Multi‐slice computed tomography characteristics of solitary pulmonary ground‐glass nodules: Differences between malignant and benign

Ground‐glass nodules (GGNs), which are possible precursors of lung cancer, attract increasing attention. Many studies have attempted to identify the characteristic imaging features of GGNs for their qualitative diagnosis; however, the comprehension of GGNs remains controversial. We performed this study to identify imaging characteristics helpful to the differential diagnosis of solitary GGNs.

[1]  L. Fan,et al.  Multidetector CT features of pulmonary focal ground-glass opacity: differences between benign and malignant. , 2012, The British journal of radiology.

[2]  M. Chung,et al.  Solid or partly solid solitary pulmonary nodules: their characterization using contrast wash-in and morphologic features at helical CT. , 2007, Chest.

[3]  M. Mascalchi,et al.  Lung Cancer Associated With Cystic Airspaces , 2015, Journal of computer assisted tomography.

[4]  Jun Wang,et al.  Development and validation of a clinical prediction model to estimate the probability of malignancy in solitary pulmonary nodules in Chinese people. , 2011, Clinical lung cancer.

[5]  H. Ji,et al.  Spectrum of LKB1, EGFR, and KRAS Mutations in Chinese Lung Adenocarcinomas , 2010, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[6]  M Fujita,et al.  Prevalence of air bronchograms in small peripheral carcinomas of the lung on thin-section CT: comparison with benign tumors. , 1991, AJR. American journal of roentgenology.

[7]  Jianxing He,et al.  Size of solitary pulmonary nodule was the risk factor of malignancy. , 2014, Journal of thoracic disease.

[8]  M. Wahidi,et al.  Evidence for the treatment of patients with pulmonary nodules: when is it lung cancer?: ACCP evidence-based clinical practice guidelines (2nd edition). , 2007, Chest.

[9]  Charles A Powell,et al.  International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. , 2011, Proceedings of the American Thoracic Society.

[10]  O. Miettinen,et al.  CT screening for lung cancer: frequency and significance of part-solid and nonsolid nodules. , 2002, AJR. American journal of roentgenology.

[11]  Ugo Pastorino,et al.  Current status of lung cancer screening. , 2013, Thoracic surgery clinics.

[12]  J. Austin,et al.  Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. , 1996, Radiology.

[13]  E G Theros,et al.  1976 Caldwell Lecture: varying manifestation of peripheral pulmonary neoplasms: a radiologic-pathologic correlative study. , 1977, AJR. American journal of roentgenology.

[14]  Y. Shim,et al.  Persistent pulmonary nodular ground-glass opacity at thin-section CT: histopathologic comparisons. , 2007, Radiology.

[15]  M. Raica,et al.  Assessement of angiogenesis reveals blood vessel heterogeneity in lung carcinoma. , 2012, Oncology letters.

[16]  S S Sagel,et al.  CT of the pulmonary nodule: a cooperative study. , 1986, Radiology.

[17]  E. Davis,et al.  The solitary pulmonary nodule. , 1964, The Medical annals of the District of Columbia.

[18]  J. Rathmell,et al.  Results of the two incidence screenings in the National Lung Screening Trial. , 2013, The New England journal of medicine.

[19]  J. Ikezoe,et al.  Focal organizing pneumonia: CT appearance. , 1993, Radiology.

[20]  S. Raoof,et al.  A practical algorithmic approach to the diagnosis and management of solitary pulmonary nodules: part 1: radiologic characteristics and imaging modalities. , 2013, Chest.

[21]  J. Folkman What is the evidence that tumors are angiogenesis dependent? , 1990, Journal of the National Cancer Institute.

[22]  D. Carney,et al.  Update on anti-angiogenic therapy in non-small cell lung cancer: Are we making progress? , 2011, Journal of thoracic disease.

[23]  Kathleen Brown,et al.  Lung Cancer Staging: Clinical and Radiologic Perspectives , 2013, Seminars in Interventional Radiology.

[24]  T. Araki,et al.  Focal area of ground-glass opacity and ground-glass opacity predominance on thin-section CT: discrimination between neoplastic and non-neoplastic lesions. , 2006, Clinical radiology.

[25]  Tae Jung Kim,et al.  Clinical significance of a solitary ground-glass opacity (GGO) lesion of the lung detected by chest CT. , 2007, Lung cancer.

[26]  D. Ost,et al.  Clinical practice. The solitary pulmonary nodule. , 2003, The New England journal of medicine.

[27]  Kenji Eguchi,et al.  Focal ground-glass opacity detected by low-dose helical CT. , 2002, Chest.

[28]  N. Müller,et al.  Fleischner Society: glossary of terms for thoracic imaging. , 2008, Radiology.

[29]  Y. Sakao,et al.  Subtypes of peripheral adenocarcinoma of the lung: differentiation by thin-section CT , 2005, European Radiology.

[30]  Elisabeth Brambilla,et al.  The 2004 World Health Organization classification of lung tumors. , 2005, Seminars in roentgenology.

[31]  T. Mochizuki,et al.  Pulmonary lesions detected in population-based CT screening for lung cancer: reliable findings of benign lesions. , 2004, Radiation medicine.

[32]  N. Müller,et al.  Solitary pulmonary nodule: high-resolution CT and radiologic-pathologic correlation. , 1991, Radiology.

[33]  F. Grosveld,et al.  Distal angiogenesis: a new concept for lung vascular morphogenesis. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[34]  K. Doi,et al.  Malignant versus benign nodules at CT screening for lung cancer: comparison of thin-section CT findings. , 2004, Radiology.

[35]  D. Ost,et al.  Solitary Pulmonary Nodule , 2005 .

[36]  A. Blandino,et al.  Radiolucencies and cavitation in bronchioloalveolar carcinoma: CT-pathologic correlation , 1999, European Radiology.

[37]  Ryutaro Kakinuma,et al.  Localized Pure Ground-Glass Opacity on High-Resolution CT: Histologic Characteristics , 2002, Journal of computer assisted tomography.

[38]  M Fujita,et al.  CT-pathologic correlation in small peripheral lung cancers. , 1987, AJR. American journal of roentgenology.

[39]  K. Mori,et al.  Small nodular lesions in the lung periphery: new approach to diagnosis with CT. , 1990, Radiology.

[40]  O. Miettinen,et al.  Early Lung Cancer Action Project: overall design and findings from baseline screening , 1999, The Lancet.