Tissue engineering strategies for the future generation of dental implants.

[1]  R. Short,et al.  Synthetic implant surfaces. 1. The formation and characterization of sol-gel titania films. , 1996, Biomaterials.

[2]  Matthew J Dalby,et al.  Nucleus alignment and cell signaling in fibroblasts: response to a micro-grooved topography. , 2003, Experimental cell research.

[3]  J. Moradian-Oldak,et al.  Effects of amelogenin on the transforming surface microstructures of Bioglass in a calcifying solution. , 2000, Journal of biomedical materials research.

[4]  S. Henry,et al.  Local Antibacterial Therapy for the Management of Orthopaedic Infections , 1995, Clinical pharmacokinetics.

[5]  A. Edidin,et al.  A 10-year minimum follow-up of hydroxyapatite-coated threaded cups: clinical, radiographic and survivorship analyses with comparison to the literature. , 2003, The Journal of arthroplasty.

[6]  T. Diekwisch,et al.  Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development. , 1993, Development.

[7]  J. Moradian-Oldak,et al.  Modulation of apatite crystal growth on Bioglass by recombinant amelogenin. , 1999, Biomaterials.

[8]  T. Albrektsson.  Direct bone anchorage of dental implants. , 1983, The Journal of prosthetic dentistry.

[9]  F Sutter,et al.  The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. , 1981, Journal of maxillofacial surgery.

[10]  G. Falini,et al.  Supramolecular Assembly of Amelogenin Nanospheres into Birefringent Microribbons , 2005, Science.

[11]  C. Damsky,et al.  Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis , 1998, The Journal of cell biology.

[12]  R. Midura,et al.  Biomedical Implant Surface Topography and Its Effects on Osteoblast Differentiation In Vitro , 2003 .

[13]  Panjian Li,et al.  Biomimetic nano-apatite coating capable of promoting bone ingrowth. , 2003, Journal of biomedical materials research. Part A.

[14]  N. Araki,et al.  Calcium hydroxyapatite ceramic used as a delivery system for antibiotics. , 1992, The Journal of bone and joint surgery. British volume.

[15]  M. Solursh.  Formation of cartilage tissue in vitro , 1991, Journal of cellular biochemistry.

[16]  D. Puleo,et al.  Osteoblast responses to orthopedic implant materials in vitro. , 1991, Journal of biomedical materials research.

[17]  P. Yelick,et al.  Tissue Engineering of Complex Tooth Structures on Biodegradable Polymer Scaffolds , 2002, Journal of dental research.

[18]  L. Hammarström.  Enamel matrix, cementum development and regeneration. , 1997, Journal of clinical periodontology.

[19]  P C Amadio,et al.  Repetitive stress injury. , 2001, The Journal of bone and joint surgery. American volume.

[20]  C. Stanford,et al.  Significant role of adhesion properties of primary osteoblast-like cells in early adhesion events for chondroitin sulfate and dermatan sulfate surface molecules. , 1999, Journal of biomedical materials research.

[21]  D. Taber,et al.  Quantifying Publication Impact , 2005, Science.

[22]  J. Moradian-Oldak,et al.  Modification of calcium-phosphate coatings on titanium by recombinant amelogenin. , 2003, Journal of biomedical materials research. Part A.

[23]  H. Prydz,et al.  A synthetic, chemically modified ribozyme eliminates amelogenin, the major translation product in developing mouse enamel in vivo. , 1995, The EMBO journal.

[24]  J. Wozney,et al.  Effect of recombinant human bone morphogenetic protein-2/absorbable collagen sponge (rhBMP-2/ACS) on healing in 3-wall intrabony defects in dogs. , 2002, Journal of periodontology.

[25]  A. Kulkarni,et al.  Amelogenin-deficient Mice Display an Amelogenesis Imperfecta Phenotype* , 2001, The Journal of Biological Chemistry.

[26]  S. Bae,et al.  Both the Smad and p38 MAPK pathways play a crucial role in Runx2 expression following induction by transforming growth factor-β and bone morphogenetic protein , 2002, Oncogene.

[27]  C. G. Groot,et al.  Histological and biochemical evaluation of osteoblasts cultured on bioactive glass, hydroxylapatite, titanium alloy, and stainless steel. , 1993, Journal of biomedical materials research.

[28]  S. Haskill,et al.  Signal transduction from the extracellular matrix , 1993, The Journal of cell biology.

