Prevention of the degeneration of human dopaminergic neurons in an astrocyte co‐culture system allowing endogenous drug metabolism
暂无分享,去创建一个
Marcel Leist | Alexander Bürkle | Liudmila Efremova | M. Leist | A. Bürkle | B. Hanf | S. Schildknecht | S. Gutbier | Stefan Schildknecht | Martina Adam | Regina Pape | Simon Gutbier | Benjamin Hanf | R. Pape | L. Efremova | M. Adam | Simon Gutbier
[1] J. Langston,et al. Can cellular models revolutionize drug discovery in Parkinson's disease? , 2009, Biochimica et biophysica acta.
[2] M. Leist,et al. Uncoupling of ATP-depletion and cell death in human dopaminergic neurons. , 2012, Neurotoxicology.
[3] C. Olanow,et al. Modeling Parkinson's disease , 2009, Annals of neurology.
[4] Nicola J. Allen,et al. Neuroscience: Glia — more than just brain glue , 2009, Nature.
[5] L. Costa,et al. Morphological Assessment of Neurite Outgrowth in Hippocampal Neuron‐Astrocyte Co‐Cultures , 2012, Current protocols in toxicology.
[6] M. Memo,et al. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease , 2012, EMBO molecular medicine.
[7] D. Guastella,et al. Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[8] Hui Ge,et al. Neuroprotective Effects of Protocatechuic Aldehyde against Neurotoxin-Induced Cellular and Animal Models of Parkinson’s Disease , 2013, PloS one.
[9] L. Tönges,et al. Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson’s disease , 2012, Brain : a journal of neurology.
[10] M. Rao,et al. Using Human Pluripotent Stem Cell–Derived Dopaminergic Neurons to Evaluate Candidate Parkinson’s Disease Therapeutic Agents in MPP+ and Rotenone Models , 2013, Journal of biomolecular screening.
[11] Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease , 2007, Neurology.
[12] H. Kang,et al. Poly (ADP-ribose) in the pathogenesis of Parkinson's disease , 2014, BMB reports.
[13] P. Nicotera,et al. ATP Controls Neuronal Apoptosis Triggered by Microtubule Breakdown or Potassium Deprivation , 1999, Molecular medicine.
[14] L. Vécsei,et al. Pharmacological Therapy in Parkinson's Disease: Focus on Neuroprotection , 2011, CNS neuroscience & therapeutics.
[15] M. A. Ajmone-Cat,et al. Astrocytes contribute to neuronal impairment in βA toxicity increasing apoptosis in rat hippocampal neurons , 2001, Glia.
[16] E. Cacci,et al. In vitro neuronal and glial differentiation from embryonic or adult neural precursor cells are differently affected by chronic or acute activation of microglia , 2008, Glia.
[17] D. Standaert,et al. Targets for neuroprotection in Parkinson's disease. , 2009, Biochimica et biophysica acta.
[18] D. Krainc,et al. Human iPSC-based modeling of late-onset disease via progerin-induced aging. , 2013, Cell stem cell.
[19] Huidong Yu,et al. Discovery of a benzofuran derivative (MBPTA) as a novel ROCK inhibitor that protects against MPP⁺-induced oxidative stress and cell death in SH-SY5Y cells. , 2014, Free radical biology & medicine.
[20] P. Mcgeer,et al. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis , 2015, Neurobiology of Aging.
[21] Robert E. Burke,et al. Axon degeneration in Parkinson's disease , 2013, Experimental Neurology.
[22] W. Dauer,et al. Parkinson's Disease Mechanisms and Models , 2003, Neuron.
[23] Adam J Pawson,et al. The Concise Guide to Pharmacology 2013/14: Enzymes , 2013, British journal of pharmacology.
[24] T. Dawson,et al. Parthanatos Mediates AIMP2 Activated Age Dependent Dopaminergic Neuronal Loss , 2013, Nature Neuroscience.
