age 14 years 11 months; 29 male) and age-matched full-term controls (n = 49; mean age 14 years 11 months; 31 male) underwent morphometric analysis, using well-validated stereological methods. Measurements of right and left prefrontal, premotor, sensorimotor and occipitoparietal regional volumes were made and asymmetry indices calculated. These factors underwent a reductive factor analysis. There were no significant between-group differences in fronto-occipital asymmetry between the preterm adolescents and their full-term counterparts. It seems unlikely, therefore, that preterm birth per se deviates the development of normal fronto-occipital asymmetry. Neonatal periventricular haemorrhage with ventricular dilatation revealed by ultrasound may be associated with reversal of asymmetry in the sensorimotor area.

[1]  Volumetric assessment of cerebral asymmetry from CT scans , 1990, Psychiatry Research: Neuroimaging.

[2]  Chiara Nosarti,et al.  Corpus callosum size and very preterm birth: relationship to neuropsychological outcome. , 2004, Brain : a journal of neurology.

[3]  R. Kahn,et al.  Handedness, language lateralisation and anatomical asymmetry in schizophrenia: meta-analysis. , 2001, The British journal of psychiatry : the journal of mental science.

[4]  Alan C. Evans,et al.  Brain development during childhood and adolescence: a longitudinal MRI study , 1999, Nature Neuroscience.

[5]  Michael Vannier,et al.  Human cortical asymmetries determined with 3D MR technology , 1991, Journal of Neuroscience Methods.

[6]  Marjorie LeMay,et al.  Asymmetries of the skull and handedness: Phrenology revisited , 1977, Journal of the Neurological Sciences.

[7]  H J Gundersen,et al.  The efficiency of systematic sampling in stereology and its prediction * , 1987, Journal of microscopy.

[8]  J. Thornton,et al.  Rapid stereological quantitation of temporal neocortex in TLE. , 2003, Magnetic resonance imaging.

[9]  J. Wyatt,et al.  PROBABILITÉ OF NEURODEVELOPMENTAL DISORDERS ESTIMATED FROM ULTRASOUND APPEARANCE OF BRAINS OF VERY PRETERM INFANTS , 1987, Developmental medicine and child neurology.

[10]  Paul J. Harrison,et al.  Laser-assisted microdissection: methods for the molecular analysis of psychiatric disorders at a cellular resolution , 2004, Biological Psychiatry.

[11]  M Ashtari,et al.  Absence of regional hemispheric volume asymmetries in first-episode schizophrenia. , 1994, The American journal of psychiatry.

[12]  Faith M. Gunning-Dixon,et al.  Reversed cerebellar asymmetry in men with First-Episode schizophrenia , 2003, Biological Psychiatry.

[13]  E. Reynolds,et al.  PREDICTION OF NEURODEVELOPMENTAL IMPAIRMENT AT FOUR YEARS FROM BRAIN ULTRASOUND APPEARANCE OF VERY PRETERM INFANTS , 1988, Developmental medicine and child neurology.

[14]  J. Wyatt,et al.  Neuropsychological outcome at adolescence of very preterm birth and its relation to brain structure. , 2001, Developmental medicine and child neurology.

[15]  Alan C. Evans,et al.  Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans. , 2001, Cerebral cortex.

[16]  D. Weinberger,et al.  Asymmetrical volumes of the right and left frontal and occipital regions of the human brain , 1982, Annals of neurology.

[17]  Eve C Johnstone,et al.  Abnormal cerebral asymmetry and schizophrenia in a subject with Klinefelter’s syndrome (XXY) , 2003, Biological Psychiatry.

[18]  Chiara Nosarti,et al.  Adolescents who were born very preterm have decreased brain volumes. , 2002, Brain : a journal of neurology.

[19]  Christopher J. Cannistraci,et al.  Regional brain volume abnormalities and long-term cognitive outcome in preterm infants. , 2000, JAMA.

[20]  N. Geschwind,et al.  Human Brain: Left-Right Asymmetries in Temporal Speech Region , 1968, Science.

[21]  Godfrey Pearlson,et al.  Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives — The Maudsley Family Study , 1999, Schizophrenia Research.

[22]  S. Frangou,et al.  Normal cerebral volume asymmetries in early onset schizophrenia , 2004, Biological Psychiatry.

[23]  A. Edwards,et al.  RELATION BETWEEN ULTRASOUND APPEARANCE OF THE BRAIN OF VERY PRETERM INFANTS AND NEURODEVELOPMENTAL IMPARIMENT AT EIGHT YEARS , 1993, Developmental medicine and child neurology.

[24]  Muriel Walshe,et al.  Brain volumes in familial and non-familial schizophrenic probands and their unaffected relatives. , 2002, American journal of medical genetics.

[25]  R. Royall,et al.  Improving sterological estimates for the volume of structures identified in three-dimensional arrays of spatial data , 1997, Journal of Neuroscience Methods.

[26]  Chiara Nosarti,et al.  Brain volumes in adult survivors of very low birth weight: a sibling-controlled study. , 2004, Pediatrics.

[27]  E. Reynolds,et al.  Ultrasound appearance of the brain in very preterm infants and neurodevelopmental outcome at 18 months of age. , 1983, Archives of disease in childhood.

[28]  N. Gelman,et al.  Uncomplicated Intraventricular Hemorrhage Is Followed by Reduced Cortical Volume at Near-Term Age , 2004, Pediatrics.

[29]  D. Miller,et al.  Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm , 1999, The Lancet.

[30]  Daniel B Hier,et al.  Autism and unfavorable left-right asymmetries of the brain , 1979, Journal of autism and developmental disorders.

[31]  M. Allin,et al.  Cognitive and motor function and the size of the cerebellum in adolescents born very pre-term. , 2001, Brain : a journal of neurology.

[32]  F. Mauguière,et al.  Temporopolar changes in temporal lobe epilepsy: A quantitative MRI-based study , 2002, Neurology.