[29]  P. C. Rieke,et al.  Innovative materials processing strategies: a biomimetic approach. , 1992, Science.

[30]  C. Lohmann,et al.  Response of MG63 osteoblast-like cells to titanium and titanium alloy is dependent on surface roughness and composition. , 1998, Biomaterials.

[31]  C. Stanford,et al.  Bone Cell Expression on Titanium Surfaces is Altered by Sterilization Treatments , 1994, Journal of dental research.

[32]  Pierre Layrolle,et al.  Bone morphogenetic protein 2 incorporated into biomimetic coatings retains its biological activity. , 2004, Tissue engineering.

[33]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[34]  H. Slavkin,et al.  Amelogenin post-secretory processing during biomineralization in the postnatal mouse molar tooth. , 1991, Archives of oral biology.

[35]  W. Lacefield.  Current status of ceramic coatings for dental implants. , 1998, Implant dentistry.

[36]  L. Bonewald,et al.  Maturation State Determines the Response of Osteogenic Cells to Surface Roughness and 1,25‐Dihydroxyvitamin D3 , 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  D. Seabold,et al.  Implant Surface Roughness Affects Osteoblast Gene Expression , 2003, Journal of dental research.

[38]  J. Corbeil,et al.  Large-scale gene expression analysis of osteoblasts cultured on three different Ti-6Al-4V surface treatments. , 2002, Biomaterials.

[39]  T. Albrektsson,et al.  Optimum surface properties of oxidized implants for reinforcement of osseointegration: surface chemistry, oxide thickness, porosity, roughness, and crystal structure. , 2005, The International journal of oral & maxillofacial implants.

[40]  K. Burridge,et al.  Formation of focal adhesions by osteoblasts adhering to different substrata. , 1994, Experimental cell research.

[41]  J. Moradian-Oldak,et al.  Elongated Growth of Octacalcium Phosphate Crystals in Recombinant Amelogenin Gels under Controlled Ionic Flow , 2002 .

[42]  D. Seabold,et al.  Differentiation of preosteoblasts is affected by implant surface microtopographies. , 2004, Journal of biomedical materials research. Part A.

[43]  D Buser,et al.  Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. , 1991, Journal of biomedical materials research.

[44]  R. Midura,et al.  A rat osteogenic cell line (UMR 106-01) synthesizes a highly sulfated form of bone sialoprotein. , 1990, The Journal of biological chemistry.

[45]  Ziv Simon,et al.  Biomimetic dental implants--new ways to enhance osseointegration. , 2002, Journal.

[46]  K. Miyazono,et al.  Stimulation of Smad1 Transcriptional Activity by Ras‐Extracellular Signal‐Regulated Kinase Pathway: A Possible Mechanism for Collagen‐Dependent Osteoblastic Differentiation , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  J. Moradian-Oldak,et al.  Apatite/Amelogenin Coating on Titanium Promotes Osteogenic Gene Expression , 2005, Journal of dental research.

[48]  J. Kirkham,et al.  The developing enamel matrix: nature and function. , 1998, European journal of oral sciences.

[49]  J. Ellingsen,et al.  A study on the mechanism of protein adsorption to TiO2. , 1991, Biomaterials.

[50]  C. Johansson,et al.  Enamel matrix derivative and titanium implants: An experimental pilot study in the rabbit , 2003 .

[51]  T. Mohandas,et al.  Human and mouse amelogenin gene loci are on the sex chromosomes. , 1989, Genomics.

[52]  J. Wozney,et al.  Delivering on the promise of bone morphogenetic proteins. , 2001, Trends in biotechnology.

[53]  P. Wollan,et al.  Use of alendronate in peri-implant defect regeneration. , 1999, Journal of periodontology.

[54]  G. Xiao,et al.  Bone Morphogenetic Proteins, Extracellular Matrix, and Mitogen‐Activated Protein Kinase Signaling Pathways Are Required for Osteoblast‐Specific Gene Expression and Differentiation in MC3T3‐E1 Cells , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[55]  B. Boyan,et al.  Titanium surface roughness alters responsiveness of MG63 osteoblast‐like cells to 1α,25‐(OH)2D3 , 1998 .

[56]  R A Brand,et al.  Toward an understanding of implant occlusion and strain adaptive bone modeling and remodeling. , 1999, The Journal of prosthetic dentistry.