[25] Tanja Waldmann,et al. Rapid, complete and large‐scale generation of post‐mitotic neurons from the human LUHMES cell line , 2011, Journal of neurochemistry.
[26] Jeppe Falsig,et al. Specific Modulation of Astrocyte Inflammation by Inhibition of Mixed Lineage Kinases with CEP-13471 , 2004, The Journal of Immunology.
[27] G. Miller,et al. Industrial toxicants and Parkinson's disease. , 2012, Neurotoxicology.
[28] M. Beal,et al. NOS knockouts and neuroprotection , 1999, Nature Medicine.
[29] D. B. Tower,et al. THE ACTIVITIES OF BUTYRYLCHOLINESTERASE AND CARBONIC ANHYDRASE, THE RATE OF ANAEROBIC GLYCOLYSTS, AND THE QUESTION OF A CONSTANT DENSITY OF GLIAL CELLS IN CEREBRAL CORTICES OF VARIOUS MAMMALIAN SPECIES FROM MOUSE TO WHALE , 1973, Journal of neurochemistry.
[30] J. Cadet,et al. An In Vitro Model of Human Dopaminergic Neurons Derived from Embryonic Stem Cells: MPP+ Toxicity and GDNF Neuroprotection , 2006, Neuropsychopharmacology.
[31] K. McNaught,et al. Altered Glial Function Causes Neuronal Death and Increases Neuronal Susceptibility to 1‐Methyl‐4‐Phenylpyridinium‐ and 6‐Hydroxydopamine‐Induced Toxicity in Astrocytic/Ventral Mesencephalic Co‐Cultures , 1999, Journal of neurochemistry.
[32] A. Henn,et al. Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions. , 2012, ALTEX.
[33] Dorit Merhof,et al. Evaluation of a human neurite growth assay as specific screen for developmental neurotoxicants , 2013, Archives of Toxicology.
[34] P. Brundin,et al. A simple method for large‐scale generation of dopamine neurons from human embryonic stem cells , 2010, Journal of neuroscience research.
[35] J. Pocock,et al. Microglial secreted cathepsin B induces neuronal apoptosis , 2001, Journal of neurochemistry.
[36] Jeppe Falsig,et al. Progressive Degeneration of Human Mesencephalic Neuron-Derived Cells Triggered by Dopamine-Dependent Oxidative Stress Is Dependent on the Mixed-Lineage Kinase Pathway , 2005, The Journal of Neuroscience.
[37] J. Langston,et al. MPTP-induced parkinsonism in human and non-human primates--clinical and experimental aspects. , 1984, Acta neurologica Scandinavica. Supplementum.
[38] M. Smeyne,et al. Strain‐dependent susceptibility to MPTP and MPP+‐induced Parkinsonism is determined by glia , 2001, Glia.
[39] P. Nicotera,et al. 1-Methyl-4-phenylpyridinium induces autocrine excitotoxicity, protease activation, and neuronal apoptosis. , 1998, Molecular pharmacology.
[40] L. Greene,et al. ATF4 Protects Against Neuronal Death in Cellular Parkinson's Disease Models by Maintaining Levels of Parkin , 2013, The Journal of Neuroscience.
[41] M. Youdim. Why Do We Need Multifunctional Neuroprotective and Neurorestorative Drugs for Parkinson's and Alzheimer's Diseases as Disease Modifying Agents , 2010, Experimental neurobiology.
[42] M. Sofroniew,et al. Astrocytes: biology and pathology , 2009, Acta Neuropathologica.
[43] N. Neff,et al. CEP‐1347 (KT7515), an Inhibitor of JNK Activation, Rescues Sympathetic Neurons and Neuronally Differentiated PC12 Cells from Death Evoked by three Distinct Insults , 1999, Journal of neurochemistry.
[44] Marcel Leist,et al. Generation of genetically-modified human differentiated cells for toxicological tests and the study of neurodegenerative diseases. , 2013, ALTEX.
