Lyme borreliosis vaccination: the facts, the challenge, the future.

[1]  M. Villar,et al.  Characterization of ferritin 2 for the control of tick infestations. , 2010, Vaccine.

[2]  P. Mead,et al.  Lyme borreliosis in dogs and humans in the USA. , 2010, Trends in parasitology.

[3]  T. Warner,et al.  One-Year Duration of Immunity Induced by Vaccination with a Canine Lyme Disease Bacterin , 2010, Clinical and Vaccine Immunology.

[4]  R. Schumann,et al.  Chemoenzymatic synthesis of a glycolipid library and elucidation of the antigenic epitope for construction of a vaccine against Lyme disease. , 2010, Chemistry.

[5]  E. Fikrig,et al.  Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent. , 2009, Cell host & microbe.

[6]  J. Frère,et al.  Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis , 2009, The Journal of experimental medicine.

[7]  U. Pal,et al.  BB0323 function is essential for Borrelia burgdorferi virulence and persistence through tick-rodent transmission cycle. , 2009, The Journal of infectious diseases.

[8]  C. Mannella,et al.  The bactericidal effect of a complement-independent antibody is osmolytic and specific to Borrelia , 2009, Proceedings of the National Academy of Sciences.

[9]  E. Park,et al.  Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations , 2009, BMC biotechnology.

[10]  R. Brasseur,et al.  Exosites mediate the anti‐inflammatory effects of a multifunctional serpin from the saliva of the tick Ixodes ricinus , 2009, The FEBS journal.

[11]  U. Göbel,et al.  Acylated Cholesteryl Galactosides Are Specific Antigens of Borrelia Causing Lyme Disease and Frequently Induce Antibodies in Late Stages of Disease , 2009, Journal of Biological Chemistry.

[12]  B. Stevenson,et al.  Borrelia burgdorferi RevA Antigen Binds Host Fibronectin , 2009, Infection and Immunity.

[13]  M. Villar,et al.  Conservation and immunogenicity of the mosquito ortholog of the tick-protective antigen, subolesin , 2009, Parasitology Research.

[14]  I. Sauman,et al.  Knockdown of proteins involved in iron metabolism limits tick reproduction and development , 2009, Proceedings of the National Academy of Sciences.

[15]  T. Warner,et al.  Bacterin That Induces Anti-OspA and Anti-OspC Borreliacidal Antibodies Provides a High Level of Protection against Canine Lyme Disease , 2008, Clinical and Vaccine Immunology.

[16]  P. Zipfel,et al.  Borrelia burgdorferi Infection-Associated Surface Proteins ErpP, ErpA, and ErpC Bind Human Plasminogen , 2008, Infection and Immunity.

[17]  J. Andersen,et al.  Cutting Edge: Immunity against a “Silent” Salivary Antigen of the Lyme Vector Ixodes scapularis Impairs Its Ability to Feed1 , 2008, The Journal of Immunology.

[18]  Sean P. Riley,et al.  Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection. , 2008, International journal of medical microbiology : IJMM.

[19]  E. Fikrig,et al.  The Tick Salivary Protein Salp15 Inhibits the Killing of Serum-Sensitive Borrelia burgdorferi Sensu Lato Isolates , 2008, Infection and Immunity.

[20]  L. Vanhamme,et al.  The impact of gene knock-down and vaccination against salivary metalloproteases on blood feeding and egg laying by Ixodes ricinus. , 2008, International journal for parasitology.

[21]  E. Fikrig,et al.  Salivating for Knowledge: Potential Pharmacological Agents in Tick Saliva , 2008, PLoS medicine.

[22]  T. van der Poll,et al.  Salp15 Binding to DC-SIGN Inhibits Cytokine Expression by Impairing both Nucleosome Remodeling and mRNA Stabilization , 2008, PLoS pathogens.

[23]  M. Nassal,et al.  Development of hepatitis B virus capsids into a whole-chain protein antigen display platform: new particulate Lyme disease vaccines. , 2008, International journal of medical microbiology : IJMM.

[24]  R. Nadelman,et al.  Reinfection in patients with Lyme disease. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[25]  E. Fikrig,et al.  Tick-host-pathogen interactions in Lyme borreliosis. , 2007, Trends in parasitology.

[26]  E. Fikrig,et al.  Biochemical and Functional Characterization of Salp20, an Ixodes scapularis Tick Salivary Protein that Inhibits the Complement Pathway , 2007, Insect molecular biology.

[27]  B. Sukumaran,et al.  A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector. , 2007, Cell host & microbe.

[28]  Thomas E. Royce,et al.  Immunity against Ixodes scapularis Salivary Proteins Expressed within 24 Hours of Attachment Thwarts Tick Feeding and Impairs Borrelia Transmission , 2007, PloS one.

