An Implantable Pressure Sensing System With Electromechanical Interrogation Scheme

In this paper, we report on the development of an implantable pressure sensing system that is powered by mechanical vibrations in the audible acoustic frequency range. This technique significantly enhances interrogation range, alleviates the misalignment issues commonly encountered with inductive powering, and simplifies the external receiver circuitry. The interrogation scheme consists of two phases: a mechanical vibration phase and an electrical radiation phase. During the first phase, a piezoelectric cantilever acts as an acoustic receiver and charges a capacitor by converting sound vibration harmonics occurring at its resonant frequency into electrical power. In the subsequent electrical phase, when the cantilever is not vibrating, the stored electric charge is discharged across an LC tank whose inductor is pressure sensitive; hence, when the LC tank oscillates at its natural resonant frequency, it radiates a high-frequency signal that is detectable using an external receiver and its frequency corresponds to the measured pressure. The pressure sensitive inductor consists of a planar coil (single loop of wire) with a ferrite core whose distance to the coil varies with applied pressure. A prototype of the implantable pressure sensor is fabricated and tested, both in vitro and in vivo (swine bladder). A pressure sensitivity of 1 kHz/cm $H_{2}$O is achieved with minimal misalignment sensitivity (26% drop at 90° misalignment between the implanted device and acoustic source; 60% drop at 90° misalignment between the implanted device and RF receiver coil).

[1]  David E. Culler,et al.  Design of a wireless sensor network platform for detecting rare, random, and ephemeral events , 2005, IPSN 2005. Fourth International Symposium on Information Processing in Sensor Networks, 2005..

[2]  W. Ko,et al.  Intracranial Pressure Telemetry System Using Semicustom Integrated Circuits , 1986, IEEE Transactions on Biomedical Engineering.

[3]  P. Swain,et al.  Wireless capsule endoscopy. , 2002, The Israel Medical Association journal : IMAJ.

[4]  Eli Fromm A Thick-Film Hybrid Implantable Telemeter , 1983, Engineering in Medicine and Biology Magazine.

[5]  L. Stevenson,et al.  Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial , 2011, The Lancet.

[6]  K. Wise,et al.  AN INTRAOCULAR PRESSURE SENSOR BASED ON A GLASS REFLOW PROCESS , 2010 .

[7]  B.J. Hosticka,et al.  A programmable intraocular CMOS pressure sensor system implant , 2001, Proceedings of the 26th European Solid-State Circuits Conference.

[8]  Wan Y. Shih,et al.  Effect of length, width, and mode on the mass detection sensitivity of piezoelectric unimorph cantilevers , 2002 .

[9]  C. Zierhofer,et al.  Electronic design of a cochlear implant for multichannel high-rate pulsatile stimulation strategies , 1995 .

[10]  Mark J. Schroeder,et al.  An Analysis on the Role of Water Content and State on Effective Permittivity Using Mixing Formulas , 2008 .

[11]  W.J. Heetderks,et al.  RF powering of millimeter- and submillimeter-sized neural prosthetic implants , 1988, IEEE Transactions on Biomedical Engineering.

[12]  M. Allen,et al.  Micromachined endovascularly-implantable wireless aneurysm pressure sensors: from concept to clinic , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[13]  Babak Ziaie,et al.  A Minimally Invasive Implantable Wireless Pressure Sensor for Continuous IOP Monitoring , 2011, IEEE Transactions on Biomedical Engineering.

[14]  Ying Yao,et al.  An Implantable 64-Channel Wireless Microsystem for Single-Unit Neural Recording , 2009, IEEE Journal of Solid-State Circuits.

[15]  Wen H. Ko,et al.  Single Frequency RF Powered ECG Telemetry System , 1979, IEEE Transactions on Biomedical Engineering.

[16]  M. Fall,et al.  The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. , 2002, American journal of obstetrics and gynecology.

[17]  K. Najafi,et al.  A wireless batch sealed absolute capacitive pressure sensor , 2001 .

[18]  Jan M. Rabaey,et al.  Improving power output for vibration-based energy scavengers , 2005, IEEE Pervasive Computing.

[19]  W. Ko,et al.  Design of radio-frequency powered coils for implant instruments , 1977, Medical and Biological Engineering and Computing.

[20]  James D. Meindl,et al.  Integrated Circuit Implantable Telemetry Systems , 1983, Engineering in Medicine and Biology Magazine.

[21]  Zoubir Hamici,et al.  A high-efficiency power and data transmission system for biomedical implanted electronic devices , 1996 .

[22]  R B Robrock,et al.  Six channel physiological telemetry system. , 1967, IEEE transactions on bio-medical engineering.

[23]  Babak Ziaie,et al.  A FERROFLUID-BASED PRESSURE SENSOR FOR BIOMEDICAL APPLICATIONS , 2012 .

[24]  Babak Ziaie,et al.  An Ultrasonically Powered Implantable Micro-Oxygen Generator (IMOG) , 2011, IEEE Transactions on Biomedical Engineering.

[25]  R. Stuart Mackay Radio Telemetering from Within the Human Body , 1959 .

[26]  Po-Jen Shih,et al.  Design, fabrication, and application of bio-implantable acoustic power transmission , 2010, Journal of Microelectromechanical Systems.