[57]  J. Klein,et al.  Identification and characterization of amelogenin genes in monotremes, reptiles, and amphibians. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[58]  G. Karsenty,et al.  Two distinct osteoblast-specific cis-acting elements control expression of a mouse osteocalcin gene , 1995, Molecular and cellular biology.

[59]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[60]  Y. Akagawa,et al.  RGD Peptides Regulate the Specific Adhesion Scheme of Osteoblasts to Hydroxyapatite but not to Titanium , 1998, Journal of dental research.

[61]  L Sennerby,et al.  Histologic evaluation of the bone integration of TiO(2) blasted and turned titanium microimplants in humans. , 2001, Clinical oral implants research.

[62]  R. Reiter,et al.  Role for short-range interactions in the formation of cartilage and muscle masses in transfilter micromass cultures. , 1994, Developmental Biology.

[63]  K. Daniels,et al.  Modulation of chondrogenesis by the cytoskeleton and extracellular matrix. , 1991, Journal of cell science.

[64]  A. Boyde.  A 3-D Model of Enamel Development At the Scale of One Inch to the Micron , 1987, Advances in dental research.

[65]  Y. Takeuchi,et al.  Differentiation and Cell Surface Expression of Transforming Growth Factor- Receptors Are Regulated by Interaction with Matrix Collagen in Murine Osteoblastic Cells (*) , 1996, The Journal of Biological Chemistry.

[66]  E. Nishida,et al.  Differentiation and Transforming Growth Factor-β Receptor Down-regulation by Collagen-α2β1 Integrin Interaction Is Mediated by Focal Adhesion Kinase and Its Downstream Signals in Murine Osteoblastic Cells* , 1997, The Journal of Biological Chemistry.

[67]  J. Bernard,et al.  Modeling and characterization of the CEJ for optimization of esthetic implant design. , 2004, The International journal of periodontics & restorative dentistry.

[68]  L. Cooper,et al.  Formation of mineralizing osteoblast cultures on machined, titanium oxide grit-blasted, and plasma-sprayed titanium surfaces. , 1999, The International journal of oral & maxillofacial implants.

[69]  J. Wozney,et al.  Clinical evaluation of recombinant human bone morphogenetic protein-2. , 2002, Clinical orthopaedics and related research.

[70]  G. Karsenty,et al.  MAPK Pathways Activate and Phosphorylate the Osteoblast-specific Transcription Factor, Cbfa1* , 2000, The Journal of Biological Chemistry.

[71]  C. Damsky,et al.  Interactions between integrin receptors and fibronectin are required for calvarial osteoblast differentiation in vitro. , 1997, Journal of cell science.

[72]  M. Bostrom,et al.  Potential Role of Bone Morphogenetic Proteins in Fracture Healing , 1998, Clinical orthopaedics and related research.

[73]  A. Veis,et al.  Amelogenin gene splice products: potential signaling molecules , 2003, Cellular and Molecular Life Sciences CMLS.

[74]  Y. Morimoto,et al.  Albumin microspheres as drug carriers. , 1985, Critical reviews in therapeutic drug carrier systems.

[75]  R. Barrack,et al.  The Use of the OP-1 Implant in Reconstructive Surgery of the Hip and Knee , 2004 .

[76]  R. Woody,et al.  Implant materials, design, and surface topographies: their influence on osseointegration of dental implants. , 2003, Journal of long-term effects of medical implants.

[77]  D. Carnes,et al.  Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. , 2000, Journal of periodontology.

[78]  F. Cui,et al.  Preparation of calcium phosphate coatings on titanium implant materials by simple chemistry. , 1998, Journal of biomedical materials research.

[79]  G. Rodan,et al.  Bisphosphonate mechanism of action , 2002, Current molecular medicine.

[80]  C. Stanford,et al.  Osteoblast Integrin Adhesion and Signaling Regulate Mineralization , 2001, Journal of dental research.

[81]  J. Moradian-Oldak,et al.  Detection of monodisperse aggregates of a recombinant amelogenin by dynamic light scattering , 1994, Biopolymers.

[82]  G. Karsenty,et al.  A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development. , 1999, Genes & development.

[83]  J. Deng,et al.  The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation , 2002, Cell.

[84]  L. Cooper,et al.  Evaluation of a predictive model for implant surface topography effects on early osseointegration in the rat tibia model. , 2001, The Journal of prosthetic dentistry.