[29]  L. Vanhamme,et al.  Protective immunity against Ixodes ricinus induced by a salivary serpin. , 2007, Vaccine.

[30]  P. Sharp,et al.  Ixodes ticks belonging to the Ixodes ricinus complex encode a family of anticomplement proteins , 2007, Insect molecular biology.

[31]  E. Buckles,et al.  Development of an OspC-based tetravalent, recombinant, chimeric vaccinogen that elicits bactericidal antibody against diverse Lyme disease spirochete strains. , 2007, Vaccine.

[32]  R. Straubinger,et al.  Characterization of the humoral immune response in dogs after vaccination against the Lyme borreliosis agent A study with five commercial vaccines using two different vaccination schedules. , 2007, Vaccine.

[33]  R. Brasseur,et al.  Anti-hemostatic Effects of a Serpin from the Saliva of the Tick Ixodes ricinus* , 2006, Journal of Biological Chemistry.

[34]  J. Andersen,et al.  Antiinflammatory and Immunosuppressive Activity of Sialostatin L, a Salivary Cystatin from the Tick Ixodes scapularis* , 2006, Journal of Biological Chemistry.

[35]  J. Fuente,et al.  Reduction of tick infections with Anaplasma marginale and A. phagocytophilum by targeting the tick protective antigen subolesin , 2006, Parasitology Research.

[36]  Manoj N. Krishnan,et al.  An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands , 2006, The Journal of experimental medicine.

[37]  R. Hails,et al.  An Antivector Vaccine Protects against a Lethal Vector-Borne Pathogen , 2006, PLoS pathogens.

[38]  T. van der Poll,et al.  Two-way interactions between inflammation and coagulation. , 2005, Trends in cardiovascular medicine.

[39]  R. Hails,et al.  A cross-reactive tick cement antigen is a candidate broad-spectrum tick vaccine. , 2005, Vaccine.

[40]  R. Koski,et al.  The Lyme disease agent exploits a tick protein to infect the mammalian host , 2005, Nature.

[41]  Emily S. Reisenbichler,et al.  Multicomponent Lyme vaccine: three is not a crowd. , 2005, Vaccine.

[42]  S. Telford,et al.  Hypersensitivity to Ticks and Lyme Disease Risk , 2005, Emerging infectious diseases.

[43]  Ruth R. Montgomery,et al.  TROSPA, an Ixodes scapularis Receptor for Borrelia burgdorferi , 2004, Cell.

[44]  H. Barrios,et al.  Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac TM , 2004, Experimental & Applied Acarology.

[45]  E. Fikrig,et al.  Borrelia burgdorferi Changes Its Surface Antigenic Expression in Response to Host Immune Responses , 2004, Infection and Immunity.

[46]  M. Molento,et al.  Tick control: an industry point of view , 2004, Parasitology.

[47]  E. Fikrig,et al.  OspB Antibody Prevents Borrelia burgdorferi Colonization of Ixodes scapularis , 2004, Infection and Immunity.

[48]  Francesco Saverio Tedesco,et al.  Serum-Resistant Strains of Borrelia burgdorferi Evade Complement-Mediated Killing by Expressing a CD59-Like Complement Inhibitory Molecule1 , 2003, The Journal of Immunology.

[49]  R. Koski,et al.  A novel family of anticoagulants from the saliva of Ixodes scapularis , 2002, Insect molecular biology.

[50]  E. Fikrig,et al.  Molecular Adaptation of Borrelia burgdorferi in the Murine Host , 2002, The Journal of experimental medicine.

[51]  E. Fikrig,et al.  Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice , 2002, Nature Medicine.

[52]  E. Fikrig,et al.  Salp15, an ixodes scapularis salivary protein, inhibits CD4(+) T cell activation. , 2002, Immunity.

[53]  J. Andersen,et al.  Ixolaris, a novel recombinant tissue factor pathway inhibitor (TFPI) from the salivary gland of the tick, Ixodes scapularis: identification of factor X and factor Xa as scaffolds for the inhibition of factor VIIa/tissue factor complex. , 2002, Blood.

[54]  Y. Belkaid,et al.  Toward a Defined Anti-Leishmania Vaccine Targeting Vector Antigens , 2001, The Journal of experimental medicine.

[55]  M. Hanson,et al.  Evidence for Vaccine Synergy between Borrelia burgdorferi Decorin Binding Protein A and Outer Surface Protein A in the Mouse Model of Lyme Borreliosis , 2000, Infection and Immunity.

