Four cases of Graves' disease which developed after painful Hashimoto's thyroiditis.

We report four cases of Graves' disease that developed after painful Hashimoto's thyroiditis. All were middle-aged women, who had high titers of anti-thyroid antibodies and thyrotoxicosis at the onset of painful Hashimoto's thyroiditis. After 2 to 7 years, they developed Graves' disease with positive antibody against the thyrotropin receptor. Their clinical courses of Graves' disease went favorably due to the treatment with antithyroid drug or radioactive iodine therapy. Painful Hashimoto's thyroiditis is an atypical variant of Hashimoto's thyroiditis and is one form of destructive thyroiditis. Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease.

[1]  A. Miyauchi,et al.  Successful treatment for recurrent painful Hashimoto's thyroiditis by total thyroidectomy. , 2005, Thyroid : official journal of the American Thyroid Association.

[2]  L. Degroot,et al.  Painful Hashimoto's thyroiditis as an indication for thyroidectomy: clinical characteristics and outcome in seven patients. , 2003, The Journal of clinical endocrinology and metabolism.

[3]  D. Papanicolaou,et al.  Successful outcome after surgical management in two cases of the "painful variant" of Hashimoto's thyroiditis. , 2002, Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.

[4]  M. Iitaka,et al.  Induction of autoimmune hypothyroidism and subsequent hyperthyroidism by TSH receptor antibodies following subacute thyroiditis: a case report. , 2001, Endocrine journal.

[5]  J. Lazarus,et al.  Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. , 2000, The Journal of clinical endocrinology and metabolism.

[6]  K. Badenhoop,et al.  Graves' hyperthyroidism after postpartum thyroiditis. , 1998, Thyroid : official journal of the American Thyroid Association.

[7]  D. Jaeck,et al.  Relapse of Graves' disease after subacute thyroiditis. , 1998, Thyroid : official journal of the American Thyroid Association.

[8]  N. Ishikawa,et al.  TSH receptor antibody‐associated thyroid dysfunction following subacute thyroiditis , 1998, Clinical endocrinology.

[9]  H. Nièpomniszcze,et al.  Development of Graves' disease nine years after total thyroidectomy due to follicular carcinoma of the thyroid. , 1997, Thyroid : official journal of the American Thyroid Association.

[10]  F. Brucker-Davis,et al.  Graves' disease following thyrotoxic painless thyroiditis. Analysis of antibody activities against the thyrotropin receptor in two cases. , 1997, Thyroid : official journal of the American Thyroid Association.

[11]  C. Shigemasa,et al.  Pertechnetate thyroid uptake is not always suppressed in patients with subacute thyroiditis. , 1997, Clinical nuclear medicine.

[12]  J. Amano,et al.  Development of Graves' disease from asymptomatic autoimmune thyroiditis: a case report. , 1996, Endocrine journal.

[13]  F. Bogazzi,et al.  Graves' disease occurring after subacute thyroiditis: report of a case and review of the literature. , 1996, Thyroid : official journal of the American Thyroid Association.

[14]  T. Takano,et al.  A case of repeated painless thyroiditis followed by Graves' disease. , 1995, Endocrine journal.

[15]  A. Pinchera,et al.  Appearance of thyroid stimulating antibody and Graves' disease after radioiodine therapy for toxic nodular goitre , 1994, Clinical endocrinology.

[16]  R. Volpe The management of subacute (DeQuervain's) thyroiditis. , 1993, Thyroid : official journal of the American Thyroid Association.

[17]  P. Walfish,et al.  Postparathyroidectomy transient thyrotoxicosis. , 1992, The Journal of clinical endocrinology and metabolism.

[18]  F. Matsuzuka,et al.  Development of Graves' disease after subacute thyroiditis: two unusual cases. , 1992, Acta endocrinologica.

[19]  T. Hara,et al.  The role of thyroid stimulating antibody (TSAb) in the thyroid function of patients with post‐partum hypothyroidism , 1992, Clinical endocrinology.

[20]  S. Taniguchi,et al.  Chronic thyroiditis with painful tender thyroid enlargement and transient thyrotoxicosis. , 1990, The Journal of clinical endocrinology and metabolism.

[21]  P. Smyth,et al.  Sequential presentation of a case of hyperthyroidism with autonomously functioning nodules and Graves' disease in the presence of IgG thyroid stimulators. , 1988, Acta endocrinologica.

[22]  Y. Iwatani,et al.  Long term follow-up and HLA association in patients with postpartum hypothyroidism. , 1988, The Journal of clinical endocrinology and metabolism.

[23]  R. Jansson,et al.  Postpartum thyroiditis. , 1988, Bailliere's clinical endocrinology and metabolism.

[24]  H. Imura,et al.  Histological, clinical and laboratory findings of acute exacerbation of Hashimoto's thyroiditis--comparison with those of subacute granulomatous thyroiditis. , 1987, Endocrinologia japonica.

[25]  L. Wartofsky,et al.  Graves' disease with thyrotoxicosis following subacute thyroiditis. , 1987, The American journal of medicine.

[26]  R. Smallridge,et al.  Persistent thyroid autoimmunity after subacute thyroiditis. , 1987, Journal of clinical & laboratory immunology.

[27]  R. Roberts,et al.  Postpartum lymphocytic thyroiditis. Prevalence, clinical course, and long-term follow-up. , 1987, Archives of internal medicine.

[28]  H. Imura,et al.  Pathological characteristics of acute exacerbation of Hashimoto's thyroiditis--serial changes in a patient with repeated episodes. , 1986, Endocrinologia japonica.

[29]  A. Pontecorvi,et al.  Transitory subclinical and permanent hypothyroidism in the course of subacute thyroiditis (de Quervain). , 1984, Acta endocrinologica.

[30]  S. Werner Graves' disease following acute (subacute) thyroiditis. , 1979, Archives of internal medicine.

[31]  R. G. Wieland,et al.  Unusual events preceding hyperthyroidism with diffuse goiter. , 1977, Archives of internal medicine.

[32]  Willard A. Burns,et al.  Report of a Case and Review of the Literature , 2017 .

[33]  R. Wasnich,et al.  Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease. , 1973, The Journal of clinical endocrinology and metabolism.

[34]  W. Perloff Thyrotoxicosis following acute thyroiditis; a report of 5 cases. , 1956, The Journal of clinical endocrinology and metabolism.

[35]  Sheets Rf The sequential occurrence of acute thyroiditis and thyrotoxicosis. , 1955 .

[36]  R. Sheets The sequential occurrence of acute thyroiditis and thyrotoxicosis. , 1955, Journal of the American Medical Association.