[85]  P. Layrolle,et al.  Incorporation of tobramycin into biomimetic hydroxyapatite coating on titanium. , 2002, Biomaterials.

[86]  C. Douglass,et al.  Will there be a need for complete dentures in the United States in 2020? , 2002, The Journal of prosthetic dentistry.

[87]  D H Kohn,et al.  Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro. , 2000, Journal of biomedical materials research.

[88]  J. Moradian-Oldak,et al.  The structural biology of the developing dental enamel matrix. , 1999, Journal of structural biology.

[89]  S. Stupp,et al.  Self-assembling and biomimetic biomaterials , 2003 .

[90]  L. Cooper,et al.  Spatiotemporal Assessment of Fetal Bovine Osteoblast Culture Differentiation Indicates a Role for BSP in Promoting Differentiation , 1998, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[91]  H F Hildebrand,et al.  Cell orientation and cytoskeleton organisation on ground titanium surfaces. , 2002, Biomolecular engineering.

[92]  J. Wozney,et al.  The bone morphogenetic protein family and osteogenesis , 1992, Molecular reproduction and development.

[93]  J. Aubin,et al.  The mature osteoblast phenotype is characterized by extensive plasticity. , 1997, Experimental cell research.

[94]  Jin Jiang,et al.  Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. , 2004, Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics.

[95]  L. Cooper,et al.  Restricted and coordinated expression of beta3-integrin and bone sialoprotein during cultured osteoblast differentiation. , 1999, Bone.

[96]  I. Nishimura,et al.  Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. , 2003, The International journal of oral & maxillofacial implants.

[97]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[98]  R. Brand,et al.  Cellular deformation reversibly depresses RT-PCR detectable levels of bone-related mRNA. , 1995, Journal of biomechanics.

[99]  V A Marker,et al.  Implant materials, designs, and surface topographies: their effect on osseointegration. A literature review. , 2000, The International journal of oral & maxillofacial implants.

[100]  F. Reinholt,et al.  Distribution of integrin subunits on rat metaphyseal osteoclasts and osteoblasts. , 1993, European journal of cell biology.

[101]  P. Branemark.  Osseointegration and its experimental background. , 1983, The Journal of prosthetic dentistry.

[102]  C. V. van Blitterswijk,et al.  Incorporation of bovine serum albumin in calcium phosphate coating on titanium. , 1999, Journal of biomedical materials research.

[103]  R. Franceschi,et al.  Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3‐E1 cells , 1992, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[104]  J Lindström,et al.  Intra-osseous anchorage of dental prostheses. I. Experimental studies. , 1969, Scandinavian journal of plastic and reconstructive surgery.

[105]  J. Moradian-Oldak,et al.  Interaction of amelogenin with hydroxyapatite crystals: an adherence effect through amelogenin molecular self-association. , 1998, Biopolymers.

[106]  S. Radin,et al.  Calcium phosphate ceramic coatings as carriers of vancomycin. , 1997, Biomaterials.

[107]  R Z LeGeros,et al.  Three‐Dimensional Finite Element Analyses of Four Designs of a High‐Strength Silicon Nitride Implant , 2000, Implant dentistry.

[108]  B. Boyan,et al.  Surface roughness modulates the response of MG63 osteoblast-like cells to 1,25-(OH)(2)D(3) through regulation of phospholipase A(2) activity and activation of protein kinase A. , 1999, Journal of biomedical materials research.

[109]  I. G. Turner,et al.  Vacuum plasma sprayed hydroxyapatite coatings on titanium alloy substrates: Surface characterization and observation of dissolution processes using atomic force microscopy , 1996 .

[110]  C. V. van Blitterswijk,et al.  Biomimetic coprecipitation of calcium phosphate and bovine serum albumin on titanium alloy. , 2001, Journal of biomedical materials research.

[111]  T. Diekwisch,et al.  Evidence for amelogenin "nanospheres" as functional components of secretory-stage enamel matrix. , 1995, Journal of structural biology.

[112]  C M Stanford,et al.  Rapidly Forming Apatitic Mineral in an Osteoblastic Cell Line (UMR 10601 BSP) (*) , 1995, The Journal of Biological Chemistry.

[113]  J C Keller,et al.  Optimization of surface micromorphology for enhanced osteoblast responses in vitro. , 1993, The International journal of oral & maxillofacial implants.