[45] K. Frei,et al. Macrophage‐induced cytotoxicity of N‐methyl‐D‐aspartate receptor positive neurons involves excitatory amino acids rather than reactive oxygen intermediates and cytokines , 1992, European journal of immunology.
[46] Joanna L. Sharman,et al. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands , 2013, Nucleic Acids Res..
[47] T Hartung,et al. Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+ , 2014, Cell Death and Disease.
[48] P. Popovich,et al. Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis , 2014, Neuron.
[49] H. Reichmann,et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice , 2012, Scientific Reports.
[50] Guy C. Brown,et al. Inflammatory Neurodegeneration Mediated by Nitric Oxide from Activated Glia-Inhibiting Neuronal Respiration, Causing Glutamate Release and Excitotoxicity , 2001, The Journal of Neuroscience.
[51] M. Scheffner,et al. Poly(ADP‐ribose)‐mediated interplay of XPA and PARP1 leads to reciprocal regulation of protein function , 2014, The FEBS journal.
[52] Florian Gantner,et al. Phagocytosis of Nonapoptotic Cells Dying by Caspase- Independent Mechanisms1 , 2000, The Journal of Immunology.
[53] P. Mcgeer,et al. Glial reactions in Parkinson's disease , 2008, Movement disorders : official journal of the Movement Disorder Society.
[54] Thomas Gasser,et al. Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling , 2013, PloS one.
[55] Paola Piccini,et al. Priorities in Parkinson's disease research , 2011, Nature Reviews Drug Discovery.
[56] P. Schwartz,et al. Human Pluripotent Stem Cells , 2011, Methods in Molecular Biology.
[57] W. Koh,et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing , 2011, Cell Death and Differentiation.
[58] A. Bürkle,et al. Ex vivo supplementation with nicotinic acid enhances cellular poly(ADP-ribosyl)ation and improves cell viability in human peripheral blood mononuclear cells. , 2010, Biochemical pharmacology.
[59] N. Neff,et al. Neurotrophic 3,9-bis[(alkylthio)methyl]-and-bis(alkoxymethyl)-K-252a derivatives. , 1997, Journal of medicinal chemistry.
[60] J. Schulz,et al. Inhibition of Neuronal Nitric Oxide Synthase by 7‐Nitroindazole Protects Against MPTP‐Induced Neurotoxicity in Mice , 1995, Journal of neurochemistry.
[61] Adam J Pawson,et al. The Concise Guide to Pharmacology 2013/14: Transporters , 2013, British journal of pharmacology.
[62] L. Costa,et al. Astrocytes protect against diazinon- and diazoxon-induced inhibition of neurite outgrowth by regulating neuronal glutathione. , 2014, Toxicology.
[63] Jeppe Falsig,et al. Defined inflammatory states in astrocyte cultures: correlation with susceptibility towards CD95‐driven apoptosis , 2003, Journal of neurochemistry.
[64] V. Tabar,et al. Derivation of midbrain dopamine neurons from human embryonic stem cells. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[65] T. Sugimura,et al. Monoclonal antibodies to poly(adenosine diphosphate ribose) recognize different structures. , 1984, Biochemistry.
[66] T. Südhof,et al. Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells , 2013, Neuron.
[67] M. Leist,et al. Requirement of a dopaminergic neuronal phenotype for toxicity of low concentrations of 1-methyl-4-phenylpyridinium to human cells. , 2009, Toxicology and applied pharmacology.
[68] Scott A Noggle,et al. Differentiation of Human Embryonic Stem Cells to Dopaminergic Neurons in Serum‐Free Suspension Culture , 2004, Stem cells.
[69] M. Fan,et al. Generation of dopaminergic neurons from human fetal mesencephalic progenitors after co-culture with striatal-conditioned media and exposure to lowered oxygen , 2009, Brain Research Bulletin.