A review of errors in multi-frequency EIT instrumentation

Multi-frequency electrical impedance tomography (MFEIT) was proposed over 10 years ago as a potential spectroscopic impedance imaging method. At least seven systems have been developed for imaging the lung, heart, breast and brain, yet none has yet achieved clinical acceptance. While the absolute impedance varies considerably between different tissues, the changes in the spectrum due to physiological changes are expected to be quite small, especially when measured through a volume. This places substantial requirements on the MFEIT instrumentation to maintain a flat system frequency response over a broad frequency range (dc-MHz). In this work, the EIT measurement problem is described from a multi-frequency perspective. Solutions to the common problems are considered from recent MFEIT systems, and the debate over four-terminal or two-terminal (multiple source) architecture is revisited. An analysis of the sources of MFEIT errors identifies the major sources of error as stray capacitance and common-mode voltages which lead to a load dependence in the frequency response of MFEIT systems. A system that employs active electrodes appears to be the most able to cope with these errors (Li et al 1996). A distributed system with digitization at the electrode is suggested as a next step in MFEIT system development.

[1]  Ning Liu,et al.  A multichannel synthesizer and voltmeter for electrical impedance tomography , 2003, Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE Cat. No.03CH37439).

[2]  Mi Wang,et al.  Electrical resistance tomography for process applications , 1996 .

[3]  T. Yamamoto,et al.  Electrical properties of the epidermal stratum corneum. , 1973, Medical & biological engineering.

[4]  D S Holder,et al.  Identification of a suitable current waveform for acute stroke imaging , 2006, Physiological measurement.

[5]  P Record,et al.  Conducting boundary strategy: a new technique for medical EIT. , 1995, Physiological measurement.

[6]  Trevor York Custom silicon for tomographic instrumentation , 1996 .

[7]  Ryan Halter,et al.  Design and implementation of a high frequency electrical impedance tomography system. , 2004, Physiological measurement.

[8]  Lior Horesh,et al.  Specification and calibration of a multi-frequency MEIT system for stroke , 2005 .

[9]  J P Kaipio,et al.  Assessment of errors in static electrical impedance tomography with adjacent and trigonometric current patterns. , 1997, Physiological measurement.

[10]  E. Barsoukov,et al.  Impedance spectroscopy : theory, experiment, and applications , 2005 .

[11]  R Bragós,et al.  A parallel broadband real-time system for electrical impedance tomography. , 1996, Physiological measurement.

[12]  A Korjenevsky,et al.  A 3D electrical impedance tomography (EIT) system for breast cancer detection. , 2001, Physiological measurement.

[13]  K. Boone,et al.  Effect of skin impedance on image quality and variability in electrical impedance tomography: a model study , 1996, Medical and Biological Engineering and Computing.

[14]  Lior Horesh,et al.  Design of electrodes and current limits for low frequency electrical impedance tomography of the brain , 2007, Medical & Biological Engineering & Computing.

[15]  J. Rosell,et al.  Skin impedance from 1 Hz to 1 MHz , 1988, IEEE Transactions on Biomedical Engineering.

[16]  J Kaipio,et al.  Generalized optimal current patterns and electrical safety in EIT. , 2001, Physiological measurement.

[17]  V. Cherepenin,et al.  Three-dimensional EIT imaging of breast tissues: system design and clinical testing , 2002, IEEE Transactions on Medical Imaging.

[18]  H Griffiths,et al.  Systematic errors in multi-frequency EIT. , 2000, Physiological measurement.

[19]  Brian H. Brown,et al.  Design of a phase-sensitive detector to maximize signal-to-noise ratio in the presence of Gaussian wideband noise , 1992 .

[20]  P Rolfe,et al.  Analysis and assessment of errors in a parallel data acquisition system for electrical impedance tomography. , 1988, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[21]  Gerhard Hellige,et al.  Distribution of lung ventilation in spontaneously breathing neonates lying in different body positions , 2003, Intensive Care Medicine.

[22]  Gary J Saulnier,et al.  A high-precision voltage source for EIT. , 2006, Physiological measurement.

[23]  J P Morucci,et al.  A multifrequency serial EIT system. , 1996, Physiological measurement.

[24]  D. S. Holder,et al.  Assessment of noise and drift artefacts in electrical impedance tomography measurements using the sheffield Mark I system , 1995 .

[25]  R H Bayford,et al.  Bioimpedance tomography (electrical impedance tomography). , 2006, Annual review of biomedical engineering.

[26]  P. Hua,et al.  Using compound electrodes in electrical impedance tomography , 1993, IEEE Transactions on Biomedical Engineering.