[114]  R. Caffesse,et al.  Enamel matrix derivative and bone healing after guided bone regeneration in dehiscence-type defects around implants. A histomorphometric study in dogs. , 2002, Journal of periodontology.

[115]  C. Douglass,et al.  Future needs for fixed and removable partial dentures in the United States. , 2002, The Journal of prosthetic dentistry.

[116]  G N King,et al.  Bone morphogenetic protein-2 stimulates cell recruitment and cementogenesis during early wound healing. , 2001, Journal of clinical periodontology.

[117]  J. Jansen,et al.  Effect of microgrooved poly-l-lactic (PLA) surfaces on proliferation, cytoskeletal organization, and mineralized matrix formation of rat bone marrow cells. , 2000, Clinical oral implants research.

[118]  S A Gansky,et al.  Mechanical properties of the dentinoenamel junction: AFM studies of nanohardness, elastic modulus, and fracture. , 2001, Journal of biomedical materials research.

[119]  J. Moradian-Oldak,et al.  Interactions of Amelogenins with Octacalcium Phosphate Crystal Faces Are Dose Dependent , 2004, Calcified Tissue International.

[120]  J. Davies,et al.  Mechanisms of endosseous integration. , 1998, The International journal of prosthodontics.

[121]  D. Schlaepfer,et al.  Signaling through focal adhesion kinase. , 1999, Progress in biophysics and molecular biology.

[122]  T. Albrektsson,et al.  Design and surface characteristics of 13 commercially available oral implant systems. , 1993, The International journal of oral & maxillofacial implants.

[123]  A. George,et al.  Characterization of a mouse amelogenin [A-4]/M59 cell surface receptor. , 2006, Bone.

[124]  P. Ducheyne,et al.  Bone tissue growth enhancement by calcium phosphate coatings on porous titanium alloys: the effect of shielding metal dissolution product. , 1992, Biomaterials.

[125]  S. Ludwig,et al.  Osteoinductive bone graft substitutes , 2000, European Spine Journal.

[126]  U Kragh-Hansen,et al.  Structure and ligand binding properties of human serum albumin. , 1990, Danish medical bulletin.

[127]  J. Wozney,et al.  Biological mediators for periodontal regeneration. , 1999, Periodontology 2000.

[128]  R. Tuan,et al.  Regulation of human osteoblast integrin expression by orthopedic implant materials. , 1996, Bone.

[129]  J. Jansen,et al.  Ectopic bone formation in titanium mesh loaded with bone morphogenetic protein and coated with calcium phosphate. , 2001, Plastic and reconstructive surgery.

[130]  L. Cooper.  Cellular interactions at commercially pure titanium implants , 2003 .

[131]  Y Oda,et al.  Bone response to calcium phosphate-coated and bisphosphonate-immobilized titanium implants. , 2002, Biomaterials.

[132]  T. Diekwisch,et al.  Self-assembly of a recombinant amelogenin protein generates supramolecular structures. , 1994, Journal of structural biology.

[133]  T. Hunter,et al.  Integrin signalling and tyrosine phosphorylation: just the FAKs? , 1998, Trends in cell biology.

[134]  K. Debari,et al.  Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur , 2001, The Anatomical record.

[135]  S. Weiner,et al.  On the relationship between the microstructure of bone and its mechanical stiffness. , 1992, Journal of biomechanics.

[136]  K. Daniels,et al.  Micromass cultures of limb and other mesenchyme. , 1996, Methods in cell biology.

[137]  S. Dedhar,et al.  Integrin expression in human bone , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[138]  D. Cochran,et al.  Radiographic analysis of regenerated bone around endosseous implants in the canine using recombinant human bone morphogenetic protein-2. , 1997, The International journal of oral & maxillofacial implants.

[139]  C. Sukotjo,et al.  Molecular Cloning of Wound Inducible Transcript (wit 3.0) Differentially Expressed in Edentulous Oral Mucosa Undergoing Tooth Extraction Wound-healing , 2002, Journal of dental research.

[140]  D. Carnes,et al.  Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. , 2000, Journal of periodontology.

[141]  Renny T. Franceschi,et al.  Role of the α2-Integrin in Osteoblast-specific Gene Expression and Activation of the Osf2 Transcription Factor* , 1998, The Journal of Biological Chemistry.