[56]  J. Radolf,et al.  Decorin-Binding Protein A (DbpA) of Borrelia burgdorferi Is Not Protective When Immunized Mice Are Challenged via Tick Infestation and Correlates with the Lack of DbpA Expression by B. burgdorferi in Ticks , 2000, Infection and Immunity.

[57]  E. Fikrig,et al.  Arthropod- and Host-Specific Borrelia burgdorferi bbk32 Expression and the Inhibition of Spirochete Transmission1 , 2000, The Journal of Immunology.

[58]  D. Dennis,et al.  Surveillance for Lyme disease--United States, 1992-1998. , 2000, MMWR. CDC surveillance summaries : Morbidity and mortality weekly report. CDC surveillance summaries.

[59]  T. Schwan,et al.  Temporal Changes in Outer Surface Proteins A and C of the Lyme Disease-Associated Spirochete, Borrelia burgdorferi, during the Chain of Infection in Ticks and Mice , 2000, Journal of Clinical Microbiology.

[60]  P. Nuttall,et al.  Immunoglobulin-binding proteins in ticks: new target for vaccine development against a blood-feeding parasite , 1999, Cellular and Molecular Life Sciences CMLS.

[61]  Barbara J. B. Johnson,et al.  Identification of a 47 kDa fibronectin‐binding protein expressed by Borrelia burgdorferi isolate B31 , 1998, Molecular microbiology.

[62]  C. Schmid,et al.  Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. , 1998, The New England journal of medicine.

[63]  E. Fikrig,et al.  Prevention of Borrelia burgdorferi transmission in guinea pigs by tick immunity. , 1998, The American journal of tropical medicine and hygiene.

[64]  B. P. Guo,et al.  Active and Passive Immunity against Borrelia burgdorferi Decorin Binding Protein A (DbpA) Protects against Infection , 1998, Infection and Immunity.

[65]  S. Norris,et al.  Antigenic Variation in Lyme Disease Borreliae by Promiscuous Recombination of VMP-like Sequence Cassettes , 1997, Cell.

[66]  T. Burkot,et al.  Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks , 1997, Infection and immunity.

[67]  T. Burkot,et al.  Outer surface protein C (OspC), but not P39, is a protective immunogen against a tick-transmitted Borrelia burgdorferi challenge: evidence for a conformational protective epitope in OspC , 1996, Infection and immunity.

[68]  E. Fikrig,et al.  Borrelia burgdorferi OspA is an arthropod-specific transmission- blocking Lyme disease vaccine , 1996, The Journal of experimental medicine.

[69]  E. Fikrig,et al.  Evasion of protective immunity by Borrelia burgdorferi by truncation of outer surface protein B. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[70]  E. Fikrig,et al.  Long-term protection of mice from Lyme disease by vaccination with OspA , 1992, Infection and immunity.

[71]  E. Fikrig,et al.  Roles of OspA, OspB, and flagellin in protective immunity to Lyme borreliosis in laboratory mice , 1992, Infection and immunity.

[72]  D. Fish,et al.  Evaluation of host-targeted acaricide for reducing risk of Lyme disease in southern New York state. , 1991, Journal of medical entomology.

[73]  F. Markwardt,et al.  Isolation and characterization of a thrombin inhibitor from the tick ixodes ricinus. , 1991, Die Pharmazie.

[74]  Gary J. Nabel,et al.  New Generation Vaccines , 1990 .

[75]  S. Wikel,et al.  Resistance to tick-borne Francisella tularensis by tick-sensitized rabbits: allergic klendusity. , 1979, The American journal of tropical medicine and hygiene.

[76]  W. Trager.  Acquired Immunity to Ticks. , 1939 .

[77]  K. K. Clark,et al.  Infection Rates in Dogs Vaccinated and Not Vaccinated With an OspA Borrelia burgdorferi Vaccine in a Lyme Disease-Endemic Area of Connecticut , 2005 .

[78]  A. Azad,et al.  Kinetics of ingested host immunoglobulin G in hemolymph and whole body homogenates during nymphal development of Dermacentor variabilis and Ixodes scapularis ticks (Acari: Ixodidae). , 2004, Experimental & Applied Acarology.

[79]  H. Barrios,et al.  Integrated control of Boophilus microplus ticks in Cuba based on vaccination with the anti-tick vaccine Gavac TM , 2004, Experimental & Applied Acarology.

[80]  D. Fish,et al.  Suppression of Acute Ixodes scapularis-Induced Borrelia burgdorferi Infection using Tumor Necrosis Factor-α, Interleukin-2, and Interferon-γ , 1996 .

[81]  D. Fish,et al.  Reduction of nymphal Ixodes dammini (Acari: Ixodidae) in a residential suburban landscape by area application of insecticides. , 1993, Journal of medical entomology.