[27]  B. Rigaud,et al.  Experimental acquisition system for impedance tomography with active electrode approach , 2006, Medical and Biological Engineering and Computing.

[28]  D. Isaacson Distinguishability of Conductivities by Electric Current Computed Tomography , 1986, IEEE Transactions on Medical Imaging.

[29]  Lior Horesh,et al.  Stroke type differentiation by multi-frequency electrical impedance tomography—a feasibility study , 2005 .

[30]  R H Bayford,et al.  Design and performance of the UCLH mark 1b 64 channel electrical impedance tomography (EIT) system, optimized for imaging brain function. , 2002, Physiological measurement.

[31]  U Faust,et al.  Fast EIT data acquisition system with active electrodes and its application to cardiac imaging. , 1996, Physiological measurement.

[32]  H Scharfetter,et al.  A model of artefacts produced by stray capacitance during whole body or segmental bioimpedance spectroscopy. , 1998, Physiological measurement.

[33]  T E Kerner,et al.  An improved data acquisition method for electrical impedance tomography. , 2001, Physiological measurement.

[34]  C. Davis,et al.  Impedance spectroscopy of human erythrocytes: system calibration, and nonlinear modeling , 1993, IEEE Transactions on Biomedical Engineering.

[35]  J. Rosell,et al.  Multi-frequency static imaging in electrical impedance tomography: Part 1 instrumentation requirements , 1995, Medical and Biological Engineering and Computing.

[36]  Lior Horesh,et al.  Characterisation of an EIT system for acute stroke imaging in patients with brain tumours, arteriovenous malformations and chronic stroke , 2005 .

[37]  F al-Hatib,et al.  Patient-instrument connection errors in bioelectrical impedance measurement , 1998, Physiological measurement.

[38]  D S Holder,et al.  Current approaches to analogue instrumentation design in electrical impedance tomography , 1996, Physiological measurement.

[39]  José Hinz,et al.  Regional ventilation by electrical impedance tomography: a comparison with ventilation scintigraphy in pigs. , 2003, Chest.

[40]  Richard H. Bayford,et al.  A comparison of techniques to optimize measurement of voltage changes in electrical impedance tomography by minimizing phase shift errors , 2002, IEEE Transactions on Medical Imaging.

[41]  Alexander S Ross,et al.  Current source design for electrical impedance tomography. , 2003, Physiological measurement.

[42]  Richard H. Bayford,et al.  Three-Dimensional Electrical Impedance Tomography of Human Brain Activity , 2001, NeuroImage.

[43]  T C Pilkington,et al.  Comments on distinguishability in electrical impedance imaging. , 1993, IEEE transactions on bio-medical engineering.

[44]  Lior Horesh,et al.  Some novel approaches large scale algorithms for multi-frequency electrical impedance tomography of the human head , 2006 .

[45]  B H Brown,et al.  Electrical impedance tomography (EIT): a review , 2003, Journal of medical engineering & technology.

[46]  Keith D. Paulsen,et al.  Simulation of error propagation in finite element image reconstruction for electrical impedance tomography , 2001 .

[47]  G.J. Saulnier,et al.  ACT3: a high-speed, high-precision electrical impedance tomograph , 1991, IEEE Transactions on Biomedical Engineering.

[48]  C D Binnie,et al.  Factors limiting the application of electrical impedance tomography for identification of regional conductivity changes using scalp electrodes during epileptic seizures in humans , 2006, Physiological measurement.

[49]  R H Smallwood,et al.  Mk3.5: a modular, multi-frequency successor to the Mk3a EIS/EIT system. , 2001, Physiological measurement.

[50]  Hamid Dehghani,et al.  A novel data calibration scheme for electrical impedance tomography. , 2003, Physiological measurement.

[51]  R Bayford,et al.  Design and calibration of a compact multi-frequency EIT system for acute stroke imaging. , 2006, Physiological measurement.

[52]  Keith D. Paulsen,et al.  A Broadband High-Frequency Electrical Impedance Tomography System for Breast Imaging , 2008, IEEE Transactions on Biomedical Engineering.

[53]  J Rosell,et al.  Common-mode feedback in electrical impedance tomography. , 1992, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[54]  D. Isaacson,et al.  Errors due to measuring voltage on current-carrying electrodes in electric current computed tomography , 1990, IEEE Transactions on Biomedical Engineering.

[55]  G. Hellige,et al.  End-expiratory lung impedance change enables bedside monitoring of end-expiratory lung volume change , 2002, Intensive Care Medicine.

[56]  H. McCann,et al.  Subsecond observations of EIT voltage changes on the human scalp due to brain stimulus , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.